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Prevalence of Depression among Undergraduate Pharmacy Students in


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ISSN 0975-2366
DOI:https://doi.org/10.31838/ijpr/2020.12.03.282
Research Article

Prevalence of Depression among Undergraduate


Pharmacy Students in Malaysia
NAJLAA SIHAM MOHAMED YUSOF1, ZAINOL AKBAR ZAINAL2*, HASNIZA ZAMAN HURI3, SABRINA
ANNE JACOB4, MUHAMMAD NAJIB MOHAMAD ALWI5, YAHAYA HASSAN6, ROSNANI HASHIM7,
IZYAN A. WAHAB8, AINA YAZRIN ALI NASIRUDDIN9, NURUL ASHIKIN JAMLUDIN10, AMELAH
MOHAMMED ABDUL QADER11, SHAIRYZAH AHMAD HISHAM12, NURDIANA JAMIL13, CHIN SHIN
CHEE14, LIANA NAZURAH GHAZALI15
1
Faculty of Pharmacy, University of Cyberjaya, Cyberjaya, Selangor, Malaysia.
2
Faculty of Medicine, University of Cyberjaya, Cyberjaya, Selangor, Malaysia.
3
Department of Pharmacy, Faculty of Medicine, University of Malaya Kuala Lumpur, Malaysia.
4
University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United
Kingdom.
5
Faculty of Medicine, Management and Science University, Shah Alam, Selangor, Malaysia.
6
Faculty of Pharmacy, Management and Science University, Shah Alam, Selangor, Malaysia.
*Corresponding Author
Email ID: zainol.akbar@cyberjaya.edu.my
Received: 10.03.20, Revised: 16.04.20, Accepted: 24.05.20

ABSTRACT
This study aimed to determine prevalence of depression among undergraduate pharmacy students in Malaysia
and its factors. A cross-sectional web-based questionnaire was distributed through email and social media
platforms to 19 institutions offering Bachelor of Pharmacy (Hons.) in Malaysia. Students were assessed using
Depression Anxiety Stress Scale-42 (DASS-42). A total of 610 pharmacy students participated in this study
resulted in a response rate of 20.3%. Pearson’s Chi square test was used to determine the association between
different demographic groups. One-way ANOVA and independent T-test were used to evaluate the difference in
depression scores between groups. Based on the depression scores, this study found that 47.4% (n=289) were
having depression of different severity. Most of the students presented with moderate depression (18.9%, n=115)
followed by mild (14.1%, n=86), severe (7.7%, n=47) and a few students were found to have very severe
depression (6.7%, n=41). Compared to students who did not have depression, students who smoke, have
separated parents, with family history of mental illness, had recent loss of someone close, and with lower CGPA
were statistically significantly associated with depression. This study concluded that depression is highly
prevalent among pharmacy undergraduate students in Malaysia. Strategic approaches among various
stakeholders mainly the higher education providers are urgently needed to prevent further complications of
mental health issue.
Keywords: Mental Health, Depression, Pharmacy Students, university, Malaysia.

INTRODUCTION Development Goals (SDG) indicators by Malaysia


Depression is an emotional and mental disorder government7.
that can cause lack of interpersonal, social and University students reported twice as much stress
occupational functioning1 which are characterized as general adult population related to academic
by low mood, fatigue and inability to enjoy life 2. performances and personal life changes8. The
Around 350 million people are suffering from prevalence of depression among university
depression with an increase of more than 18% students around the world ranged from 21% to
between 2005 and 2015 which is equivalent to 47%9,10,11,12,13,14. Studies have shown that medical
4.4% of the world’s population3. The South-East students had higher anxiety and depression cases
Asia region has the highest percentage of compared to students from other fields15. However,
depression cases. The 2015 National Health and a recent study among pharmacy students reported
Morbidity Survey (NHMS) reported that the high level of stress leading to low quality of life16.
prevalence of mental health problems among Depression can be influenced by many factors
adults 16 years and above in Malaysia was as including socioeconomic status17, place of study1,
high as 29.2%4. Mental health has now been financial constraint18 and also relationship
given a priority because of significant shift of instability12. Endless exam19 and course work20,
increasing mental health issues among young and lack of leisure time12 may increase the
adulthood5,6. It is also now being used as one of incidence of depression among pharmacy
the important mental haelth Sustainable students. In Pakistan, pharmacy students in private
universities (53.3%) have higher prevalence of

