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The Volume Bible was originally published in my Research Review where I keep
you up to date every month with the latest research on muscle gain and fat loss.
Click here to learn more. For some more free sample content before you buy, sign
up for my newsletter.
This article has now undergone its fourth major revision on 3/26/2020. Most
sections have been added to or rewritten. A few sections have been removed. Only
the early sections on protein synthesis/anabolic signaling and early meta-analyses
have remained the same.
TL;DR Version
Key Takeaways
Practical Application
• Introduction
• What do we mean by set?
• Impacts of set volume on:
◦ Muscle protein synthesis
◦ Anabolic signaling
◦ Satellite cells
• Beyond the biopsies: statistical power and studies on hypertrophy
• Meta-analyses on volume and hypertrophy
◦ 2010 meta-analysis (8 studies)
◦ 2016 meta-analysis (15 studies)
◦ Diving Deeper, Problems With Previous Meta-Analytic Approaches,
and the Inverted U Hypothesis
◦ Meta-regression and dose-response analyses
• Volume and strength
• How much is too much?
◦ Ostrowski study
◦ German volume training studies
◦ Baker study
◦ Haun study
• High volume dose response studies
◦ Radaelli study
◦ Schoenfeld study
◦ Heaselgrave study
◦ Ostrowski study
◦ Barbalho studies (removed from analysis as of February 2020)
◦ Aube study
◦ Brigatto study
◦ Reasons for differences among studies
• Finding Your Individual Volume Ceiling
• The Theoretical Case for Volume Cycling
• Volume Cycling Via Alterations in Frequency
• The Genetics of the Volume Response
• Counting Sets: The Direct Vs. Indirect Problem
• The practical limitations of very high volumes: a personal experiment
• Tying it all together
• Practical Application: A Moderate Volume Example
• Practical Application: A High Volume Specialization Example
• Wrapping it up
"How many sets should I do?" is probably one of the most common questions that
people have when trying to build muscle. In fact, the number of sets you should do
to build muscle can be such a point of contention that people have fought internet
and journal article wars over it. Entire training philosophies (i.e., High Intensity
Training and Heavy Duty) have been built around how many sets people think you
should do. In fact, for years, people have been arguing over whether you should
train with a low number of sets, or high number of sets, to maximize muscle
hypertrophy.
The best approach, of course, is to examine the scientific evidence, and consider
where the overall weight of the evidence lies. In regards to training volume, it's not
that easy, due to the limitations in the existing research. Still, that doesn't mean we
can't come up with some solid evidence-based recommendations.
The first thing we need to clarify is what we mean by a "set." In a weight training
workout, there are a lot of ways you can do a set, from a warm-up set that hardly
pushes you to failure, to a gut-busting set of 20-rep squats to failure. In this article, a
set is going to be defined as a set of moderate to high repetitions (approximately 8
reps or more) to muscular failure or near failure. I use this definition because high
load, low rep sets do not produce as much hypertrophy as more moderate 8-12 rep
sets, despite an equivalent number of hard sets. However, moderate-rep and high-
rep sets to failure are similar in their impacts on muscle hypertrophy. Also, a set
should be to near muscular failure, because stopping well short of failure will impair
muscle hypertrophy. Finally, a set counts towards a particular muscle group if that
muscle group can be considered a prime mover in the exercise that is being used.
For example, 3 sets of bench press will count as 3 sets for triceps, since the triceps
are active prime movers in a bench press. Three sets of bench press, and 3 sets of
tricep pushdowns, would count as 6 total sets.
One of the first places we can look for evidence is in the impact of set volume on
muscle protein synthesis. Remember that resistance training stimulates protein
synthesis, the process by which your muscles build new protein. When this process
of protein synthesis exceeds the rate of protein breakdown, your muscles grow. The
elevation in protein synthesis happens very quickly after a training session, and
continues for 24-48 hours after the session. If set volume impacts muscle
hypertrophy, then it would stand to reason that it may impact muscle protein
synthesis as well.
One study that examined the impact of set volume on muscle protein synthesis came
out of the lab of Stu Phillips. The researchers compared 3 sets of leg extensions to 1
set of leg extensions. Both groups trained at 70% 1-RM to muscular failure. Fed-
state muscle protein synthesis (the amount of protein your muscles make after you
eat a meal, which is really important when it comes to building muscle size) was
elevated by almost twice the amount in the 3-set group compared to the 1-set group.
Protein synthesis was still elevated by 130% at 29 hours after the training session in
the 3-set group, but was back to normal in the 1 set group. In other words, muscles
were not only making more protein soon after the workout with 3 sets to failure, but
they were still making more protein 29 hours later compared to 1 set. Since muscle
protein synthesis correlates with gains in muscle size once you get past the initial
muscle damage, this would imply that 3 sets is better than 1 set for putting on
muscle.
In another study looking at the impact of set number on muscle protein synthesis, 6
sets of 8 reps at 75% 1-RM on the leg extension caused greater muscle protein
synthesis up to 2 hours after the training session, as compared to 3 sets. This was
true in both young and old subjects. Also, in the older (but not the younger)
subjects, 6 sets of 14 reps at 40% 1-RM caused a greater muscle protein synthesis
response compared to 3 sets. There are two major problems with this study. First,
subjects did not train to failure...8 reps at 75% 1-RM, and 14 reps at 40% 1-RM, can
be far short of failure for some individuals on a leg extension. Second, the
researchers only measured protein synthesis out to 4 hours. Thus, this study might
suggest that 6 sets per muscle group is better than 3 for muscle protein synthesis, but
there are a lot of limitations to the study.
In a third study by Damas and colleagues, 12 sets to failure with 2 minute rests on
the quadriceps (6 sets of leg press and 6 sets of leg extensions) only caused a small
increase in muscle protein synthesis compared to 8 sets to failure (4 sets of each
exercise) in trained subjects.
