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SICKLE CELL CRISIS

Oxygenated RBC containing HbS

Polymerized HbS inside a deoxygenated RBC

Rigid sickled RBC  Necrosis


Ischemia  Organ dysfunction
 Acute pain
 Oxidative reperfusion
stress

 Fatigue
Vaso-occlusive event Haemolysis  Anaemia
 Cholelithiasis
 Endothelial dysfunction

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