CHE 313 CASE STUDY ASSIGNMENT (Spring 2012)

Due: Friday May 25 2012 at 10:00 AM

Transport Phenomena Modeling (Optional)

This is a case study that you must select based on any topics related to the applications of
Transport Phenomena. A list of acceptable topic is available so you can pick a topic from the list,
the first person signing the name next to the topic will be responsible for it. You can also choose
your own topic with approval from the instructor. You must read at least 2 references beside the
reference given to you and turn in a copy of these two references in electronic form if possible.
Your case study must be quantitative. There must be an equation or set of equations presented to
describe the transport phenomena. The solutions to the equation(s) must also be presented and
discussed.

Grading criteria:
Presentation of relevant information (20%)
- You must present your case study with a typed-written title page and an executive
summary. The format for the title page is given in the opposite page. You need to assign a title to
your case study.
- You must write an introduction (backgrounds materials) for the topic before you
describe the transport model, its significances and applications. You must provide all the
necessary information toward the solution of the model. You should include picture(s) to
illustrate the description.

Model development (25%)

- Make a sketch of the system
- List all the assumptions, physical properties, and parameters.
- Derive the equations for your system in details.

Solution (25%)
- Solve the transport model analytically or by using any software package (You can use
COMSOL MULTIPHYSICS, MATLAB, EXCEL...).
- Verify and present the results in graphical form. You should plot the dependent
variable(s) versus the independent variable(s) with a realistic set of parameters. You are to plot
the effect of perturbations (+/- 50%) of these parameters on the dependent variable(s).

Discussion of results (20%)

- Discuss the assumptions and the solutions and possible applications of the solution.

General completeness and neatness (10%)

- Your report should contain: (A sample report is available in the distribution folder in the
CHE 313 course)
1. Title page.
2. Executive summary: This should succinctly summarize your problem, your results,
and your conclusions. This summary should not exceed two typed written pages.
3. Transport Model: This should contain an introduction and detailed description of
the model.
 4. Model Solution: This should contain solution, and results in graphical form.
5. Discussion. This should contain your analysis of the results and the application.
6. Appendices: This should contain any relevant materials (EX: Derivation of
equation(s), your computer program, computer output, copies of reference literatures,...)

Put your report and references in a folder created with your last name. Copy
this folder into the Homework & Exam folder of CHE 313 by May 27 2011 at
11 AM.

Lists of acceptable topics: Name

(1)1 Numerical solution for the oxygen concentrations

within the blood and tissue regions ________________________

(2) 1 Diffusion of urea in both stagnant and flowing

blood (Colton and Lowrie 1981) _____Vo Quynh___________

(3) 1 The sieving coefficient for the case of concentration

polarization (Mochizuki and Zydney 1992) _____Alex___________

(4) 1 Hindered transport of large molecules in

liquid-filled pores (Deen 1987) ________________________

(5) 1 Modeling of oxygen uptake in perfluorocarbon

emulsions (Shah 1996) ________________________

(6) 1 Reaction and Diffusion in Immobilized Enzyme ________________________

Systems.

(7) 1 A Two-Compartment Model for an Intravenous

Injection ________________________

(8) 1 A Two-Compartment Model for First Order

Absorption ________________________

(9) 1 Analysis of a Membrane Oxygenator, Oxygen

Transfer ________________________

(10) 1 Analysis of a Membrane Oxygenator, Carbon

Dioxide Transfer ________________________

(11) 1 Reactor Design Equation: Packed-Bed Reactor,

Well-Mixed Reactor ________________________

(12) 1 Pharmacokinetic Modeling of Inulin Transport

in a Polymeric Support Structure _____Linh___________________
(13) 1 Islet Insulin Release Model ________________________

(14) 1 Pharmacokinetic Modeling of Glucose and

Insulin Interactions ____ ThanhBinh __________

(15) 1 Using the Pharmacokinetic Model to Evaluate

the Performance of a Bioartificial Pancreas _____Shaun_________

(16)* Oscillating Flow in a Cylindrical Tube ________________________

(17)* Model of Diffusion of a Solute into a Sphere ____Scott______________

(18)* Transport Effects Upon Enzymatic Reactions ________________________

(19)* Receptor-Ligand Binding Kinetics ________________________

(20)* A Kinetic Model for LDL Receptor-Mediated

Endocytosis ________________________

(21)* Receptor Regulation during Receptor-Mediated

Endocytosis ________________________

(22)* Simplified Model for Gene Induction and Expression ________________________

(23)* Biophysics of Leukocyte Rolling and Adhesion ________________________

(24)* Stochastic Effects on Chemical Interactions ________________________

(25)* Dynamics of Oxygenation of Blood in Lung Capillaries ________________________

(26)* Nitric Oxide Production and Transport in Tissues ________________________

(27)* Unidirectional Transport in a Solid Tumor ________________________

(28)* Pharmacokinetic Analysis of Methotrexate ________________________

(29)* Allometric Scaling Law in Pharmacokinetic Analysis ________________________

1
Basic Transport Phenomena in Biomedical Engineering by Fournier, Taylor & Francis,
2007
*
Transport Phenomena in Biological Systems by Truskey, Yuan, and Katz, Prentice Hall,
2004
 California State Polytechnic University, Pomona

Chemical&Materials Engineering Department

CHE 313: Mass Tranfer

CASE STUDY

The Performance of a Bioartificial Pancreas

Date: May 27 2011

by

Last name, first

This case study is given under the Honor System and by typing my name here

____________________________________________
I have agreed that the work submitted is my work alone and that I neither sought nor
received help from others.

Presentation 20% ________

Model development 25% ________
Solution 25% ________
Discussion 20% ________
Completeness and Neatness 10% ________