From Damas et al. (2019). VAR-sets did 12 sets in quadriceps, while CON did 8 sets. The increase in muscle protein
synthesis from the additional 4 sets was very small, and was not related to hypertrophy.
This small increase in muscle protein synthesis was not associated with greater
hypertrophy over 8 weeks, suggesting that the small increase may have been more
due to a small increase in muscle damage. This data suggests that muscle protein
synthesis may begin to plateau somewhere in the 8-12 set range.
Finally, one rodent study found that muscle protein synthesis increased with an
increasing number of "sets" of electrically stimulated muscle contractions,
statistically plateauing at 5 sets but the raw mean peaked at 10 sets. Protein
synthesis tended to be lower at 20 sets. However, a "set" in this study may not be
equivalent to a a set as we define it. There are also other differences which I
described in a research review. Regardless of these differences, this data does align
nicely with the previous study by Damas et al., suggesting a plateau in muscle
protein synthesis somewhere around 10 sets.
Given these studies, we can say that multiple sets will create more protein
synthesis than single sets to failure, and it looks like the response may plateau
between 8-12 sets in a session on average.
Another place we can look is the impact of set volume on anabolic signaling. When
you train with weights, the tension on your muscles sends molecular signals to
muscle cells to start creating new protein. One important molecular signal is called
p70S6K phosphorylation, which has been found to correlate with gains in muscle
size when measured 5 hours after a training session.
There have been some studies that have examined the impact of set volume on
p70S6K phosphorylation. One study showed 10 sets of 10 RM (leg press, 2 min
rest) resulted in greater p70S6K phosphorylation compared to 5 sets of 10 RM when
measured 30 minutes after the session. In the protein synthesis study out of Stu
Phillips's lab that was mentioned earlier, p70S6K phosphorylation was significantly
elevated at 29 hours after 3 sets of leg extensions, but not 1 set. In a third study, 3
sets of 6 RM of a leg press resulted in a threefold elevation of p70S6k
phosphorylation, and 5 sets of 6 RM resulted in a sixfold elevation (i.e., double the
response). In the rodent study mentioned earlier, p70S6K phosphorylation continued
to increase with increasing "set" volume up to 20, although "sets" here cannot be
considered equivalent to human sets. In a fifth study, phosphorylated S6K were 19%
greater with 6 sets per muscle group performed in a training session versus 2 sets.
Overall, the anabolic signaling data tells us that "more is better" in terms of sets, but
it doesn't give us an optimal range or tell us when "more" becomes "too much."
Muscle fibers have nuclei, which are the control centers for these muscle fibers and
contain important genetic information. To repair or build new muscle fibers, you
need new nuclei. Enter satellite cells, which are dormant cells located outside of
muscle fibers. When a muscle fiber is damaged, satellite cells donate their nuclei to
allow the fibers to be repaired and grow. Thus, satellite cells are an important
component in the process of muscle hypertrophy. Thus, if set volume impacts
muscle size, then one mechanism through how it does so may be through satellite
cell activation.
Only one study has looked at the impact of set volume on satellite cell activation. In
this study, 3 sets of leg press and 3 sets of leg extension (6 sets for quadriceps total
done 3 times per week, or 18 total weekly sets) resulted in greater satellite cell
activation than 1 set of leg press and 1 set of leg extension (2 sets for quadriceps per
session, or 6 weekly sets). This was accompanied by a much greater increase in leg
extension 1-RM strength as well (48% versus 29%). This would suggest that a total
weekly set volume in the teens might be better than single digits, at least for legs.
In this study, researchers also looked at satellite cell activation in the trapezius, as
well as shoulder press strength. They did not observe any impact of set volume on
either satellite cell activity or shoulder press strength. However, given that the
trapezius is not a prime mover in the upper body exercises used in this study (seated
chest press, seated rowing, lat pulldown biceps curl, and shoulder press), the satellite
cell activity in the trapezius may not give us sufficient information as to the impact
of set volume on satellite cells in the upper body.
Overall, this data would suggest that a weekly set volume in the teens is likely better
for hypertrophy than single digits, at least for the legs.
So far, all of this data only tells us that, if you want to gain as much size as possible,
multiple sets per muscle group are better than single sets, more sets are better than
less (to a point), and weekly volume in the teens may be better than in the single
digits. But this is all based on extrapolation from data derived from muscle
biopsies. Ultimately, we need to look at what happens to changes in muscle size
when you put people on training programs with different set volumes.
A fair number of studies have been done over the past few decades, that have looked
at changes in muscle size when comparing different set volumes. Results have
varied, with some studies (like this one) showing more muscle gain with more sets,
while other studies (like this one) showing no significant difference with more sets.
Differences in outcomes between studies might relate to differences in study design,
in populations used, in training volume, in training frequency, etc. However, another
key factor that may explain the differences is one of sample size (i.e., the number of
subjects in each study).
To give you an idea of why sample size may impact the results, let's say you want to
do a study that compares low volume training to high volume training. You need to
know how many people you should recruit to your study. So, you do what is called a
power analysis. This gives you an approximation of how many subjects you will
need to successfully detect a particular difference between groups. To do a power
analysis, you need an idea of what sort of difference you are interested in seeing.
For example, perhaps you think that high volume training will give you double the
muscle gains. You then use data from previous research to get an idea of what the
typical level of muscle gain in a study happens to be, and how much it tends to vary
from one person to the next. This data goes into the power analysis, and you end up
with an estimate of how many people you are going to need.
Let's go through this power analysis exercise with some real world data. Direct
measurements of muscle size (like ultrasound) are superior to indirect measurements
(body composition techniques like DEXA), so we'll stick with data that uses those
types of measurements. Typical changes in muscle thickness, assessed by
ultrasound, tend to be around 5-10% over a typical 8-12 week study. So, let's say I
think a low volume group might experience a 5% change in muscle thickness, and a
high volume group might experience a 10% increase in muscle thickness.
