Sror dox.an) orpaxaer cozaucosannoie aacaadot steacdyxapod- Roi epynnot aKcnepros u Ke OOKsaTeAbHO NpedCTUB.AReT pewe- nua wan opuyuarenyo nosuruxy Beesupuoi opeanusayuu adpacooxpanenun JnUgeMUONOru4eCcKUl HAg30p B NpOmUNaKmuKe W KOHMpone bochpocmpuneHua OHMUGWOMUNOYCMOUYUBbIX Inmepobanmepul Aloxnan Cosewarna BOS Bunyuicto ustatemersom «Meanuiiia> no mopyyenmio Mu- HucTeperRa 31paRooxpancuHa Coiosa Conetckux Comnasuern- ueckux Pecuy6anx, Koropomy BO3 swepia Bumyek Zauioro H3jlaHHA Ha pyCcKOM ALIKE BeemupHas opraHnzauva 3apaBooxpaHeHVia Cepua TexHiyueckux A0KNapoB 624 ® Bcemupxar opraHn3auua 3apaBooxpaHenua , Kexesa, 1980© Beempraz oprasnsanna sapavooxparenua, 1980 Ha nyGankanun Beemupuofi oprannsaunn anpasooxpanenus pacnpocrpa- HmuoTcA MOnOxeHHA NpOToKoAa Ne 2 Beempuoi KouBexunn 06 oxpate aBtop- CKHX mpap. Basiaenust oO paspewenMa Ha mepenevatxy want nepesom ny6aNKa- unit BO3 vacrauwo wan in foto caeayer HanpaBiath B Onsen ny6anKaunit n nepesoxios Beemupnoii oprauusauun snpavooxparienus. )Kenewa, Iluefina- pus, Beeupias oprailiizauia sapanooxpaenna OxoTHO yaoBjeTBOpseT TaKiIe mpoceOst. Hanmenovaima, ncnoasyeMbie 8 HacTosmem aqaHuH, 1 mpHBoAUMBE B HeM MatepHadst He aMpaaKaIoT Mute Cexpetapuata Beetmpuoit opraunsa- NUH 32paBooxpaneuHA 06 lopHauYecKOM cTalyce KaKOi-260 cTpaHbl, Teppx- ‘Topi, Topoga itn paiiona, Hx MpapitrexbcTBe HIM APyTOM Opratte BaaCTH Halt © ix rocygaperRenmtinx rpannuax. Yuowmianne weKoTOpHX KOMMAHH HTH MPOYKUMH OTAeAbHBIX HBroTOBH- reaeli ue osHasaer, vro Beemipiaa opranmsayua 3qpabooxpanenua otaaet HM Mpenmoutenue mo cpaBHeHMio C ApyruMu, He YNOMAHYTLIMH B TeKcTC. Tlarentonauune HalMeHOBaHHa BLIeAmIOTCR HaqasbHbM Mpomacuumn GyK- pam. 039(01)—80 039(01)—80 B3—80. 4102000000COJ.EP)KAHHE 1. Beegenne 2. OGpacuente HeKoropwx Tepunnos . . . 2.1 Yeroiivnsocrs x anTH6uoraKam in vitro eof elt al 22 Ecrecrsennaa u mpwoOperenuaa ycrofuusocrs . 2.3 Broxumusieckne m reaeTineckue MexanuaMM ycroituBocTH 24 Coxpamenun 4 xepunumumn . . . 3. Cospemennoe coctosune aTuGuoruxoycroiuupocty snTepoGakrepuit 3.1 Yactora oGuapyxenust antruOuoTuKoycrolyuBocrn y axtepin, MuGuNupyIoMNX NeNOBeKA uM XKUBOTHBX . : 3.2 Sminemnveckne nembiunKH, abIgRaHHBIe yeTolivuBBINH K steKapeT- BeHHSIM Npenapatam sHTepoGaxTepHAMit 4. Paxrop pesxerentnoera, pacnpoctpannemutlt sitepoSaxrepuamn 5. axropu, o6ycaonauBaiouUle MOABeHHe mM pacnpoctpaneHHe yc- Toitimoctn K auTHOHOTHKaM State 5.1 Venoamsonanue aatu6uoruxon B MegnuuucKolt mpaxruxe : 5.2 Venomsonanne anTaGnoraxon 8 netepuxapHoll mpakruKe M XHBOTHOBOACTRe ot 5.3 Pon wnueBbX MpomyKTOB B pacnpocTpaxeHUH aNTHGHOTHKO- yeroitunaux Gaxrepui 2... 