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Students in Malaysia

depression compared to public universities history of mental illness, recent loss of someone
(49.7%)21. close within the past 1 year, presence of medical
However, depression among students are widely condition, current use of medication, opinions on
undiagnosed and untreated due to stigma, fear of likely cause of depression and ways to overcome
misunderstanding22 as well as inadequate mental depression were collected as well. The students
health resources23. There are limited studies about were asked to rate the depression symptoms they
depression among pharmacy students in Malaysia experienced over the past 1 week.
and its association with student-related factors Each item was scored on a 4-point Likert scale (0
including academic achievement, living = Did not apply to me at all, 1 = Applied to me to
environment and family factors. The primary some degree, or some of the time, 2 = Applied to
objective of this study was to determine the me to a considerable degree, or a good part of
prevalence of depression among undergraduate time, and 3 = Applied to me very much, or most
pharmacy students in Malaysia and its factors. of the time). Based on the guidelines, scores of 0
to 9 were considered ‘normal’, 10 – 13 were
MATERIAL AND METHOD considered mild depression, 14 – 20 were
This cross-sectional study was conducted using considered moderate depression, 21 – 27 were
web-based questionnaire from August 2018 to considered severe depression and 28 and above
September 2018. Students were sampled via were considered very severe deprssion26.
purposive sampling method. Students were All the data collected from the questionnaire were
included if they consented to participate and were summarized using Microsoft Excel and analyzed
currently active undergraduate pharmacy students using Statistical Packaged for Social Sciences (SPSS)
studying at any of the 19 institutions offering version 23.0 for Windows. The statistical
Bachelor of Pharmacy (Hons.) in Malaysia during significance was set at p < 0.05. All descriptive
the period of this study. Students with known data were expressed as percentage. Pearson’s Chi
history of clinical depression and who did not square and Fisher’s Exact test were used to
complete the questionnaires were excluded from analyze the association of the tested demographic
analyses. Based on a database acquired from the characteristics and the prevalence of depression
institutions, there were approximately 3,000 active among undergraduate pharmacy students in
undergraduate pharmacy students from the 19 Malaysia. The mean depression score was
institutions offering Bachelor of Pharmacy (Hons.) compared between various group of the tested
in Malaysia. variables using one-way ANOVA and independent
Representatives from each institution were T-test.
approached via email and social media platforms. All aspects of the study protocol, including the
The representatives were informed about the ethics involved, were reviewed and approved by
research and agreed to share the link to the the CUCMS Research Ethics Review Committee
questionnaires to their colleagues. The link was (CRERC) (CUCMS/CRERC/ER/109). All data
also posted on the Malaysian Student Pharmacy collected were kept private and confidential and
Association (MyPSA) official Facebook® page. were only accessible by the principal researcher.
Reminder emails were sent every 2 weeks between
August to September 2018 to increase the RESULTS
response rate. A total of 610 pharmacy students participated in
The web-based questionnaire consisted of 22 this study resulted in a response rate of 20.3% (n=
demographic questions and 14 610/3000). The distribution of students according
depression-related questions which were extracted to their demographic is as presented in Table 1.
from the original 42-item Depression Anxiety Majority of the participated pharmacy students
Stress Scale (DASS-42). The questionnaire used were age ranged between 20 and 24 years old
was in English language and has been adopted (n=512, 84%), do not consumed alcohol (n=571,
and adapted from previous study done by 93%), do not smoke (n=602, 99%) nor use
Shamsuddin et al., (2013); Vignola & Tucci (2014) recreational drugs (n=604, 99%), living at
and Yusoff et al., (2013)12,24,25. Demographic data students’ hostels (n=318, 52%), and not married
collected includes age, gender, alcohol (n=572, 94%). The participated students were
consumption, cigarette smoking or vaping habit, mostly from public universities (n=367, 60%), had
recreational drug usage, ethnicity, religion, place no scholarship for the pharmacy degree program
of residence, marital status, current year of study, (n=436, 72%), had good CGPA (n=306, 50%)
institution, scholarship status, CGPA, and family and one-third family monthly income between
monthly income. Other variables such as RM2000 and RM5000.
pharmacy degree as first choice to study, family