Essentially, I'm guessing that I'll get double the gains with high volume over low
volume.
So what is the number of subjects that I need? Using data from a rest interval study I
collaborated on with Brad Schoenfeld, Menno Henselmans, and others, and then
running the data through some online power analysis software called GLIMMPSE, it
turns out I would need approximately 100 subjects per group to declare a 5%
versus 10% gain in muscle size as statistically significant, 80% of the time!!!!!! If
I reduce this to 50% of the time, I would still need about 50 subjects per group!
In other words, if I did 100 studies, and wanted to be able to declare a doubling of
muscle size as statistically significant in only 50 of those studies, I would need 50
subjects per group!!!!
Now, what is the typical sample size of most weight training studies? Maybe 8-15
subjects per group?
Let's look at the statistical power if you only had 10 subjects per group. Running the
same data through GLIMMPSE, I get a statistical power of approximately 30%.
This means that, with only 10 subjects per group, you will declare a 5 versus 10%
gain in muscle size as statistically significant in only 30 out of 100 studies!
This means that most weight training studies on volume are essentially set up to
fail to detect important differences. Changes in muscle size are small, and vary a
lot from one person to the next, and so you need HUGE differences between groups
to detect a difference over a typical 8-12 week study that only has around 10 people
per group. But the reality is that the impact of doubling your training volume isn't
going to result in 3-4 times the gains. It might result in a doubling of gains, but, as
you just learned, most weight training studies have sample sizes that are simply too
small to detect even that amount. This is why you see disparate results among
studies. Some will successfully detect a difference based on random chance alone,
while others will miss a difference, even if a true difference exists (in statistics, this
is called a type 2 error or false negative).
Here's an example of a possible type 2 error. Ostrowski and colleagues looked at the
effects of weight training set volume on muscle size. They compared three volume
levels: low, medium, and high. The following table shows the percentage gains in
muscle size, as well as the effect size (a measurement of the meaningfulness of an
effect), for each group:
In this study, double-digit weekly set volumes resulted in approximately double the
muscle gains (the orange cells), but these differences were not statistically
significant. Why would this happen? This study only had 9 subjects per group, so
there's a good chance this is simply a false negative or type 2 error.
When I did this analysis, I found that multiple sets per exercise were superior for
hypertrophy compared to single sets. Both categories of 2-3 sets per exercise and 4-
6 sets per exercise were greater than 1 set. The magnitude of the average effect size
(again, effect size is a value assessing the meaningfulness of an effect) tended to
favor 4-6 sets over 2-3 sets, although that difference was not statistically significant.
Here's a chart from the study:
Now, there were a number of limitations to this analysis. First, there were only 8
studies that met my inclusion criteria. There were only 2 studies that involved 4-6
sets per exercise. There wasn't enough data to determine if there were differences
due to factors such as training status (i.e., trained versus untrained subjects). I was
the sole author on this paper, so there was no one available to double check my
work, and thus it's always possible some bias or error could sneak in. This analysis
only tells us about volume in a single session, and not overall weekly volume.
Finally, sets per exercise is not the same thing as sets per muscle group. For
example, you could do 1 set of incline press, 1 set of flat press, and 1 set of decline
press, and that's 3 sets for your chest, but in this analysis it would be categorized as 1
set. Still, more sets per exercise will still mean more sets per muscle group, so this
meta-analysis clearly showed that your gains increase as your volume increases.
Six years later, more studies on hypertrophy had come out. Brad Schoenfeld, Dan
Ogborn, and I discussed doing an updated meta-analysis, with all of the new
research included. In this analysis, we would have multiple individuals coding the
studies to serve as a double-check on accuracy, and help reduce bias. We would also
look at volume in terms of sets per muscle group per week, rather than sets per
exercise. Our results were published in the June 2017 issue of the Journal of Sports
Science, and we confirmed a relationship between training volume and hypertrophy.
I'll note that since that paper was published, we did discover an error in how
volume was classified for a study by Correa and colleagues; we erroneously
classified weekly volume as 9 sets in the high volume group and 3 in the low
volume group, but it in fact was 18 in the high volume group and 6 in the low
volume group. While this did not materially impact the conclusions of the paper, it
did impact the dose-response relationship so that it wasn't apparent as you moved
from <5 sets to 5-9 sets (but it still existed for higher volumes). I'm reporting the
fixed numbers to you this review, so they are slightly different from the published
paper.
When categorizing the weekly set volumes into <5, 5-9, and 10+ weekly sets, there
was a distinct advantage to double digit weekly set volumes, with nearly double the
gains (ES = Effect Size).
We also divided weekly volume into less than 9 sets, or 9+ sets. Again, the higher
volume was better.
Finally, here is a forest plot of all the studies included in the analysis. A forest plot
tells you whether high volume or low volume was favored in each study. If a dot is
to the right of the center line, it means that study tended to favor high volume. If it's
to the left, it tended to favor low volume. The further to the right or left, the stronger
the effect. The size of each dot represents the weight of the study in the analysis;
studies with larger sample sizes get more weight. You can see that nearly all of the
studies are to the right of the center line, indicating most studies favored high
volume. Some are dramatically to the right of the line. In fact, only one study is to
the left of the line. This is consistent with an impact of training volume on
hypertrophy. If there was no impact of volume, then studies would be more
randomly distributed around the center line, with some studies to the left, some to
the right, and some on the center. However, this is clearly not the case. The average
across all the studies is represented by the large black diamond at the bottom, which
you can see favors higher volume.
Diving Deeper
Since that meta-analysis was published, there is much more existing data on the
impacts of set volume on hypertrophy. Let's do some updated meta-analyses and
deeper dives into recent studies and see what we find.
For example, let's say study #1 compares 9 weekly sets to 18 weekly sets, divided
into three times per week. That's 3 versus 6 sets per session. Let's say study #1
shows a benefit to the higher volume.
