SKL1043 SPECTROSCOPY TECHNIQUES

ACTIVITY 5
MASS SPECTROSCOPY

1. Discuss the main principle of mass spectroscopy.

2. Draw a block diagram of mass spectrometer.

3. Ionisation sources can be classified into gas phase and desorption. Name two ionisation
methods for each type.

4. By using a diagram, explain how Electron Ionisation (EI) works.

5. Discuss the advantage and disadvantage of EI.

6. Electron Ionisation (EI) and Chemical Ionisation (CI) are the two most common
ionisation techniques for the formation of gaseous ions. Discuss why EI is regarded as
‘hard source’, while CI is regarded as ‘soft source’.

7. Distinguish between Atmospheric-Pressure Chemical Ionisation (APCI) and Electrospray

Ionisation (ESI) ionisation techniques.

8. Discuss the main advantage of Fast Atom Bombardment (FAB) ionisation method.

9. Quadrupole mass analyser is one of the most simplest and effective mass analyser.
Explain how it works.

10. Electron multiplier and Faraday cups are the two most common detectors for mass
spectrometer. Briefly explain how both detectors work.

11. A compound has a molecular ion peak at 130 mass units. What would be the mass for a
peak corresponding to an ion having undergone the loss of a methyl group (CH 3)?

SKL1043 Spectroscopy Techniques 2022 Activity 5 Azlan Kamari 1