2034| International Journal of Pharmaceutical Research | Jul- Sep 2020 | Vol 12 | Issue 3
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Students in Malaysia

Table 1: Demographic Profile of Participated Undergraduate Pharmacy Students (n = 610)

Demographic data Frequency Percentage (%)


Age 18 – 20 years old 78 12.8
20 – 24 years old 512 83.9
25 – 29 years old 20 3.3
Gender Male 98 16.1
Female 512 83.9
Ethnicity Malay 500 82.0
Chinese 61 10.0
Indian 36 5.9
Others 13 2.1
Religion Islam 511 83.8
Buddha 48 7.9
Hindu 29 4.8
Christian 14 2.3
Others 8 1.3
Alcohol consumption Yes 39 6.4
No 571 93.6
Cigarette smoking or vape Yes 8 1.3
No 602 98.7
Recreational drug usage Social user 4 0.7
Regular user 2 0.3
No 604 99.0
Current place of residence Home 152 24.9
Hostel 318 52.1
Rental house 139 22.8
outside campus
Others 1 0.2
Marital status Single 572 93.8
Married 2 0.3
Divorced 1 0.2
In a serious 35 5.7
relationship
Current year of study Year 1 127 20.8
Year 2 149 24.4
Year 3 143 23.4
Year 4 191 31.3
Current institution Public 367 60.2
Private 243 39.8
Scholarship Yes 174 28.5
No 436 71.5
CGPA 2.00 – 2.99 95 15.6
3.00 – 3.49 306 50.2
3.50 – 4.0 209 34.3
Family monthly income < RM 2,000 132 21.6
RM 2,001 – RM 182 29.8
5,000
RM 5,001 – RM 121 19.8
8,000
> RM 8,000 175 28.7

Among the 610 students, nearly half of them (n= 18.9% had moderate depression, 7.7% had
289, 47.4%) was found to have depression. Of severe depression and 6.7% had very severe
these, 14.1% of the students had mild depression, depression. Based on the tested demographic

2035| International Journal of Pharmaceutical Research | Jul- Sep 2020 | Vol 12 | Issue 3
Najlaa Siham Mohamed Yusof et al / Prevalence of Depression among Undergraduate Pharmacy
Students in Malaysia

characteristics of participating pharmacy students, more students not depressed among those who
smoking status, parents’ marital status, pharmacy did not smoke, consistent with significant higher
degree as first choice degree, CGPA status, family mean depression score in students who smoke
history of mental health, comorbidities and recent cigarettes or vape (18.50, SD= ±10.24), p <
loss of someone close were found significantly 0.05) (Table 3).
associated with depression (Table 2). There were
Table 2: Characteristics of Pharmacy Students based on DAS-42 Score (n = 610)
Demographic Characteristics Depression p
No Yes value
Age < 20 years old 50 28 0.08 a
(64.1%) (35.9%)
20 – 24 years old 262 250
(51.2%) (48.8%)
25 – 29 years old 9 11
(45.0%) (55.0%)
Gender Male 56 42 0.33 a
(57.1%) (42.9%)
Female 265 247
(51.8%) (48.2%)
Alcohol consumption Yes 17 22 0.24 a
(43.6%) (56.4%)
No 304 267
(53.2%) (46.8%)
Cigarette smoking or vape Yes 1 7 0.03 b
(12.5%) (87.5%)
No 320 282
(53.2%) (46.8%)
Recreational drug usage Yes 1 5 0.11 b
(16.7%) (83.3%)
No 320 284
(53.0%) (47.0%)
Ethnicity Malay 257 243 0.20 a
(51.4%) (48.6%)
Non-Malay 64 46
(58.2%) (41.8%)
Religion Muslim 261 250 0.08 a
(51.1%) (48.9%)
Non-Muslim 60 39
(60.6%) (39.4%)
Place of residence Hostel 173 145 0.36 a
(54.4%) (45.6%)
Non-hostel 148 144
(50.7%) (49.3%)
Marital status Single 305 267 0.18 a
(53.3%) (46.7%)
Non-single 16 22
(42.1%) (57.9%)
Parents’ marital status Still together 292 244 0.01 a
(54.5%) (45.5%)
Separated/ divorced/ 29 45
widowed (39.2%) (60.8%)
Pharmacy degree as first choice to study Yes 217 168 0.02 a
(56.4%) (43.6%)
No 104 121
(46.2%) (53.8%)
Current year of study Year 1 76 51 0.32 a
(59.8%) (40.2%)
Year 2 75 74

