Jikky Kjj @JikkyKjj

Jan 6, 2022 • 4 tweets • JikkyKjj/status/1478909362991091713

So... was it intended to go to the nucleus all along?

Lipid nanoparticles are not only "protecting the mRNA

from degradation" but are a transfectant facilitating nuclear
delivery.

@Clucky92864053 @fynn_fan @chrismartenson

@MaryanneDemasi
Which might explain this:

Jikky Kjj
@JikkyKjj

I'm only a mouse so I'm easily confused. When they

said "it doesn't get into the nucleus" did they mean
the RNA or the spike protein that the RNA
produces?

I wish I was clever like that nice Dr Fauci.

@Clucky92864053 @eh_den

4:35 AM · Dec 31, 2021

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And the coordinated attack on this paper. They really didn't want this published.

Now we know why.

https://www.mdpi.com/1999-4915/13/10/2056
Refs:

Nuclear localization of cationic solid lipid nanoparticles containing Pro…

Protamine has attracted much attention as DNA condenser and nuclear transfer
enhancer although the excess of hydrophilicity and the strong DNA pack restrain its
potentialities. In order to overcome t…

https://pubmed.ncbi.nlm.nih.gov/20691262/

N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouri…

Messenger RNA as a therapeutic modality is becoming increasingly popular in the
field of gene therapy. The realization that nucleobase modifications can greatly
enhance the properties of mRNA by redu…

https://pubmed.ncbi.nlm.nih.gov/26342664/

Transfection efficiency and transgene expression kinetics of mRNA de…

Transfection efficiencies and transgene expression kinetics of messenger RNA
(mRNA), an emerging class of nucleic acid-based therapeutics, have been poorly
characterized. In this study, we evaluated …

https://pubmed.ncbi.nlm.nih.gov/23306021/
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