repvonlinecom —rgpvonlinecom rat No of Questions: 8] (Tat Na of Primed Pages: 2 RallNo.. PY-604 (CBGS) BPharm., VI Semester (Non-PCI Scheme) Examination, May 2018 Choice Based Grading System (CBGS) Biopharmaceuties and Pharmacokinetics Time : Three Hours ‘Maximum Morks 75 [Notes i)Atempéany five questions. Allguestons erry equal mars, 1. Derive mathematical equstions used 10 caleulate Pharmacokinetic parameters following JV. bolus ‘dministeation blood data assuming the drug follows one compartment opeamodel 2. Explain the various mechanisms of dug absorption though GIT, Diseuss about the factors which inluenee the drug sbsoetion trough GIT | Mention the objstive a bioavailability studies ad describe thephurmacokinstiemethed of eximatng biavalabiiy using plasma samples. Witea note oni vito-in viva comelatons 44. What do youmean by Nonlinee Pharmacokinetics? Discuss ‘the factors whic leadto nan-tineariy, Explain how Vg 20d ‘Ka determined inpatients v.504 C865) Pro ‘woo augusta yuosdta onlinecom epvonlinecom ‘5. Wile in eu on volume of dstrbuion and derive the equation indicating the relation berween protein-drug binding and ‘volume of istbacion. Explain the varius factors influencing ‘he protic drugbinding. 6. 8) What do you understand by Chronophurmacokintis; explains importance 1) Determine Ky and Vings by Lineweaver Burk pot nd ‘Woolf Eadie Augustinsson Hofsee plots 7. White shor notes on: ) Renal Clearanse ')_Drug sorption through non prom exera-vascularroutes ©) Compartment models 8. What ae the two methods for calculating K, from urinary ‘excretion data? Compare their merits and demerits ce ae i » oF Prent(cB08) ‘woo augusta yuosdta