Original Article Does anemia affects cognitive functions in neurologically intact adult patients: Two year cross sectional study at rural tertiary care hospital Sachin Agrawal’, Sunil Kumar’, Vaibhav Ingole', Sourya Acharya’, Anil Wanjari’, Shilpa Bawankule', Nitin Raisinghani' ‘Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science (Deemed to be University), Sawang! (Meghe), Wardia, Maharashtra, India Apsrracr Background: The anemia not only negatively affects physical function but also the cognition, mood, and quality of life in adult patients due to hypoxic condition as per its severity. This study has been planned to investigate te eross section association of anemia with cognitive function in neurologically intact patients. Methods: In this stud, a total 200 subjects were enrolled out of which 100 were cases and 100 age and sex matched controls. Min: mental status examination (MMSE) and short portable mental status questionnaire (SPNSQ) scales were used fo assess cognition in all the subjects. Results: This study showed that there was a significant correlation between the anemia and ‘the cognitive skis in the neurologically intact patients. Conclusion: The cognitive Functions were strongly related to hemoglobin levels as seen by low MMSE score and higher SPMSO error in those wth low hemoglobin levels compared with those with higher hemoglobin levels, Keywords: Adult, anemia, cognition, neurologically intact Relevance to the practice less than 13 g/dL. in men" Aa estimated tra billioa of the + Anemia is a widespread disorder ia the community and it i strongly sssocinted with poor cognitive performance isespective of etiology of anemia + Asmostof the patients of anemia had cognitive impairment, all ‘hepatients of anemia should be screened tor cognitive frctions + Enily detection and prompt treatment may help to seduce the effect of anemia on cognition, Introduction Anemia s defined according to World Health Organization (WHO) ‘as hemoglobin concentration less than [2.g/40 aa 125 o2t 218 oF 00 700 Tul 10 299 136 013 262 37 1.00 700 Journal of Famy Modes and Prnexy Cane Volume 8 : eve 9 Soptomber 2010‘Agrawal, etal: Does anemia affects cognitive functions in neurologically intact adult patients? Table 6: Cognitive impairment in relation to severity of anemia Anemia Mild 211 Moderate Severe <3 (08) §10.9(0=33) _(o=18) Ne MNSE 26268347 21892201 —21a0=160 119, Scot P=0.0001,8 MesnSPMSQ 2208101 2452118 4ost117 2276, Soore P=00001, 8 males than females, They also showed meguloblastie patients had MMSE seotes below 24,14 Inoue study, there was masked difference in MMSE and SPMSQ scores in cases and control ane more number of cases had lower MMSE scoses and! more SPMSQ extors which was sigaiticant. ‘Anemit is associated with low MMSE scores and moze SPMSQ exxors. There was no gender-wise difference in cognitive Functions in eases and controls. In tis stady, we also found age was not a detrimental factor in cognitive impairment in cxses of anemia. In one studs, out of 100 cases of anemia, Inad megaloblistc anemia and was associated with significant ‘cognitive impairment Conclusion “The cognitive functions were strongly telated to hemoglobin Tevels as seen by low MMSE score and higher SPMSQ estor i those with low hemoglobin levels compaced to those with higher hemoglobin levels. All types off anemia, isrespective Of the etiology were associated with poor cognitive fmetions. Anemia, ierespective of the etiology was found to cause mild 0 ‘moderate cognitive impairment. Anemia does aot cause severe cognitive impairment, Declaration of patient consent ‘The anthots certify that they have obtained all appropriate patient consent forms. In the form the patients) lhas/bave given his/er/theic consent for his/her/theic images and other linia information to be seported inthe journal. The patients ‘understand that their names and initials will not be published and due efforts willbe made to conceal ther identity bat anonymity cannot be goasanteed, Financial support and sponsorship Nil Journal of Famy Modes and Prinexy Cane Conflicts of interest There ase no conflicts of interest 10, IL References WHO, Haemoglobin concentrations for the diagnosis fof anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization, 2011 (WHO/NMH/NHD/MINW/11.1 Available from http/Asw:who.int/\mis/indicators/ laemoglobin. [Last aecessed on 2018 Oct 18} Kassebaum NI The global ben of anemia. Hematol Oncol (Clin North Am 2016;30:247-308. \Weiskopf RB, Kramer JH, Viele M, Neumann M, Feiner JR, Watson Jef al Acute severe isovolemie aneznia impairs cognitive function and memory in humans. 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