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    3 views12 pages

    Acta Pharm 1998

    Uploaded by

    Mala Zvijezda

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
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    uncas Coden: ACPHEE, ACTA PHARMACEUTICA ISSN 1330-0075, 1/98 PUBLISHED BY — IZDAVAC CROATIAN PHARMACEUTICAL society HRVATSKO FARMACEUTSKO DRUSTYO _ Acta Pharm, Vou 88 No.1 pears Zagreb, March 1998 ‘Acta Pharm, 48 (1998) 31-33 Oro paper Oxidation and reduction of sulfamethoxazole MONIKA Long (Oxidation and reduction of sulfamethoxazole (SMX) was makazne studied under various reaction conditions. Oxidation re- action by hydrogen peroxide in glacial acetic acid af- Faculty of Pharmacy and Biochemistry forded the coreesponding nitioso 1 (SMX-NO) os ain University of Zagreb derivative 2 (SMX-NO;). When the reaction was cate, 10000 Zagreb, Chat lyzed by methylthenium trioxide (MTO) the main prod uct was azoxy derivative 3 (SMX-AZ), Catalytic hydro. ‘enation of SMX with Pa/BaSO, resulted in amidine 4 (SMOGAD). The compound 4 was also prepared by hy- 210 °C. IR(KB1): Vinny 3437, 2922, 2852, 1616, 1477, 1405, 1348, 1268, 1177, 1091, 1042, 938, 845,746 Elemental analysis (7): caled. C 4633 H350 N 1621 $ 1237 CagHligNeOrS (51852) found 46.17 3.34 15.89 1232 THINMR (DMSO-

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