bedaquilinebed-ak-wi-leen(Sirturo)Do not confuse bedaquiline with quinidine or

quetiapine.BLACKBOXALERT QT prolongation may occur. Concurrent use with other drugs

that may prolong QT interval may produce additive QT prolongation. To be used only when
current treatment regi-men is ineffective. Placebo-controlled trial: increased risk of death (11.4%
bedaquiline vs. 2.5% placebo).uCLASSIFICATIONPHARMACOTHERAPEUTIC: Diaryl-
quinoline antimycobacterial. CLINI-CAL: Antitubercular.ACTIONInhibits mycobacterial
adenosine tri-phosphate (ATP) synthase, an enzyme essential for generation of energy in my-
cobacterium tuberculosum. Therapeu-tic Effect: Treatment of multi-drug resis-tant
mycobacterium tuberculosis (TB).PHARMACOKINETICSAbsorbed from GI tract. Peak plasma
concentration: 5 hrs. Metabolized in liver. Mainly excreted in feces. Protein binding: 99.9%.
Half-life: 5.5 mos.USESTreatment of pulmonary multidrug-resis-tant TB in adults 18 yrs and
older when other alterations are not available. No