2036| International Journal of Pharmaceutical Research | Jul- Sep 2020 | Vol 12 | Issue 3
Najlaa Siham Mohamed Yusof et al / Prevalence of Depression among Undergraduate Pharmacy
Students in Malaysia

(50.3%) (49.7%)
Year 3 71 72
(49.7%) (50.3%)
Year 4 99 92
(51.8%) (48.2%)
Current institution Public 195 172 0.80 a
(53.1%) (46.9%)
Private 126 117
(51.9%) (48.1%)
Scholarship Yes 90 84 0.78 a
(51.7%) (48.3%)
No 231 205
(53.0%) (47.0%)
CGPA 2.00 – 2.99 40 55 0.01 a
(42.1%) (57.9%)
3.00 – 3.49 156 150
(51.0%) (49.0%)
3.50 – 4.00 125 84
(59.8%) (40.2%)
Family monthly income < RM5,000 157 157 0.18 a
(50.0%) (50.0%)
> RM5,000 164 132
(55.4%) (44.6%)
Family history of mental illness Yes 21 36 0.01 a
(36.8%) (63.2%)
No 300 253
(54.2%) (45.8%)
Recent loss of someone close within the Yes 72 88 0.03 a
past 1 year (45.0%) (55.0%)
No 249 201
(55.3%) (44.7%)
Medical condition Yes 61 85 0.003
a
(41.8%) (58.2%)
No 260 204
(56.0%) (44.0%)
a
Pearson’s Chi square test
b
Fisher’s Exact test
Table 3: Difference in mean depression score based on DAS-42 between groups (n=610)
Demographic characteristics Mean Score p-value
(±SD)
b
Age 18 – 20 years old 8.58 (±7.52) 0.05
20 – 24 years old 11.20 (±9.39)
25 – 29 years old 12.50 (±10.18)
Gender Male 10.37 (±9.46) 0.54 a
Female 11.01 (±9.19)
Alcohol consumption Yes 11.26 (±8.83) 0.80 a
No 10.88 (±9.27)
a
Smoking cigarettes or vape Yes 18.50 (±10.24) 0.05
No 10.80 (±9.18)
Recreational drug usage Social user 17.75 (±14.08) 0.11b
Regular user 20.50 (±14.85)
No 10.83 (±9.17)
b
Ethnicity Malay 11.22 (±9.30) 0.003
Chinese 6.92 (±6.70)
Indian 12.19 (±10.74)

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Students in Malaysia

Others 13.92 (±8.27)


