NU dau hipoglicemie DAU hipoglicemie

-Metformin -sulfoniluree
-Tiazolidindione -meglitinide
-risc ↓ de hipo:
 Inhibitori de DPP4 (gliptine)
 Inhibitori de SGLT2
 Agonisti GLP1-R

Nu modif greutatea ↓G ↑G
Metformin Inhibitori SGLT2 Sulfoniluree (1-4 kg)
Inhib DPP4-gliptine Agonisti GLP1-R Meglitinide (1-4 kg)
Tiazolidindione (5-6kg)

Medicament preferat in NASH: Tiazolidindione

Med sigure in IR Med nesigure in IR

Inhib DPP4-gliptine Metformin
Inhib SGLT2 Sulfoniluree
Aduc beneficii fc renale!

Med care ↓ riscul C-V Med care ↑ riscul de IC

Inhibitori SGLT2 Tiazolidindione (retentive hidrica)
Agonisti GLP1-R SAXAGLIPTINA (inhib DPP4)

↑ riscul de pancreatita acuta:

Agonisti GLP1-R
Inhib DPP4