6/4/2021 Drugs that cause or prolong delirium - UpToDate

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Drugs believed to cause or prolong delirium or confusional states*

Analgesics Corticosteroids
NSAIDs Dopamine agonists
Opioids (especially meperidine)
Amantadine

Antibiotics and antivirals Bromocriptine

Acyclovir Levodopa

Aminoglycosides Pergolide

Amphotericin B Pramipexole

Antimalarials Ropinirole

Cephalosporins Gastrointestinal agents

Cycloserine
Antiemetics
Fluoroquinolones
Antispasmodics
Isoniazid Histamine-2 receptor blockers
Interferon Loperamide
Linezolid
Herbal preparations
Macrolides
Atropa belladonna extract
Metronidazole
Henbane
Nalidixic acid
Mandrake
Penicillins
Jimson weed
Rifampin
St. John's wort
Sulfonamides
Valerian
Anticholinergics
Hypoglycemics
Atropine
Hypnotics and sedatives
Benztropine
Barbiturates
Diphenhydramine
Benzodiazepines
Scopolamine

Trihexyphenidyl Muscle relaxants

Baclofen
Anticonvulsants
Cyclobenzaprine
Carbamazepine

Levetiracetam Other CNS-active agents

Phenytoin Disulfiram

Valproate Cholinesterase inhibitors (eg, donepezil)

Vigabatrin Interleukin-2

Antidepressants Lithium

Phenothiazines
Mirtazapine

Selective serotonin reuptake inhibitors

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6/4/2021 Drugs that cause or prolong delirium - UpToDate
Tricyclic antidepressants

Cardiovascular and hypertension drugs

Antiarrhythmics

Beta blockers

Clonidine

Digoxin

Diuretics

Methyldopa

NSAIDs: nonsteroidal antiinflammatory drugs; CNS: central nervous system.

* Not exhaustive, all medications should be considered.

Graphic 70449 Version 7.0

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