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Angiotensin-converting enzyme (ACE) Angiotensin II receptor blockers (ARBs): Antiadrenergics:

inhibitors: Lisinopril (Prinivil) / Captopril Losartan (Cozaar)


 Antihypertensives
 Antihypertensive/ -pril suffix  Antihypertensive/ -tan suffix
 Action: inhibits activity of the SNS,
 Route: PO  Action: instead of decreasing production of causing decreased BP
 Action: by blocking production of angiotensin II, they block the vasoconstricting
 Alpha1-adrenergic receptor blockers:
angiotensin II, decreases & aldosterone-secreting effects of angiotensin
Prazosin (Minipress) dilate blood
vasoconstriction & decreases II at various receptor sites
vessels and decrease peripheral
aldosterone production (reduces  Do not cause cough & hyperkalemia resistance
retention of sodium & water). Also,  Adverse effects: dizziness, muscle cramps,  Alpha 2 agonists: Clonidine
inhibits the breakdown of bradykinin weakness, heartburn, diarrhea, angioedema (Catapres) cause the release of less
(prolongs vasodilation)  NI: assess BP, lifestyle modifications norepinephrine and a reduction of
 Adverse effects: persistent cough,  Patient Edu: take without regards to meals sympathetic outflow from the
hypertension, hyperkalemia,  This drug is a teratogenic, so do not use vasomotor center. Decreased CO, HR,
neutropenia, proteinuria, during pregnancy peripheral vascular resistance and BP
glomerulonephritis, angioedema  Beta-Adrenergic Blockers:
 NI: administer 1 hr before or 2 hrs Metoprolol (Lopressor) decrease HR,
after meal because absorption force of myocardial contraction, CO,
reduced by food; assess BP & pulse, and renin release from the kidneys
lifestyle modifications Hypertension  NI: Monitior HR, BP, orthostatic
 This drug is a teratogenic, so do not hypotension
Drug Therapy
use during pregnancy

Calcium Channel Blockers: Amlodipine


(Norvasc)
 Antihypertensive/ may be prescribed with Diuretics:
a thiazide diuretic or used alone  Mild to moderate HTN/ 1st line Direct Vasodilators: Nitroprusside (Nitopress)
 Action: inhibits the influx of calcium ions therapy  Used for HTN & heart failure
across cardiac and smooth muscle during  Initially decreases blood volume  Route: IV
depolarization, resulting in relaxation & & CO but continues to decrease  Directly relaxes the smooth muscle in
vasodilation peripheral vascular resistance blood vessels, resulting in dilation and
 Adverse effects: h/a, drowsiness, fatigue,  May need to be combine with decreased peripheral vascular resistance
dizziness, edema of hands, ankles, and another antihypertensive  NI: continuous BP monitoring
feet, flushing, palpitations, nausea  3 main types:
abdominal pain  Thiazide (Hydrochlorothiazide)
 NI: Assess BP and lifestyle modifications,  Loop (Furosemide)
given without regard to food  Potassium sparing
 Patient Edu: avoid grapefruit juice & St. (Spironolactone)
John’s Wort

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