Which of the followings best describe an agonist?

A. Having affinity for a receptor and intrinsic activity*

B. Having no affinity for a receptor and no intrinsic activity

C. It only has only affinity for the receptor

D. It only has intrinsic activity

E. It has affinity for a receptor but no intrinsic activity

When two drugs are given, the combined effect is greater than the simple algebraic sum of the action of
two drugs. Which of the given phenomenon best describes this statement?

A. Summation

B. Competitive antagonism

C. Non-competitive antagonism

D. Potentiation*

Which of the following statements best describe an antagonist?

A. Having affinity for a receptor but no intrinsic activity*

B. It only has intrinsic activity

C. It has no affinity for a receptor and no intrinsic activity

D. It has affinity for a receptor and intrinsic activity

In therapeutics many drugs are used to treat more than one diseases. Which one of the following is a
First-line anti-Parkinson drug which is also used to treat hyperprolactinemia at lower doses ?

A. Amantadine

B. Benztropinemesylate

C. Bromocriptine*
D. Levodopa

E. Selegiline

A 28 year old woman has sporadic attacks of intense anxiety with marked physical symptoms including
hyperventilation, tachycardia and sweating. She also feels depressed at times. What is the most
appropriate drug to treat her anxiety and mild depression at the same time?

A. Alprazolam*

B. Chloral hydrate

C. Diazepam

D. Phenobarbital

A 65-year old carpenter is brought to psychiatric clinic and is evaluated for schizophrenia. He also has a
history of long QT syndrome. Which of the following drug would precipitate these pre-existing
conditions, if prescribed to this patient?

A. Alprazolam

B. Chlorpromazine*

C. Diazepam

D. escitalopram

E. Fluoxetine

In the serotonergic pathway, serotonin is synthesized at which one of the following locations?

A. Amygdala

B. Locus cereleus

C. Raphe nuclei*

D. Substantia Nigra

E. Ventral Tegmental Area

Which of the following is the most commonly reported adverse effects of SSRIs?

A. Agitation and restlessness

B. Gastro intestinal upsets*

C. Headache

D. Loss of libido

E. Photophobia

A police constable of 40 years of age was brought to ER of a hospital with alcohol intoxication. Patient
was violent and delirious. Alcohol exerts its pharmacological action through which of the following way?

A. Alcohol is agonist of NMDA receptor

B. Alcohol is agonist of GABA A receptor*

C. Alcohol is antagonist of GABA A receptor

D. Alcohol is antagonist of GABA B receptor

E. Alcohol is agonist of GABA B receptor

An infant of 9 months of age was brought to OPD of a hospital with frequent infantile spasms (hyper
extension of trunk). The doctor on duty prescribed which one of the following drugs to treat this
patient?

A. Phenytoin

B. Vigabatrin*

D. Gabapentin

E. Pregablin

Which of the following is an estrogen that is used in most combined hormonal contraceptives?

a. Clomiphene
b. Estrone
c. Ethinyl estradiol*
d. Diethylstibestrol
 e. Norgestrel

Which of the following is a unique property of selective estrogen receptor modulators (SERMs)?

a. Act as agonist in some tissues and antagonists in others*

b. Activate a unique plasma membrane bound receptor
c. Have both estrogenic and progestational agonist activity
d. Inhibit the aromatase enzyme
e. Produce estrogenic effects without binding to estrogenic receptors

A 40 years old male came to a clinic with symptoms of hyperthyroidism .Which one of the following
drugs would you prefer in order to avoid multiple doses & adverse effects?

A. Carbimazole

B. Levothyroxine

C. Methimazole*

D. Propylthiouracil

E. Sodium iodide

The anti-thyroid drug for the control of hyperthyroidism during pregnancy is

a. Propylthiouracil*
b. Methimazole
c. Carbimazole
d. Lugol’s iodine
e. Radioactive iodine

Female gonadal hormones are necessary for conception, embryonic maturation and development of
primary & secondary sexual characteristics at puberty. Which of the following synthetic pharmacological
preparations are used in replacement therapy if the patient is deficient in these hormones?

A. Diethylstilbestrol*

B. Estradiol

C. Estriol

D. Ethinyl- estradiol
A 53 years bureaucrat having type-2 diabetes mellitus not responding to metformin and glyburide is
prescribed insulin. But the patient is reluctant to use insulin as he has heard about hypoglycemia.
Doctor explains that the insulin he has prescribed does not have any risk of hypoglycemia. Which of the
following insulin was prescribed?

A. Aspart

B. Glargine*

C. Lispro

D. Nph

E. Regular

A50 years, newly diagnosed type - 2 Diabetic male presents to a physician who prescribed metformin for
this problem. Having some background medical knowledge, the patient is interested to know some facts
about the drug. Which of the following was explained by the physician about metformin?

A. It can cause severe hypoglycemia

B. It causes lactic acidosis in almost every patient.

C. It improves insulin sensitivity *

D. It increases hepatic glucose production.

E. It should be used only as mono therapy