Neuro-ophthalmic is one of the ophthalmological manifestations in patients with
HIV/AIDS. There are rare reports of neuro-ophthalmological manifestations of HIV-infected patients presenting with ophthalmoplegia and ptosis. The mechanism of neuro-ophthalmic disorders develop is heterogeneous but there are at least 2 main ways to cause neuro-ophthalmic disorders such as infected by the HIV virus itself or other factors. secondary infections such as opportunistic infections or neoplasms and inflammatory processes. Cerebral toxoplasmosis usually presents with subacute neurologic manifestations. The most common signs and symptoms were headache (38%-93%), focal neurologic deficit (22%- 80%), fever (35%-88%), mental confusion (15%-52%), seizures (19 - 58%), psychomotor or behavioral changes (37%-42%), cranial nerve palsy (12%-28%), ataxia (2%-30%), and visual abnormalities (8%-19%). These manifestations are not all found in patients with cerebral toxoplasmosis in HIV/AIDS patients. In this case report, the only manifestations that appeared were ophthalmoplegia and ptosis with normal funduscopy. The process of ophthalmoplegia in patients with cerebral toxoplasmosis is caused by cranial nerve palsy and due to opportunistic infectious and inflammatory processes. Although the manifestations of ophthalmoplegia in patients with cerebral toxoplasmosis are rare and neglected. Through this case report, we hope to be able to think about neuro- ophthalmic abnormalites caused by cerebral toxoplasmosis.