Hemostasis and Blood

Coagulation
Dr. Nivin Sharawy
Ass. Professor Physiology Department
Key Points

› Hemostasis

› Vascular Constriction

› Platelets Plug

› Clot formation
Hemostasis
VASCULAR CONSTRICTION
Platelets functional characteristics
Platelet Plug Formation
Platelet Plug Formation
Blood coagulation
Blood coagulation
Blood coagulation
Blood coagulation
Blood coagulation
Four interrelated steps to stop bleeding
Step 1 Physical Forces----------Chemical substance= compression &
vasoconstriction

Step 2 Formation of temporary platelet Plug:

Activation, adherence, aggregation, secretion, attraction

Step 3 Intrinsic + Extrinsic = stable Fibrin Polymer

Step 4 Platelet-------clot retraction

Plasmin--------Fibrinolysis
 Track the roles and components of
TAKE HOME the blood clotting phases, from
MESSAGES immediate actions to wound healing.
Explain the meaning of intrinsic and
extrinsic as applied to the clotting
pathways. How do the two pathways
differ from each other? Which steps
are common to both?
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