Study #2 comes along and compares 9 weekly sets to 18 weekly sets, but only trains
once per week. That's 9 versus 18 sets per session. Study #2 shows a benefit to the
lower volume.
If I were to aggregate study #1 and study #2 together, they would appear to cancel
each other out. Both compare 9 to 18 weekly sets, but show the opposite results.
However, the two studies utilized different frequencies; it's very possible that study
#1 showed a benefit because the per-session volume was fairly low, and study #2
showed the opposite because the per-session volume became excessive in the highest
volume condition.
Thus, the previous approach I had used for meta-analysis (comparing higher versus
lower volumes in each study in a binary fashion, or performing a meta-regression
while ignoring frequency) is not a good approach. A better approach is to examine
whether there is an interaction between volume and frequency. If there is, then it
would indicate it is better to look at training volume on a per-session basis, rather
than a weekly basis.
If we were to test the inverted U hypothesis with a simple linear function, it would
suggest a flat line and no relationship between volume and hypertrophy. However,
this is simply due to the use of the wrong model. A more appropriate model would
be a quadratic function.
It's also possible that there isn't really a regression at higher volumes, but more of a
plateau or perhaps just slight regression. In this case, an inverted U or quadratic
function isn't appropriate. For example, perhaps our model needs to reflect that
there's a rapid increase in gains as you increase volume in the low end, with
diminishing returns in the higher
end. For example, rodent muscle protein synthesis data shows a rapid initial increase
followed by diminishing returns and a slight
regression.
In this case, a logarithmic relationship is probably the best, or perhaps a logarithmic
relationship for early set volume and a flat or slightly declining linear relationship
for very high volumes.
Getting Technical
Here's what I did. Now, this section is a bit technical, so you can skip it if you don't
care about methodology.
An effect size for each outcome was created by calculating the post-test mean minus
the pre-test mean, divided by the pooled pre-test standard deviation. For example, if
there were three levels of volume, then the pre-test standard deviation was pooled
across all three levels. I analyzed the data using what is called robust variance
random effects modeling for multilevel data structures. This probably sounds like a
bunch of statistical gobledygook to you, so I'll explain it in laymen's terms.
Basically, when you have a study, you can often have multiple outcomes from the
same study (like quadriceps and biceps data). You have to account for the fact that
those outcomes will be correlated, since they're from the same study (you can't treat
them as independent). This is where the "multilevel data structures" comes in; my
stats help account for this. Also, a "random effects" model, in laymen's terms,
essentially means that I can't account for every possible source of variance between
different studies, and that the "true" effect of volume may vary somewhat randomly
(rather than be a single value), so I need to incorporate that uncertainty into my stats.
Now, each study is not weighted the same. Obviously, a study with a larger sample
size (and hence more precision) should get more weight in the analysis. So, each
outcome was weighted by the inverse of its variance (i.e., less variance = more
precision = more weight).
Unlike my previous iterations of the analysis, I primarily ran set volume as a
continuous variable. I took per-session volume and fit linear, quadratic, and
logarithmic functions to the data to determine the best fits. Also, because rest
intervals may impact the relationship between volume and hypertrophy, I ran
separate analyses for studies using long rests (2+ minutes) and short rests (<2
minutes). I used meta-regression to analyze the data.
Meta-Regression Results
With short rest intervals, hypertrophy increased with increasing volume up to 15-16
sets per session, albeit with diminishing returns. This was true for both trained and
untrained subjects.
For long rest intervals, a breakpoint model fit the data best, with a combination of a
logarithmic curve and a straight line. This model showed hypertrophy to increase up
to 6 sets per muscle group, followed by a very gradual regression after that. None of
the studies with untrained subjects exceeded 6 sets per muscle group per session, and
there were very few data points with less than 6 sets in trained subjects. Thus, I
haven't separated it out by trained and untrained subjects, although an analysis of
specifically trained and untrained subjects yielded curves with coefficients (the
"multiplier" in an equation or model) similar to the combined data.
This data would suggest that, with long rest intervals, gains level off or maybe even
regress beyond an average of 6-8 sets per muscle group per training session. I stress
average here because there's data showing that individuals may deviate substantially
from this.
You can also see how rest intervals impact the upper limits of training volume. With
short rest intervals, you have to do approximately twice as many sets per session as
with long rest intervals to maximize gains. For a more detailed analysis on this,
check out this Weightology research review.
Summarizing the Meta-Regression Results
Overall, this data suggests a threshold of somewhere around 6-8 sets per muscle
group per training session when using long rest intervals. You may have to do
approximately double this amount when using short rests.
It's also important to note that, in the previous graph, there is a lot of variance.
Within any given set volume, there is a huge range in effect sizes. For example, with
a per-session volume of 6 sets per muscle group, effect sizes range from around 0 to
around 1.5. This demonstrates why one should be wary of drawing too much
conclusions from one study when it comes to set volume and hypertrophy; different
studies with the same set volumes per session can have widely different results. This
also shows why meta-analysis and meta-regression are so important; it allows you to
assess the overall trend.
Finally, I can't stress enough that these are very rough averages. Just because the
average across studies suggests a 6-8 set per muscle group ceiling with long rests,
doesn't mean that's true for all individuals. Some individuals may have volume
ceilings much higher than this. For example, in this study that I reviewed in my
research review, some subjects had volume ceilings up into the 30+ weekly set
range. They trained twice per week, so some subjects had volume ceilings roughly
double the 6-8 set ceiling, even when training with longer rests. However, the
averages in that study didn't show much benefit beyond 20+ weekly sets. This is
why averages can be misleading. Averages can be a starting point when it comes to
program design, but don't treat them as a holy grail.
