7 Hy PERSENS (TLV (TY 3 a A hat htenecl iannreine serponre of aD imafproprate 7 exacacratéal trmene Actponte _'8 3 zi alld Ty ponnensitevl oy crlleray gy ° [injurious to bedy “Peatics 4 Rechel ~ Telly ifs toxins injected inte dogsprophglacis ~ “They teamed if at -anaphaslacée l Pek protective f Essenlialt fv Hapessensituity ' ee eg ~=Conlact with Antigen (Ingest, touch e&) a sven’ve — papergriq = Seasitixing / PatMirng Dood Chast tere dose) = Induckon “ana /aktr = Stacking Bose (body nat pooleted sally second teva. 4 Oveitacting d Hipetsensitive Reackions /Allecate Reaction“Iype 4 — involves Iq & Ab ee 2 = Iq gm =e mediated Cel foto x te haporsonsctvt ty Type 8 — 394 Tmmure comple " pnedialed g Giype t= Delayed hy pouensitinity — TPM cell mediated ! 1 delayed Helper cells T 7g Tig colle ~ Sesponse delay the 4 precluce Te cells —T Fmmediate - reaction tales place within 24 hes Delayed on ny _mere_than ahs [Pifjasne bekown Tamediale # Delayed Pypeensitivity.] af Tomediote Hepeasens die Delayed Aypesenatt uty Aggeass ane) secedos Aapidly | _Appeass slowly, last j __| longes [WD || Fndurced by antigens ‘Antigens oy _haptent haplent bey an, Shake fnlaeclesma lly by colt, Execinds ody vants oF bey Skin comiaet* v(Wt) | Cracalating Ab pactent and | cereale suspen aeackon Cell me diate: rr heat 1 (iv) || Passive Leaner possible Cannot be rant ova sith gexum by serum, but ¢ (v9 | Desensitization cay bul Diffieett bul_long Shovt lived lasting Tipe. 1 Hypeasensitive Rea Reactions Vie Fo a (Bichonvaal _ [Mast Celt Degrancslation Ctesop fale] Tape L hs pessensi tivity involves mest celle # Bout phils Celt-membevt fas’ mask celts with Basopbils When a poston is fivst sensitized sbith the Ay Beells pleduod Bie ah against Hs hy a there Ab sou “perend on be mant cel basophils Ab paesent next to each other te allecqen will tome 2 bind to these boo Mbpaeent m K. call f 4papergrid Date: 1 J ceptors parsent extra f to the Fe xegion fl th Ab(Ig E) tors “are protein molecules —~ When allecgen ig not they que’ in the Inactive fon L when allergen has bound to Ab (ea0sslinleing ) they become a oo Once thee 8 crosslinking fev the fast tome — phesphe Tyrosine kinase” (PT) enxynu. gels f 4 activated phosphnry lates -sphospho hipmae © (enzane) T T U T T / T boca ke down phoep ho bily phosphetidylimesitol be Nun reese bo Deas yerol Trutitol to photphate f her [Ps 1, funclion —y endopasmate velierdlam t the cell has _lasge amés J Calcium Calcicem is £9 wired - 1 Ypuit to come oud the cell 1 és fag ined: -i Papergrig DAG——> achvates_mactive phosphe kenase | ke tmto _ atkve PKC ——_ | Se Pe along with Calecum help in_don | 4G mimotebules. 2 Mere}ilamente Giilachid fe the mem buane 7 1 halp Inthe attachment Granules prssent! tm the cell 4 the basophils £ most cells have imacive I Aranciles past ont v Ts H ‘hay ex 10 become aclive 2 stleared ext Se the allergic seaction to take | fn sateating suk Q-hase Laneer then have be [Pat bound te e mum bone — thse Warcleng te clemt by the netore tet besles - d PSR - Phos hofice I sertrne | ‘ L Pee re eb To tohun there is cyess lin lacypapergrid Date: / / Pe gets methylated by too enxtymer PMT rami Fr o a TF me - J ges caved F 7 O adh S| phe i‘. deptekotrre Moreases dna in the membrane and the membrane sevells ——> influx g Calera Yt ) rr because J a _boealk tthe mmumbyane. | lever dutte the milax, enzyme phospho Lipa. Apwconvest Be. into lygo PCat Avachionie accel L messengers of pacsen? in ell beconung active Arachidonue acco! mussengess bride the LO — YJ qraneeles Leukotriene Presfaglandin Da Ae These ean activate the