54 Pos» crouax m moepxHocTHEx Bom 6. Kourpoab pacnpocrpanenus autu6uoruKoycrofiumsnx Gaxrepnit 6.1 OGocnonanne Heo6xomuMmocrH snMAcMHONOrHYecKOrO HaRsopa 6.2 Burogn ¢ TouKH speHsist SApasooxpanenlst u 9KOHOMHKH 6.3 Onuzemuonoruseckui waxsop m KoRTpos» pacnpoctpanenns aNTHOnOTHKoycToiunenx GakrepH y venosexa. .. 6.4 Snuxemnoxoruueckuit Hansop m KOHTpom Pacnpocrpanennn at- THOHOTHKOYcTOAMHBEX GCaKTepuit y %KHBOTHNX : 6.5 Suuemsosornveckni Hanaop M KoHTpom pacnpoctpanerns at. THOnoTHxoycroNMBHX Gakrepult B OKpyxaioteli cpene . 6.6 Konrposs 3a SIHeMMNeCKHMH BCIBIUIKaMH . 7, JaGopatopune Metoab usyseHa ycroiaunocra saTepoGaktepnit 7.1 Metoum ompenesenua uypcrBuTeabuocrH Gaxrepuit in vitro 72 TIpapona m uaenTabuKanna masMuq pesucrentHocrn 73 O76op ¥ wecnenonaHHe mpo6 crounEIX mM noBepxHOCTHBX Box 8, Tloaysenue m o6pa6otka aaHRBX =... 9, Opranusanun nporpaMMel atujemMomornueckoro Haxgopa 9.1 Tpo6xems snuzemnonoriiteckoro axzopa 82 yerofiumnoets10 K aHTHOHOTHKaM =... : Peet 9.2 Ucnoapsonanue uncopmanun, TomywenHon B xome ocyitectaze- HUA MporpaMMb! suMAeMMOmOrMYecKoro Mamsopa . . 9.3 TpeGonauua x opradusannH smujeMuomoruueckKoro Haysopa 3a JeKaperBenow yerowuunoctb® . ek ew 2-556 22 22 23 24 25 26 26 26 7 28 2 29 30 34 35 36 38 3810. Pesiome 2. 11. Pexomengauun 2. Baarogapyocrs . Tpmaoxenue 1. Tpamewanus x amerpyxn | 10 pmwenenno AHCKOBOTO meToma ; Tipuaoxenne 2. JlaGopatopriie Meronw Busbsenus nepeaain dbaxropa PesuctentHoct (R-dakTopa) u naaamuguui anaaus Tipuaoxenne 3. Mero o7Gopa npo6 u oxpyxkaromiek cpems 4 WX He- caenopalua Ha HasusMe yCTOAMMBLX MHKpooprannaMoB 42 45 46, 48 53. 58COBEUJAHKHE BO3 MO SMMAEMMONOFMYECKOMY HAA3O0PY B MPO@MNAKTHKE K KOHTPONE PACIPOCTPAHEHMA AHTHBMOTHKOYCTOMYMBLIX SHTEPOBAKTEPHA JKeneea, 18—24 oxrabpa 1977 2. Yaacraunu coaewyanun: Mpop. E. S. Anderson, aupextop, Corpyannuaioummi xeurp BOS no dbaro- THMMpoBaHINO M oMpenereHHIO ycroiuIocTH suTepoGaktepuit, CnpaBod- Had daGopatopus no KKWesHbiM andexunam, Llextpassuas’ aa6oparo- Pia OGmecrBexHioro