Pharmaceutical Biotechnology educational field trip proposal

The main goal of pharmaceutical Biotechnology is production of therapeutical peptides and

proteins named biopharmaceuticals through recombinant DNA technology. A number of
biopharmaceuticals such as hormones, blood factors, thrombolytic, enzymes, growth factors,
interferons, vaccines, monoclonal antibodies and fusion proteins are produced for the
pharmaceutical market in a few expression systems like bacteria, Escherichia coli, yeasts,
Saccharomyces cerevisiae, animal, mammalian cell cultures — CHO, BHK and to limited
extend, in transgenic insects or insect cell cultures. High costs of such production and increasing
demand for the new biopharmaceuticals products for improvements of existing methods and
development of the new expression systems, like transgenic animals and plants.
Laboratory work and Observation in Ethio-Americal pharmaceutical industry, in Addis
Abeba

No List of activities Day/Time

1 Observation of Upstream process Cell banking system 1Day

2 Observation of Microbial cell fermentation 1Day

3 Observation of Downstream processing Cell production and initial product 1Day

concentration Filtration method Final product formulation

4 Observation of Biopharmaceutical products 1Day

1. Vaccine and adjuvant
2. Antibodies

5 Students’ daily Individual cost

Instructor’s daily per diem

6
7 Transport (double trip)

8 Total