granules 2 they suo Ua 2 pel altached to the rierota bales - (But “rere pre shill mol brecken to come oct « the eal) » |(PaRt Sy the qoanuler arquucte enero, to move on ey bredk open the cell membrane — ] Allowing ium lo svell 8 tl busat 2 all contents are seleced ouk ——_ a ——_| to which tx body seeks + nla ac [Atergent coo be dil kya] — Pleo: = pollen gins inch tae ole Danas Tectia bees eed = Bay wl [Patines 2 Sceondany Mectiators ‘] ten the _qranceler d the Qrerules ase prvent Yak oe emactive Mast cell 2 beste hile _| Mediotos _& gets a "Tm mreased vascrslas_pesmrabili Srmoold munde contoaction || Histamine , | a ” Fades eA) ~ Eosinezhil cherme fair, Neoopla - chump laxis ~ 2 Newtoophil chemodaeis: Bronchial mucous secretin deqradatio 6] blecol vessel “pewemend ‘membrane Proteases = Secondany affects 4, Type I bespessersitvi Platelet ackuating Factr — platelet agqzeqation @ eq ranvelafter contrerackon i pulmonary gmeoth rein cles || Beeckotecenct = Tmoveated vatcaales paca pild | tandaacton 4 galmaty tnoet muda.’ | Prostaaareins = Vasedilation eonluockon, plated TET Aggaeqalton ‘ fous- |h- ae we i Se t r INE - of Alec cna floss,@ Skin Test: Bedi Scratch, porck test - woith Aq The Antigen coated onto a nudle ow 2 Scratched or prteked eno the ekin ¢ any Kimel of seackion te observed i ty thos Ie acaction ( swelling, acdnes ete) tve # Hf me asaction —ve RAST — Raceo Allerg ar Sov bent Test ! Absorb an allagen onto a rulix —alluasinbok 2 delecting YH ustng sadicactvity U L Pale pan] chance fox _matation 40 oceces nceeeR So So evel _ mot doe pee | Ig€ Ab can be detected ion the patient. : = Ab isolated cleaved & tmpectecl into an —_.—— crumal.— Anti Ab ts prectucedl against he i a aa Racliolabelledl the Fe on tke A Ab fei fait ob | are babespapergrid Date: / | | Treabate seum + allergen bourd to amater Ig € Abts serum wold bend to tho allege f wn it_allugie to iE * | ps 3 Alte Imathation ——p coash ff what birds Aematnt | pp wadtolabeltlfortsectul t 1 iit bend to Fe potion gh boural te alleen L Aadtolabelled 2° Ab coil show pin a Counter. spetifoc te the arodioactive’ material te : s Tar Dovegs for dpe _T Hy pesaensi: vil Antihistamines — Block Ul @H2 Aeceptess om 7 t forget alls thosebs prevertery histamine binding to! Ace pters [Disoduum wnomeglysale — Blocks caleruen imlax ints ( cremelym Sodium) smoast cells: : | thee phy tere = ik pers SI ‘in _mnart collls — blocks deqrare dongs high cAMP levels jection « Epemaphaine( Achemabiou)— _contenuons PN" fy \ || Atergce shenits Somer papergrg Atepe Tre 1 HYreRsensmivitd ? *tg@ mediated thes compleres cautet Ab fo be produerd egaunst it 2 Ab will attack te complex bound 4 —— R808 tye ib TYPE T HYPER SENSeriVITY ! PS | Tmnmune conpler mediated hy pestensitrui When z senall they can be moved, hal 4 Ag = Ab cong dapastial in vanlous sss tne Cong iceman activation * OR P Fall [lama avepmse ~inftleoleo macrophages & Asthus grachion (Suum sickness) Me { patton Aecbiver & baum from a hae ele on might have get allergic 2 tT _ ee Ee t= a a | Gilerserule oxphattes =_dupostted im glommulat gion Rheumatord avinattes ~self antigens axe Aucgmized._| v momaphages eink gels’ tracTee WV pupersensirivitd: No Ab imvolved — eft sefored 40 as as cell mechioted hapessensitive aoaction ppusifued £4: contact dumatites = conbel wit Bue PPD ~ ‘Tubercerlem tert fata ‘den wae 1 pevler V dexivecd Gaoft sefection. — secon by acc Sensitined TH, alls Acleare cote eines — activates Macnephages oe Te cells — mediate clirect cetelar Sensictt sation phase 4 Electr phase {_— eae v bacteria. i intracellular parcrcter i