Antihypertensives Antihypertensive/ -pril suffix Antihypertensive/ -tan suffix Action: inhibits activity of the SNS, Route: PO Action: instead of decreasing production of causing decreased BP Action: by blocking production of angiotensin II, they block the vasoconstricting Alpha1-adrenergic receptor blockers: angiotensin II, decreases & aldosterone-secreting effects of angiotensin Prazosin (Minipress) dilate blood vasoconstriction & decreases II at various receptor sites vessels and decrease peripheral aldosterone production (reduces Do not cause cough & hyperkalemia resistance retention of sodium & water). Also, Adverse effects: dizziness, muscle cramps, Alpha 2 agonists: Clonidine inhibits the breakdown of bradykinin weakness, heartburn, diarrhea, angioedema (Catapres) cause the release of less (prolongs vasodilation) NI: assess BP, lifestyle modifications norepinephrine and a reduction of Adverse effects: persistent cough, Patient Edu: take without regards to meals sympathetic outflow from the hypertension, hyperkalemia, This drug is a teratogenic, so do not use vasomotor center. Decreased CO, HR, neutropenia, proteinuria, during pregnancy peripheral vascular resistance and BP glomerulonephritis, angioedema Beta-Adrenergic Blockers: NI: administer 1 hr before or 2 hrs Metoprolol (Lopressor) decrease HR, after meal because absorption force of myocardial contraction, CO, reduced by food; assess BP & pulse, and renin release from the kidneys lifestyle modifications Hypertension NI: Monitior HR, BP, orthostatic This drug is a teratogenic, so do not hypotension Drug Therapy use during pregnancy
Calcium Channel Blockers: Amlodipine
(Norvasc) Antihypertensive/ may be prescribed with Diuretics: a thiazide diuretic or used alone Mild to moderate HTN/ 1st line Direct Vasodilators: Nitroprusside (Nitopress) Action: inhibits the influx of calcium ions therapy Used for HTN & heart failure across cardiac and smooth muscle during Initially decreases blood volume Route: IV depolarization, resulting in relaxation & & CO but continues to decrease Directly relaxes the smooth muscle in vasodilation peripheral vascular resistance blood vessels, resulting in dilation and Adverse effects: h/a, drowsiness, fatigue, May need to be combine with decreased peripheral vascular resistance dizziness, edema of hands, ankles, and another antihypertensive NI: continuous BP monitoring feet, flushing, palpitations, nausea 3 main types: abdominal pain Thiazide (Hydrochlorothiazide) NI: Assess BP and lifestyle modifications, Loop (Furosemide) given without regard to food Potassium sparing Patient Edu: avoid grapefruit juice & St. (Spironolactone) John’s Wort