Spiractin for transgender treatment

Spiractin tablets 100mg contain spironolactone, which is primarily used as a diuretic, to reduce fluid
retention in conditions such as congestive heart failure, hypertension (high blood pressure), liver
cirrhosis and kidney disease. Spironolactone in Spiractin tablets 100mg also acts as an anti-androgen
by binding to the androgen receptor and competing with dihydrotestosterone (DHT), the active
metabolite of testosterone, which promotes male characteristics, thereby blocking the action of DHT.
Using an anti-androgen like spironolactone (usually in high doses of 200–400 mg per day) allows the
amount of oestrogen administered for feminising hormone therapy to be reduced while optimising
the hormone regime needed to stimulate breast development, feminisation of skin, and female fat
distribution.