b
Religion Islam 11.26 (±9.27) 0.001
Buddha 6.75 (±6.82)
Hindu 10.84 (±10.84)
Christian 5.93 (±5.51)
Others 15.63 (±9.94)
Current place of residence Home 11.28 (±8.80) 0.26 b
Hostel 10.24 (±8.64)
Rental house outside campus 11.99 (±10.83)
Others 15.00 (±0.00)
Marital status Single 10.83 (±9.25) 0.58 b
Married 10.50 (±9.20)
Divorced 2.00 (±0.00)
In a serious relationship 12.46 (±9.10)
a
Parents’ marital status Still together 10.53 (±8.98) 0.02
Separated/divorced/ 13.64 (±10.53)
widowed
a
Independent T-test
b
One-way ANOVA with post hoc analysis
Table 4
a
Pharmacy degree as students’ first choice Yes 9.90 (±8.39) 0.001
to study No 12.62 (±10.31)
Current year of study Year 1 9.54 (±8.36) 0.30 b
Year 2 11.36 (±9.45)
Year 3 11.48 (±8.70)
Year 4 11.03 (±9.95)
Current institution Public 10.51 (±8.64) 0.21 a
Private 11.50 (±10.05)
Scholarship Yes 10.60 (±9.00) 0.60 a
No 11.03 (±9.33)
b
CGPA 2.00 – 2.99 13.58 (±10.28) 0.001
3.00 – 3.49 11.27 (±9.49)
3.50 – 4.00 9.15 (±7.95)
Family monthly income < RM2,000 11.35 (±9.31) 0.36 b
RM2,001 – 11.22 (±8.97)
RM5,000
RM5,001 – 9.56 (±8.82)
RM8,000
> RM8,000 11.17 (±9.70)
a
Family history of mental illness Yes 15.33 (±10.45) 0.001
No 10.45 (±8.98)
a
Recent loss of someone close within the Yes 12.53 (±9.68) 0.01
past 1 year No 10.33 (±9.01)
a
Medical condition Yes 10.16 (±8.88) 0.001
No 13.26 (±9.94)
On medication Yes 13.03 (±10.24) 0.06 a
No 10.61 (±9.05)
a
Independent T-test
b
One-way ANOVA with post hoc analysis

There was also a significant higher number of not was found significantly higher among those with
depressed students with still together parents pharmacy degree not their first choice degree
supported by higher mean depression score (12.62, SD= ±10.24), p < 0.05). Consistent with
(13.64 (±10.53), p < 0.05) in students with pool of students who are not depressed with
divorced parents. Pharmacy students were also not higher CGPA (Table 2), pharmacy students with
depressed among those who selected pharmacy lower CGPA (2.00 – 2.99) had higher mean
as their first choice degree. Mean depression score depression (13.58, SD= ±10.28) compared to

2038| International Journal of Pharmaceutical Research | Jul- Sep 2020 | Vol 12 | Issue 3
Najlaa Siham Mohamed Yusof et al / Prevalence of Depression among Undergraduate Pharmacy
Students in Malaysia