In the original version of this guide, I used some strength data by Marshall et al.,
Ostrowski et al., and Baker et al. to make some inferences about the dose-response
effect of volume on hypertrophy. I assumed a strong relationship between strength
and size gains in trained individuals, and used the strength gains in those studies as a
proxy for hypertrophy. However, as I've written in the Progression Guide, the
relationship between strength and size is not as close as once thought, even in trained
subjects. In fact, in a recent study that I was a co-author on, there were no
differences in 1-RM bench or squat gains between three levels of volume (1, 3, and 5
sets per exercise) in trained subjects. This is despite the fact that there was a graded
dose response in hypertrophy. There was also no correlation between strength gains
and size gains in that study. The following charts show the strength gains and
muscle thickness gains; you can see no difference in 1-RM or endurance gains, but a
graded dose response in three out of the four muscle groups tested.
Impact of Volume on 1-RM and Endurance Gains (1, 3, or 5 sets per exercise)
Dose-Response Impact of Volume on Hypertrophy (Sets Per Exercise)
Thus, strength data cannot be used to make inferences about the impacts of
volume on hypertrophy.
In the original version of this guide, I had suggested that an optimal volume lie in the
12-18 weekly set range, and that weekly set volumes of 20+ likely would not result
in further gains. This was based on the following observations:
Finally, a study performed was performed on high volume training by Haun and
colleagues. Training lasted for 6 weeks. Subjects started 10 sets per exercise per
week (split into three sessions per week), with approximately one compound
exercise per muscle group (squat, bench press or overhead press, SLDL and lat
pull). Subjects did 10 reps per set at approximately 60% 1-RM; the average Reps In
Reserve (RIR) was around 4. Set volume was progressed each week, so that subjects
were doing 32 sets by week 6. Lean mass (assessed via DEXA) significantly
increased by 2.2 kg by the end of the study. The researchers used bioelectrical
impedance spectroscopy (BIS) to estimate the amount of intracellular vs.
extracellular fluid, and subtracted the extracellular fluid amount from the DEXA lean
mass to estimate how much tissue gain was "true" tissue gain, versus extracellular
water (which might be considered edema or swelling from the high training
volume). The researchers found that, while lean mass continued to increase with
progressively higher volume, there was no longer a significant increase in lean mass
from the midpoint of the study to the end when the results were corrected for
extracellular water.
This study has been used as evidence to indicate anything beyond 20 weekly sets
isn't effective for hypertrophy. However, there are a number of problems with this
conclusion:
Let's take a closer look at the dose-response studies that involved very high weekly
set volumes.
• In the study by Raedelli and colleagues, the researchers compared 1 set, 3 sets,
and 5 sets per exercise, done three times per week. Sets were performed for 8-
12 reps to failure, with 1.5 - 2 minutes rest. The subjects performed bench
press, leg press, lat pull down, leg extension, shoulder press, leg curl, biceps
curl, crunch, and triceps extension. If you count the pushing movements
towards tricep volume, and the pulling movements towards bicep volume, the
total weekly volume for each muscle group was 9, 27, and 45 for triceps, and
6, 18, and 30 for biceps. The study was carried out over a 6 month period, and
was performed on untrained subjects. It was one of the most well-controlled
studies on volume, given that it was performed on Brazilian Navy cadets
confined to an aircraft carrier. Also, it was carried out for 6 months, compared
to the usual 6-12 weeks of other studies. Here are the percentage gains for
each muscle group and each volume level:
There was a clear dose-response effect in terms of volume in this study,
especially in the biceps. In fact, the gains in muscle thickness observed with
30-45 weekly sets were 3-4 times what is typically seen in studies (most studies
show around a 5% increase in muscle thickness). Now, one odd result of this
study was that there was hardly any increase in tricep muscle thickness for a
volume of 27 weekly sets. This is at complete odds with other studies that show
significant gains in tricep thickness with much lower volumes in untrained
subjects. The sudden jump to nearly a 21% gain at the highest volume is also
very strange. However, this does not invalidate the study; as I've written
elsewhere, you can get odd results like this from random chance alone. Overall,
the study did support an effect of volume, and no plateau was observed for
weekly set volumes of more than 20. It should also be noted that the
researchers examined fat-free mass gains. There were no significant differences
between groups in fat-free mass gains; however, this data is likely not reliable
since it was assessed using skinfolds, which are not a reliable technique for
assessing changes in fat-free mass. Also, the control group showed a significant
increase in fat-free mass; this indicates potential error in the measurements as
you would not expect the control group to show an increase.
The big strength of this study was that it was mostly a replication of another
study, and the results were similar. Replication is an important concept in
science; when independent research groups can replicate results, it gives more
credence to the findings. This study, along with Radaelli, provide evidence that
the upper limit for weekly volumes may be higher than previously thought. You
can also see the dramatic variation in how people respond to any given volume.
For example, in the low volume groups, some people had higher gains in
muscle thickness than some of the people in the highest volume groups.
If we classify subjects into "low responders" based on whether they met the
"smallest worthwhile change" (which is at least 0.2 standard deviation units, or
a "small" effect size), then the percentage of low responders decreases as you
increase volume. In fact, there were very few low responders in the highest
volume condition.
The same holds true for high responders (define as improving by at least 0.8
standard deviation units, or a "large" effect size). As volume increased, the
percentage of high responders also increased.
This data would suggest that, for people who are "hardgainers", an increase in
volume may be necessary. This is at odds with the conventional wisdom that
hardgainers require less volume and more recovery. However, this data is in
agreement with research on endurance training, where non-responders do show
a response when subjected to more volume. Now, there are some limitations to
this type of analysis. The percentage of responders could be a totally random
phenomenon; if you were to replicate this study, you might end up with no
apparent responder/non-responder effect.
One limitation of this study was that subjects were allowed to train outside of
the study. While the researchers asked the subjects not to do any sort of pulling
or bicep movements, and while the subjects did record their own training
journals outside the study to ensure this wasn't happening, it can't be ruled out
that they may have been doing some other pulling or bicep work. Another
limitation is the short duration of the study (6 weeks); it is the shortest study
among all the dose-response studies on volume. It is possible that longer
durations could show differences; for example, one study found no significant
difference in hypertrophy between 12 and 4 weekly sets after 6 weeks, but did
show a difference after 20 weeks. A third limitation is that the groups used
different frequencies; the low volume group trained biceps once per week, while
the other two groups trained biceps twice per week. While frequency does not
appear to impact hypertrophy much on a volume equated basis, it may impact
hypertrophy when weekly training volumes become high as I pointed out earlier
in this article.
