Quay a IPAer =16 HaloalRanes ¢, Haloarenes Yes\s\s_ mcrobal dograd: wPig 1@F * sed in — \ndesires, Solvents for fon —yolar comp «Starling ravtenals im Org: comp: by sal tac. — teal Thy phoid | flato alldanes /aky) haide 4 ¥ replaces St in atyphake sys 7 Sprere OP —y i + Chloromphenicol Thyronine + comp of T - dehaeny Golire —— chioroquine. 2 Year malariae ~— \atothane + anaesthesia Ply Fhorinoted camp’ potential ood subshiule poioarenes /Arg! halide ex replaces “H’ 1 aromallic ring Is Cp? -* «x Csp*-* ClassiRahon No of tolgens — rrono +d: Ht» poly (tetra. pert et) | 3 WA Monoralo ~~ WN cep — ica | Gan | Avy bade niyhc Bereylic ae VS 1 CoHanty & Moca tt tached Mi Tae te to c=l 4o benzene 14 exto cal * af oF ning DS ~ Uk Sx A x Nona 6} ow Co wtp SHR 3Ri0H Nomenclature Haloalkanes CN: ally) halide lume: hdloaltone wie - «2% 40 adj c's \F 2 talogens 19 dihalo some \ LLY LENE ern —dibalide. eax’ to same C neu DIENE LA Aihalide haloarene Haloarenes wn ony\halide Lupe) Natwre oF C-% bond es ha Se § (yolonsed as % more Cledrongpive thao oO 4 & CEM c-I [bond lengh Fs atomic size)+ HCI welt ( + not ary! halide — o-C ond in pheno) has pally =" bond - difF 40 brea * easily access!be as x replaces OM sD pres: of haloa 9) Free radical halogenaton ahd a cl cracons) 243 crscrecdacs & Scat Is error & poly yalo comp: 1n MIA —> diff Seperate _bFram alttenss 1) Addition oF Hx XN ae x eee. Sp y a Si 4 —rtest to Aishinguish dy gese — 5 — SS econe offer COP G fea oe as brome Gives reddisn brown colour , padivon oF %2 ec, Vr> Fingelstan Rex: Ry + NaT Aapacelony pranaxt | (ppt im acetone aos Forward veac:) zt A Paar? > pr + Agy ‘Orefor iodo corp — Na Sa pe i a cf ondise Hx ft easy sepora\o Large diff 1m (reversible) & Fluoro comp — rok prep: high rede: OF "B7 atel= oO NoNno> ah in (O) cea) item cur He a |eorerna +N 2 watel” For icdo comp * 4 jr Ogis& shaking N21 BFL & F eo HALOARENE. note ©) 4B —> L For Floor comp, Balz - Scherran? reac: on x > On prs ©) 4 PRY +20 “Physical Proper Hes * Aly) halide — pure —CO\our\es & —pr/-z — colour when PO sedto hv zyaohle. comp -swee! smell BP. ¥ CH3C1/B ,QHSd , C1 CH2F —y gas ak Yoon, yep ays —'"9 [solids arity» molecukir Sue bp 1s hp & or Ries imer molecular artracHon 7 Vaumewmale, _dipae dale i po pry RBr 7RUPZRE be) + bp oF isomeric habewanes Yh branchiO3 He a woner > o- Im — isomers Bia grat fis better In orystol latHceea + Br IS |polychloro heavy ‘han a0 ie apensity to * oxi ts omic mass oF %b Solobilit » hala: — sgh! solu bilky IN 430 1 erergy-to overcome altrachay ble molewles =Yo break YW bond wy H20 released ashen new bond set up: ~ wear bond 2 Ness energy a faloalk: - dissolve OFF solven!s A-B > A-N& BB Cherrfical Reactions i Wweleophiic SUP + Reac- Brpiera) Soak defiaent regions Ni no = Jns - reac 2 ND replaces Exshg fan a rroleccle rpocleo philic SUI ciated by NU™ 3 \# 4 eee 7 i (leaving 9rP) a 5 hr =a so Amb dent nucleophiles sacks as WU IN 2 aitr ways 5 ? conwitsting 3! present nileites + ex! oyoride ca Z Sime by NY eros =0) jor bg © err e O— Rne oie ia Ten SRN c= mash nO NOD le leouyen Ree eo . aly! cyoid aug vere nitroalkanes Mechanisro a 6N2 | ea00° rucleo ormolecular @ 2M order winelics — vale of yeac « Bepands on con of both reac 4 ’ eH 2 on cee * >| ov-—;) a _ oy | —x Wy c es ” 4 MGI mu- \nteracke with airy) halide Cr bord weatens c-x bond. cleavage Coro tard For ¢ ayy ond. formnahon ¥ i, — t OW rove towards ally! talide — c-H bond mows same direc: — leaving s. gre roves ovny - Or ailocksformation + Fash reac oF Peco i greater ease of alky! halide cee le — oo by resonance E RI PRBP> Re Z7RE of plane polarised. Yignk ween ormary igh) 7 Nicol pris Pai sol’ A-form — Ch) — cl — polarimeter —> Optcal isomers + rolahon —r clockwise — Hdockwise — J — form - (~)—laevo opTicnL SOME RISHee ts oe ee ee a es Molecular asymmetry, enantiomers , chirqlitt —_ Aoryslal of some corp — Mirror Imayss m -oF both simages © * oplan\ rolalon equal wy mags OPP 'n dir: for aq sol q dve FO contigurahory pase argangenen) oF vatencies (4) a ne! a a corkon —ophaall! Wy achve achive (propan 2-0) are ditr - unsupersropesole Oe en yor Images — chiral * pasoper rn po sane mr — achiral — opheally 0 sopernpanbie: Mmrror mage CHIRAL eXarmples © 2-chlorchtane 2 2.3 —dihdroxy propanal © bromochlore ledomethane © 2-bromo Pro Panvic aud % sleransomers relaital +0 a other as mon —Superimposable enirror at ENANTIOHERS eal a / saith in wiaton only me. Phy “POP” Comme -t amie containing 2 enontomers — Zex0 oprical rotahon —Racemie mix [modi cation or \ | opHeatly inacHve (4) . # enanhomer XACEMISAHONY racemic mix > Retention | + preserving configuration 4 no bond in stereo certo same configurahen proken — product € vreac As OB Heecerc2—lot + HC __ 7 hme ob Bo On oe Ar }, \ oo ods @)-4-chioro - 2 -methy) botone O-2-methy) burand + diff in optical yohalion PF Inversion + Relenhon + Racomi salon ous ane Bey snversion dwt pretenWop) as 7 aencia, only A (ony 8) a \ v A+B A‘'B = 50 150.preferred product 16 ONE ” hydro) jondworn rece « ple borded car bon — in &l s greater alty) arr avached 40. dov er x Hq ether cs cra Hg BE Grignard Reagent (ORGANS — METALLIC COHP:) ae Gta -% =e > RgX 4 W20 ——~ RUT Mg (ow) X _= cowolenk YONIC + polar This highly tence fowuards H20 as ocll | +e plse® Reacts with Ort H20 Nee to ge He ~ (ooobe © ‘atores) “2RK+ ono Aap stboe> RR + 2NAK Wortz Reac-Reactions oF Haloarene s a =~ , . a 1 No® subst @ an ee soda t tant | a Sher «Gl =, o skaviaches to Sp* hy: °c” aForened by JelF~ ‘ 400 a ol pel s-char ons i ity Holds 4 por vesona” slabilis oa egal ea 0 e sore Hah esl mech“ ruled ok Panieacl — ni (baloall’) + conjugation of We ree sat d Reo sem =c-al (double bond paral) mes Perce ‘able NOE DA © cleavage difhalr a pe net ridh arene In Find = by oH QrP on F NOS A” reac yncona. BH eae a) ae ? “Noo 4U3R, & .” ee 9a wb om. oz ou Or 12} PAL r yyaost > wart p29, Ro. seeker LO No2r 2 Ros ne om ms posihon. © arlack, —e carbcalion _ reson: stabilised =No2 doesn’? oe efFe 02-0 o- Ip 4 1 Bae oF wing =ve J rerge 16 stabil = nv sed by N02 oz - no eftect 19 mm - position :- Fees oe On poshon Saige Apesnastanilise: “VS charge Eo"Giro? (reo\or) Reacon esith Metals BE hing A * Be Begs wre em alylarer ay halide — co cows 26y™ 4 2Na avy ebber: Ce ee ‘Dipreryl (analogers Comp)Hi chloro - methane. producon oF Freon rehgeranr (chloroform) R-22 Nearer — anaesthe nc lover repraced by ether puaiiar02 bY + acoda+ A sprosqene (porsorens qo*) _. stored \n closed dort coloured bolle — Resp AY oor > pre AGS : replaced by other Formulations \ ; Wherakon oF Free ¢ re natn] eee Jodine pa oe coniaining rodinea Pharrnaceuttcal als + refrigerants spo) remover © eaeroscl propellants +degreasing agent a feedsto? in CFC produc: fire extingusha- | ccly cleaning fluid causes \iver cancer, tm _| Teltachloromethane dizziness \ nausea, —— vomiting v permanent ‘eis cell dlareoge elloroFluor carbon comp + of methane/ethane stable ,Onreac- « Non-toxic . NEN = Corros We Say \qvehable CXlaF2 —Freon 12/ —ndustyal vse 40810501 propellants ZO wanstac fen Cy by Suse's Reac « + ve figeration ia x AC \ ) y winikale radical chain rene aditfoses into atososphere / | dstorbe 08 balance + Chonrated og \nsechade a yorid four TE — against mosquity + panned ih us LL spread malate. & \ree euienswe vse of DOT t v stopped \ ee mecks yesstonk 40 DoT a ethane. _ Tigh tox! > A ng cily do Fsh ro} mes obolised: og stoves In fatty Hosves fe (4a sob) a 7 Os