high achiever students with CGPA 3.50 – 4.00 Another interesting finding related to depression in
(9.15, SD= ±10.28) (Table 3). Similar to higher this study is the choice and decision to undertake a
pool students’ numbers who were not depressed pharmacy program as their future career. In this
among those with no family history of mental study, there was a statistically significant
illnesses, no recent loss of someone close and with association between pharmacy degree as students’
no comorbidities. These associations were first choice to study and depression. Students who
supported with significantly higher mean had chosen pharmacy degree as their first choice
depression score for pharmacy students with were less depress and had lower mean depression
family members having mental health problems score in contrast to students who did not. Until now,
(15.33, SD= ±10.45), had recent loss (12.53, there is no specific study that investigate the
SD= ±9.68) and students with medical conditions association between the career path choice and
(13.03, SD= ±10.24). depression in pharmacy students. A study in
Meanwhile, there were statistically significant Jordan among nursing students found that
differences in mean depression score between age students who chose nursing as their career
groups, ethnicities, and religions(p < 0.05) (Table because of family decisions were significantly
3). The mean depression score among the more depressed than those who did not33. Another
students between 25 and 29 years of age is higher study undertaken for medical students found that
(12.50, SD= ±10.18) compared to other age students who were pressured to become doctors
group. Across different ethnicities, the mean and expected to gain much money were both
depression score for Bumiputera living in Sabah more anxious and more depressed (p < 0.05)34.
and Sarawak was reported to be the highest Both studies show that when the program of
(13.92, SD= ±8.27) followed by Malay (11.22, choice was not from the students’ interest, there
SD= ±9.30), Chinese (6.92, SD= ±6.7) and might be some complications affecting students’
Indian (12.19, SD= ±10.74) living in Peninsular mental health state.
Malaysia. Among different religions, students of While becoming a student in university can be full
other religiosity were found to score the highest of new experiences and marks an exciting journey
mean depression score compared to Islam, towards a career, satisfaction on decision making
Buddha, Hindu and Christian religions. of the intended degree in addition to subsequent
smooth transition from secondary school to
DISCUSSION university increases the chances of students’
This study provides a snapshot of current academic achievement and persistence. Educators
depression prevalence among Malaysian need to realize that the first-year of university life is
undergraduate pharmacy students. Several tested prudent to expose new students having various
variables such as smoking, academic of choice backgrounds and whether or not it is their first
and achievement, and family environment may choice degree to a very supportive, motivational
play significant roles in the depression and clear educational goals. Workplace learning,
development. These variables are potentially experiential learning, inter-professional and
preventive in nature and efforts to identify and team-based learning exposed as early as in the
implementing depression prevention program are first-year university students can increase students’
highly desirable to avoid future harm. Smoking retention and satisfaction towards degree
was generally more prevalent in mental illnesses program35.
population compared to general population27. The design and delivery of pharmacy curriculum
Similar finding by Lyvers, Thorberg, Dobie, & and its assessment methods should be carefully
Reginald (2008) reported that smokers had strategized to cater for students with high potential
significantly higher level of depression score to get depressed. Depression among pharmacy
compared to non-smokers28. There are studies student was partly caused by academic stressors
found that mental health problems can be namely frequent examinations, quizzes and
improved with smoking abstinence. In Czeh assignments36. The present findings where lower
Republic study involving 3775 depression patients CGPA students had higher mean depression score
enrolling into smoking cessation clinic had is consistent with a local study conducted at
significant improvement of depression after 1-year University of Malaya involving 273 pharmacy
follow-up29. Smoke-free policies and campaigns students which found academic performance was
can be successfully conducted at universities in correlated with stress37. The most frequently
some European and Asian countries and had reported stress was related to academic matters.
positive impact on behaviour30. Regular physical Depressed students commonly showed reduced
activities had been associated with better mental concentration, loss of interest and loss of energy
health which can be used by universities and eventually affect their academic
concurrently with smoke-free campaign31,32. performances38. Appropriate remediation
strategies can be developed and implemented

2039| International Journal of Pharmaceutical Research | Jul- Sep 2020 | Vol 12 | Issue 3
Najlaa Siham Mohamed Yusof et al / Prevalence of Depression among Undergraduate Pharmacy
Students in Malaysia

targeting to students who are at risk or already limitation was that there was no focus on any
known with mental health issues to help them interventions that could benefit the students who
improve academic functioning39. were having depression.
Family factors which include history of mental
illness and separated parents are prone to get CONCLUSION
depression than students with no family history Generally, the prevalence of depression among
and parents who remained married. Family history Malaysia undergraduate pharmacy students was
remains the single stronger predictor of mental high as nearly half of the students were found to
illnesses where offspring of parents with major have certain degree of depression. This study
depressive disorder have one-in-three risk highlights that depression was associated smoking
developing severe mental illness themselves40. status, parents’ marital status, pharmacy degree
Other studies show children that going through as first choice degree and CGPA. Other
parental divorce can give negative impact on characteristics such as age, ethnicity, religion,
child’s mental health41,42. In addition, students with family history of mental illness, recent loss of
medical condition were found to have depression someone close in the past 1 year and having
compared to students who did not have any known medical condition have higher mean
medical condition. Early preventive program depression score. Various parties including
efforts by the university could be introduced to policymakers, higher education providers, and
address a wide variety of concerns from academic parents could come together and formulate
to interpersonal relationship in order to detect and appropriate preventative strategies to overcome
wane early signs of depressive symptoms among this issue among future pharmacists and
at risk students. The preventive programs can eventually ensure continuous quality of healthcare
include stress management course to delivery to the Malaysian population.
body-mind-stress-reduction (BMSR) techniques
such as yoga, breath work, meditation and ACKNOWLEDGEMENT
mindfulness43. This study would like to acknowledge all
This study also showed there were significant representatives and pharmacy students from the
depression among the races and religion groups 19 institutions who willingly participated in this
of Malaysian undergraduate pharmacy students. study.
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Students in Malaysia

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