Why are there differences in the outcomes of these dose-response studies? Three
show a benefit to very high weekly volumes (two of which had very similar study
designs), while three do not. There are a number of potential explanations for this:
• Random chance. As I have written about here, you can get different results
in training volume studies due to random chance alone, even if study designs
are identical (which in this case, they are not). This is especially true when
you have small sample sizes (most resistance training studies don't have more
than 9-20 per group), and you're measuring something that shows tremendous
variance from one person to the next, like hypertrophy. In that article, I did a
statistical simulation of 5 different studies that sampled from populations that
showed a graded dose-response effect of volume on hypertrophy. The studies
all had different outcomes, as you can see in this set of charts:
Thus, it's possible that one factor behind the different results of these studies are
due to random chance, or a combination of random chance and different study
designs. This is why meta-analysis and meta-regression become important.
• Short vs. Long Rest Intervals. The three studies showing a graded dose-
response relationship up to very high volumes involved short rest intervals of
around 90 seconds or less. The studies that showed a plateau at lower
volumes had rest intervals of 2+ minutes. Longer rest intervals usually result
in more hypertrophy than short rest intervals for the same number of sets. This
appears to primarily occur with compound movements, and central fatigue
may be a mechanism (although there is debate about this). The use of short
rest intervals on compound movements may inhibit recruitment of high
threshold motor units (which have the most capacity for hypertrophy) due to
central fatigue. When you train with short rest intervals, you have to do more
sets to make up for this. For a more detailed analysis of this, check out this
research review as well as this one.
• Previous Training Programs. The training program a subject is on prior to
participating in a study may impact the subject's response to the study. A
subject who has already been training with high volumes may not have the
same response as an subject who had been training previously with low
volumes. Also, the size of the volume jump may impact gains. Differences
among studies may relate to the types of programs subjects were on before
embarking on the training, and which groups they were randomized to.
It is also possible that the differences between studies could be due to a combination
of some or all of these factors.
Finding Your Individual Volume Ceiling
The guideline of 6-8 hard sets per muscle group per session is based on averages
across multiple studies. As I mentioned before, individual volume ceilings may be
substantially higher for some people. So how do you find your own volume ceiling?
One method is to use small increments in volume and use progress as a guide when
to stop. Start with a low volume of training. When progress stops, increase weekly
volume by 20%. For example, if you're doing 8 weekly sets (4 sets twice per week),
increase it to 10 (5 sets twice per week). This should stimulate further progress.
Once you hit a plateau, increase weekly volume again by 20%. If an increase in
weekly volume of 20% fails to stimulate further progress, try one more 20% jump. If
those two successive 20% jumps fail to stimulate further progress, then you've likely
hit a volume ceiling for that muscle group.
What do you do when you've hit a volume ceiling and aren't progressing anymore?
Volume cycling might be the answer.
However, there is a limit to how much you can increase volume to achieve further
gains. As suggested by the inverted U hypothesis, at some point gains will plateau or
regress if volume becomes too high. Thus, at high training volumes, increasing
volume is no longer an option once a plateau has been reached. In this situation,
dramatically decreasing volume is likely the best option. This would theoretically
have the following effects:
• It would allow cumulative fatigue to dissipate, resulting in the expression of
new strength gains that may have been masked during the cumulative fatigue
of the high volume period.
• It would allow for the maintenance of the new size gains, while
simultaneously re-sensitizing the muscle to a future volume stimulus.
The amount of set volume needed to maintain size is much smaller than the amount
of volume needed to increase size:
It's also possible that gains may continue for a period of time during a reduction in
training volume. In the study by Bickel and colleagues that I mentioned earlier,
subjects continued to gain size when they cut volume from 27 weekly sets to 9
weekly sets (but not 3 weekly sets). Now, this study was on untrained subjects, but it
at least raises the possibility of continued gains during the initial periods of volume
reduction.
Given this limited data, we can hypothesize that volume cycling may be beneficial to
maximizing hypertrophy over time. Set volume is increased over time until a
maximum effective stimulus is achieved. You stay at this volume until performance
plateaus, and then dramatically reduce volume for a period of time. You then start
the cycle again. This approach is similar to the approach of cycling between
minimum effective volume and maximum recoverable volume recommended by
Mike Israetel and Renaissance Periodization. One primary difference from their
method is that you use performance as a gauge as to when to stop a high volume
cycle, rather than having a preplanned number of weeks.
1. Begin with a low training volume (for example, 2-3 sets per muscle group or
4-6 weekly sets).
2. Add sets per muscle group or per exercise over time (such as once per week,
or per session as long as you don't experience next-day soreness). Some
research suggests a 20% increase in set volume is appropriate.
3. Continue adding sets until you hit a plateau.
4. If two successive 20% increases in volume fail to stimulate further progress,
then you've likely hit a plateau. Reduce volume back to near the volume is
step 1. You may continue to notice strength improvements during this time as
cumulative fatigue dissipates.
5. Continue training at low volume for a period of time to allow your muscles to
re-sensitize themselves to a new volume stimulus. The amount of time will
likely depend upon how you feel and how your gym performance is doing. If
gym performance starts to regress during the low volume period, increase
volume a bit.
6. Repeat step #2 and ramp volume back up again. Continue cycling between
periods of low, medium, and high volume.
An alternative process would be to only increase volume when you hit a plateau as
described in the previous section "Finding Your Volume Ceiling." For example, you
stick with low volume until performance is no longer improving. Once you hit a
plateau, you increase volume by 20%. You continue to increase volume by 20% for
every plateau until two successive volume increases fail to further stimulate
progress. Then you go back to low volume and start the cycle again.