sapanooxpanenua, Jlonnon, Auraua (npedcedarea») Tp A. Balows, anpexrop, Corpyaunuaiommit Hayano-HecaeqopaTeabcKntit it cnpazounnti uextp BO3 no Ouonornueckum npomyxtam (anTHGHoTHKH H cyOcraHUMH, OOuanaioUlHe anTHOHOTHYeCKHM jelicTBHeM), oTAeNeHHe Gaktepnoaorun, JIaGopatoputi orgea, Henrp no Gops6e ¢ GoaesHamn, Araanta, urrar JLKkopiokus, CIA Tipo. Y. A. Chabert, pykonognress, orgen meamnuncxof 6axrepnozornu, Mctutyt Macrepa, Mapu, pannus J-p O. Grados, pykosoantens, Cnpapowtas aa6opatopus mo _ Kuttiewnim mbexuusn, Hauonanbiole unerutytit sipasooxpaneuns, Jama, Tepy TIpo. J. Jeliaszewicz, Gakrepuonornuecknit orgen, Haunonaabuni uucra- TYT rurHenbi, Bapuiasa, Moasma (doxaaduux) TIpop. O. Ogunbi, kadbeapa muKpoGHosoruH wm napasnTonorun, Meauuun- ckHi Konaen2xK, JIaroccxuit yuuepcnter, Harepua T-p M. Ohashi, crapumit Gaxrepuoaor, maxpo6uosornueckut ornex, To- POACKAN HayNHO-HeceXOBATeTbCKaA Ta6opatopus OGULeCTBEHHOFO Bapa- Booxpanenus, ToKHo, ANOHHA Mpop. K. B. Sharma, xadeapa muKpoGuosoru, Meanunucknii Komen eam Xapanur, Jeau, Huwna (samecrureas npedcedarean) Tipo. T. Bexwmuna, Kaceapa muxpo6uosorun, Lextpamputii uacturyr yeosepuiexctsonanna spaveii, Mocxna, CCCP Ha6arodareae: Tipo. E. Bulling, Corpyaumatomuit vaysio-uceaeaosarenbckut « yaeGuinit uentp AO/BO3 ‘mo ruruene nuiessix mpoaystos, Hncrutyr Bete puHapun PoGepra cox Ocreptara, Denepambxce 610po obulecTBeHHoro sapapooxpaneina, Bepann (Sanaanei) Cexperapuar: cp D. Barua, mexmmmnexuf cneunasmer, cexyua BOS Gakrepuanbunx u nenepuueckux Gonesneli, Keuesa, Usefinapun (cexperaps) Lp B. Cvjetanovié, raanaui meamumnckuit cneunanner, GakrepHanoubie 1 BeHepHueckne Hndexunn, BOS, JKexepa, [neiiuapua A-p E. J. Gangarosa, samectitens gupextopa, oTmenenne Gakreprambinx Goaesnel, oraen suusemnonornn, Llentp 10 Gopp6e c Gonestiamn, AT- santa, uirar ToKopaaKna, CLA (epemennout xoncyssrant) U-p R. Martinez Silva, xoricyasrant no aa6opatopomy xeay B oOmect- BeuHOM sipanooxpancrun, Pernonatuce Gopo BOS xan crpan Ane- puxu / Tlaxamepikanckoe caxutapnoe Grpo, Bammurtox, oKpyr Ko- aym6us, CIA J-p M. Radovanovié, pernonaapuutit xoucyaptaur (unexuuounsie Gones- uu), Esponeiicxoe pernoxansioe 610po BO3, Koneuraren, Jams o* 5U-p A. H. Wahba, peraonaapunii xoncyssraxt mo xaGopaTopubim cayx6aM sapabooxpanenust, Expouefickoe pernouastbHoe 