8 THINGS ABOUT HEMOFILIE

1. Hemophylls are common hereditary pathological bleeding produced by the deficit of one of the
coagulation factors VII or IX. The severity of the factor deficit determines the probability and
severity of the snack. Hemofilia is a chronic, life-long disease.

2. Hemofilia is a congenital affection, which is transmitted by sex X chromosome, so it is

transmitted from the woman but clinically manifests only to the man. The disease has two forms,
the type A hemophyllia – factor VIII deficit and type B hemophyllia – deficit of coagulation factor
IX. Clinical manifestations often consist of muscle blood(hematomas), or joint(hemarthrosis).
These bleeding occurs in trauma identifiable by anamnesis, in lighter cases with lower deficits, or
spontaneously, in severe deficits.

3. Treatment is carried out with factor VII or factor IX, or plasma. A preventive treatment may be
made, prior to surgical or dental interventions, in situations where hemophyllia was diagnosed
before they were performed.

4. Hemophylia is of two types:

• hemophyllia A-in which the coagulation factor VIII is missing
• B-in hemophylline missing coagulation factor IX

5. The signs and symptoms of hemophyllia:

• bleeding – patients with hemophylline bleeding in tissues(for example, hemarthrosis – hemorrhage
at the joint) and bleeding occurs after a certain type of trauma
• pain – often occurs with the beginning of bleeding, but sometimes it may occur before other
symptoms or symptoms occur.
• Chronic or recurrent hemarthrosis can lead to synovitic and arthritic arthroats
• the patient with hemophylphy does not bleed faster, but has prolonged bleeding
• Cranio-cerebral traumatism is an emergency due to the possibility of brain hematomas, and in case
of trauma, a coagulation factor must be administered preventively.

6. Prothrombin time(PT), which measures other coagulation factors other than hemophylphilia.
Most people with hemophylphy have normal results in this test. PT may be abnormal in another
condition causing bleeding.
• Part-activated time of thromboplastin(APTT) measuring the factors VIII and IX of coagulation,
which are absent or not functioning properly in people with hemophyllia. This test cannot determine
which type of hemophylline is(A or B) or if the defect is at factor VIII or IX. A person with
hemophyllous has an abnormal result of his APT-his.
• Test of the coagulation factor, which determines the hemophyllum severity by measuring the
activity of factor levels VIII and IX in the blood, which indicates the quality of the coagulation
factors and their function.
• mixed coagulation tests in which the harvested plasma is mixed with normal plasma to see if it
reaches a normal level of coagulation factors. If it does not reach a normal level, inhibitors to
coagulants VIII and IX are present in the harvested plasma. In this case, we are talking about the
haemophilia we have gained.

7. The child shall be tested after birth for hemophyllia A from a sample of blood taken from the
umbilical cord. Testing for hemophylline B in neonates is not effective as newborns have a low
factor IX. Testing for coagulation factor IX is more effective after the child is 6 months old.
8. Hemophylical patients should avoid aspirin and AINS(non-steroidal anti-inflammatory)
suppressing the platalm function. Regular dental care is essential to avoid dental extraction or other
dental surgery. Medicinal products must be administered orally or in-venous, with intramuscular
injections potentially leading to hematomas. Hemophylical patients must be vaccinated against
hepatitis B. Patients with hemophylline should maintain a good health condition, constant weight,
and limit stress in the joints( stress in the joints may lead to hemarthrosis). They will also avoid
hard work, but will turn to a specialist physician to create a model of physical exercise for people
with hemophylline, as daily exercise increases muscle force and helps prevent hemorrhage.

References:

https://www.aspla.ro/hemofilia/
https://www.reginamaria.ro/utile/dictionar-de-afectiuni/hemofilia-a
https://www.reginamaria.ro/utile/dictionar-de-afectiuni/hemofilia-b