This process can be used in the context of body part specialization (discussed later in
this article). Perform a volume ramp with one or two muscle groups, while keeping
all other muscle groups on low volume maintenance. Once the high volume cycle is
finished for those one or two muscle groups, return those muscle groups to low
volume, and then begin a volume ramp for one or two other muscle groups.
Bear in mind that this is all speculative and hypothetical. We need more research
examining the impacts of varying set volume over time.
Unfortunately this was the only study performed on trained subjects. Barcelos and
colleagues compared 3 sets of leg extensions performed 2, 3, or 5 times per week (6,
9, and 15 weekly sets) in untrained subjects. While changes in muscle size tended to
be the greatest in the highest weekly volume group after 4 weeks, the other groups
caught up so that by the end of 8 weeks, changes in muscle size were similar.
Again, individual results may vary from the averages..This same study by Barcelos
showed about a third of beginners benefited from an increase in frequency, another
third benefited from a decrease in frequency, and a third showed no additional
benefit to either one. Thus, with 2/3 of the subjects showing either a benefit or
neutral effect of lower frequency, beginners are best erring on the side of low volume
and frequency for their hypertrophy programs.
For experienced individuals, a method of volume cycling using frequency could start
off with 5 sets once per week, and then progress to 5 sets twice per week after 6-12
weeks or a plateau is experienced. After another 6-12 weeks or a plateau, frequency
is increased again to three times per week (15 weekly sets). A final overreaching
phase could then be undertaken with 5 sets performed 4 times per week (20 weekly
sets). Then frequency can be reduced back to 1-2 times per week to begin another
volume cycle.
In other words, subjects who were good responders to low volume also tended to be
good responders to high volume. Subjects who were poor responders to low volume
also tended to be poor responders to high volume (even if the response was
improved). This suggests that genetics are the ultimate dictator of how much muscle
you'll gain, regardless of your training volume. Some people will grow a lot no
matter what type of training they do, and some people won't grow much no matter
what type of training they do. While increasing volume may help with your
response, it is unlikely that increasing volume will turn you from a hardgainer into
an easy gainer. Rather, it is more likely you'll just turn into less of a hardgainer.
That's not to say you won't get improvement from increasing volume if you are a
hardgainer. If you look at the above graph, there were certain individuals who had a
much better response with more sets (such as one individual who went from a 2%
change in muscle size with 2 sets per session to nearly a 10% change in muscle size
with 6 sets per session).
In this same study, the researchers found that the subjects who responded the best to
higher volume had a greater accumulation of total RNA in their muscles. This was
indicative of greater creation of ribosomes, which serve as the site for protein
synthesis.
You'll notice that, in all of this, a set of direct isolation work (like a biceps curl) is
treated as a set count of 1, and indirect work (like a row) is also treated as a set count
of 1. The question is whether counting direct and indirect movements as 1:1 in
terms of sets is valid. Unfortunately, there's no research to guide us to the "real"
ratio (assuming there is one). In one study, it was shown that subjects tended to
recover faster from single joint lifts compared to multijoint lifts, suggesting that
isolation movements may be less stressful than compound movements and possibly
benefit from more volume and frequency. However, other data suggests that
recovery from single joint exercise may be slower than multijoint exercise, which
would tend to support the idea that a set of compound movements shouldn't be
counted as "1 set" for muscles like triceps. Also, muscle activity in supporting
muscle groups (like triceps in a bench press) may not be maximal compared to a
single joint movement, which would tend to question the 1:1 counting method.
Overall, it is not clear whether counting direct and indirect volume as 1:1 is the best
method. Nevertheless, there is very little data to suggest any other method, and
anything else (like counting each compound movement as a "half set") is based
purely on speculation. Thus, until the data clearly shows otherwise, it is likely best
to use the 1:1 counting method. This is the same recommendation put forth in a
review paper on this topic by Brad Schoenfeld, Cody Haun, Eric Helms, and others.
The Practical Limitations of Very High Volumes: A Personal Experiment
Even if very high volume training may be useful in certain situations, and even if
one can tolerate such training, one must consider the practical limitations of trying to
train with such volumes, especially in regards to time.
In the high volume training study performed by Schoenfeld, me, and others, the
average training time per session for the highest volume group was 68 minutes. The
subjects performed 7 exercises, for 5 sets each, for a total of 35 sets per session.
However, it's important to note that this time frame of 68 minutes may not be
realistic when applied to someone training in a regular gym. In a resistance training
study, you have research assistants pushing you along, and also helping to get
weights set up for you. There's also no waiting for equipment.
Contrast that with a real-life gym situation, where you don't have anyone hurrying
you along from one exercise to the next, and no one is setting up your weights for
you. I decided to try an experiment to see how long my training sessions would be,
if I tried to do 5 sets per exercise so that I was achieving around 30 weekly sets for
most muscle groups. I started out at 1 set per exercise, and would slowly add sets
over a number of weeks to allow my body to adapt to ever increasing volume, and
to help minimize any soreness. When I got to 5 sets per exercise, I was doing the
following in a whole body workout (all sets had 90 seconds rest between them):
This session (35 work sets total), including warmups, took me about 1 hour and 50
minutes to complete. Thus, this is a fairly long workout, longer than what I like to
do personally (I don't like to exceed 90 minutes). At three times per week, this
would be about 6 hours per week of training. Keep in mind that doesn't even
achieve a full 30 sets per muscle group for all muscle groups. Back only amounts to
15 weekly sets. There is no calf work, hamstring work, or direct shoulder work.
Now, one difference between my experiment and the Schoenfeld study is that I
utilized a number of isolation exercises. Nevertheless, there is a fairly large
difference between my experience and the study. My own experience is probably
more relevant to what would happen in real life, as people generally don't have
others pushing them along or setting up weights for them.