6:opo BO3, Koneiraren, Tanna Tep K. Western, pyxouoantea orena mmexunonnsix Coaesneit, Perno- Hasbiioe Giopo BOS nx crpan Amepuxa / Tlanamepuxauckoe canurap- noe 61opo, Bawanrron, oxpyr KoaymOus, CLA Mpop. J. D. Williams, xadeapa meamuincko® muxpo6uonornu, Meaunuu- cKHi Korea mp JIououcxoi Goabuune, JlongoucKHA yaunepcuTet (apemennouti xoncyaoranr) Ip A. Zahra, ornex unhexunonnsix 6oxesnet, BOS, Kenesa, UselinapusSNMAEMMOJIOrHYECKHHM HA30P B MPO®HJIAKTHKE HW KOHTPOJIE PACIIPOCTPAHEHHA AHTUBHOTHKOYCTOM YABbIX SHTEPOBAKTEPHM Tlokaay, cosenjanua BOS Cosemjanue BO3 no onmHgemMHosorHyecKoMy Haq30py B Mpo- cbuaakTHKe HM KOHTpose pacnpoctpaHenna auTH6MoTHKoycToHaH- BbIX 9HTepoGaKTepHit mpoxozumo B Kenese 18—24 oxra6pa 1977 r. Ilo nopyyenmio TenepaabHoro upeKTopa copemlanne orkppit -p A. Zahra. 1. BBEMEHHE BeemupHas opranusaiua 3qpaBooxpaneHHA MpoaBseT Gomb- moi wHTepec K Mpob6AeMe aHTHOMOTHKOYCTOMUMBOCTH MHUKPO6OB. B 1960 r. 6biu1a mpennpHHnata mepBad MonbiTKa cTanapTHsalHHn Aa6opaTOPHLIX MECTOOB OLpeweCHHA YYBCTBATebHOCTH MHKPO- opranusmos [/], ofHako TpeGoBanHA K ONperecHHIO YyBCTBH- TeJIbHOCTH MAKPOOPraHH3MOB K aHTHOHOTHKaM C HCIOAb3OBaHHeM MeTogwa guckos (Tpe6opanuaA Kk OMOmorMyecKHM MpenapaTaM, Ne 26) 6piau chopmyaupoBann Komutetom skcneptos BOS mo cTaHapTHsauMH OuOAOrHYeCKHX MpemapaToB TombKO B 1976 r. [2]. B To Ke BpemMa acieKTbI OOulecTBeHHOFO 3paBOOXxpaHeHHA, CBAZAHHBIC C IPHCYTCTBHEM aHTHOWOTHKOB B MHULeBbIX MpOLyKTaX W OKpy«alollel cpexe, ABHAWCh MpeMeTOM H3y4eHHA TPeX KO- MuTeTOB 9KcHepToB BO3 [3—5] a zByx conelanHi, opranu30BaH- HbIx Epponefickum pervonasbubim 61opo BO31?. B 1974 r. B Arnaute, utat J2xopyxxua, CIUA, Onin cosnzan CorpyaHnyaw- ujwit Hay4Ho-nccreqoOBaTesbCKH A cHpaBounEi ueHTp BOS 110 OuosorMuecKHM MpomyKTaM (aHTHONOTHKH H cy6cTaHunH, o67a- Raloulve auTHOHOTHNeCKHM gelicrBHem), a B 1975 r. mpH Cnpa- 1 WHO Regional Office for Europe. The public health aspects of anti- bioties in feedstuffs. Report on a Working Group, Bremen, I—5 October 1973, Copenhagen, 1974 [HeonyGnuxonanseit goxymexr EURO 3604 (2)]. 2WHO Regional Office for Europe. The public health aspects of ant otic-resistant Bacteria in the environment. Report on a Consultation Mee- ting. Brussels, 9—12 December, 1975, Copenhagen, 1976, (ueony6anxonanxnit nokysent ICP/FSP 002). 3—556, 7