This brings up the idea that, for most people, achieving very high volumes for most
muscle groups is going to be unrealistic, especially if you're using free weights
where it takes time to set up. Thus, the most realistic way to achieve high volumes
is through the use of specialization, focusing on 1-2 muscle groups while training
everything else in the low to moderate volume range.
Now, there are a number of limitations to these conclusions:
• I may sound like a broken record here, but this is based on average responses.
Individual responses to differences in volume can vary from the overall
average dramatically, and thus volume needs will vary from one person to
the next.
• There may be some benefits to cycling volume (similar to the Renaissance
Periodization method) and having volume "re-sensitization" periods, but this is
speculative and the data is limited at this point.
• These results only apply to set volumes involving moderate to high
repetition ranges (approximately 8 reps or more) to failure or near failure.
• There is insufficient data to tell us how volume needs might vary based on
factors such as age, training status, etc. Age may be a particularly relevant
factor here, as recovery time may increase with age. It should be noted that
the studies involving 21+ weekly sets all involved young subjects in their
20's. Older individuals may not be able to tolerate such volumes.
• There is insufficient data to tell us how volume needs might vary between
different muscle groups (such as upper versus lower body), if they need to
vary at all. Currently most of the data suggests there is no benefit, but more
research is needed.
• There is insufficient data to tell us how volume needs might vary between
different types of exercises (like compound versus isolation, or exercises that
load a muscle under stretch versus ones that don't). It's possible that some
exercises may need less volume; for example, exercises that load a muscle
under stretch (like an overhead dumbbell triceps extension) are more
damaging to muscle tissue than exercises that don't (like a hip thrust), so it
might be easier to "overdo" it in terms of volume with the loaded stretch
exercises.
• Weekly set volumes of 21+ are very high, and are going to be more than
many individuals can tolerate or have time for. Remember that significant
gains are achieved with low to moderate volumes. You must consider the
needs of an individual, including schedule, volume tolerance, recovery
ability, available time to train, importance of achieving maximal
hypertrophy, injury history, etc.
• It cannot be ruled out that individuals training with low to moderate volumes
may eventually achieve the same gains as higher volumes, but over a much
longer time frame. However, there is no research examining this.
• Depending upon an individual's available time to train, it may be difficult for
someone to achieve 21+ weekly sets for most major muscle groups, even if
he/she can tolerate the volume. In situations like these, it may be best to focus
on a couple individual muscle groups, training them with very high volume,
and using a maintenance volume on the other muscle groups. Then, after a
period of 2-4 months, switch to emphasizing some different muscle groups.
This is a strategy that has been recommended by Bryan Krahn,
• Most training studies only last 8-12 weeks. It's possible that, if you're training
with 21+ weekly sets for a muscle group, you may not tolerate such volumes
for longer periods of time (although the study by Raedelli and
colleagues lasted for 6 months and involved weekly volumes of 30-45 sets for
the arms). This is where the needs of the individual have to be considered,
including many factors mentioned before (training history, injury history, how
close sets are being performed to failure, types of exercises being used, etc).
• Conclusions in science are always tentative. The conclusions of this review
may change as more data is accumulated (this review has already undergone
four major revisions as new data has come in!).
It's interesting to note, anecdotally, that some top trainers in the industry use
specialization routines and weekly set volumes of 30-40 to achieve maximum
hypertrophy in target muscle groups. Bret Contreras often programs 30-40 weekly
sets for glutes in his clients, and Bryan Krahn has mentioned using specialization
and 30-40 weekly sets to maximize hypertrophy in a particular muscle group. My
friend Jacob Schepis also embarked on his own 10-month high volume arm
specialization routine, where biceps and triceps each got about 30 weekly sets (about
15 direct and 15 indirect). Here is visible evidence of his results (and this is in a
well trained individual!):
So how might you apply this information to structuring a training program for
maximizing hypertrophy? Here's one example of how you might structure a
program that uses the best "bang for your buck" range of 10-20 weekly sets per
muscle group. This particular example is a 4-day upper/lower split; most muscle
groups are trained via combination of compound and isolation movements. Total
weekly set volume is 16 for most muscle groups. Sets per muscle training session
are around 8. Sets are stopped around 1-2 reps short of failure to allow for better
recovery, and repetitions and exercises are varied to help reduce joint stress.
When trying a program like this, considering using a volume ramp method. Start
with 1-2 sets per exercise. Either on a weekly basis, or as you hit plateaus, add one
set per exercise. Continue to do this until you hit 8 sets per muscle group or until
you've done two successive 20% increases in set volume with no further progress.
Once you've hit a plateau that you can no longer break through, then consider
reducing volume again.
In this example, upper body is trained three times per week (one day is a dedicated
arm day) and lower body twice per week. Total arm volume is approximately 26
sets for triceps and 32 sets for biceps (counting both indirect and direct
movements). Other muscle groups are in the 12-18 range. Sets per training session
does not exceed 10 per muscle group.
Wrapping It Up
Well, that about does it for the most thorough review on training volume and
hypertrophy that you'll find anywhere. You can be sure that this will be updated as
new research becomes available. Conclusions in science are always tentative, and
based on the best available evidence at the moment. In the case of set volume and
hypertrophy, more is better up to around 6-8 hard sets per training session with
long rests and twice as much with short rests. High weekly volumes (20+ weekly
sets) give best results when split into frequencies of at least 3 days per week. Of
course, this is based on averages, and individuals may respond very differently to
changes in volume compared to the average. It's also important to point out that 12-
18 weekly sets probably gives you the best bang for your buck in terms of
hypertrophy relative to the time investment when hitting each muscle 2-3 days
per week. If you're looking to do some very high volume training, specialization is
the most realistic method of achieving high weekly volumes for a particular
muscle group. Also, regardless of how you program volume, the needs of the
individual must be considered.
Keeping up with the research is tough, so let me do the work for you. Consider
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