AIIMS JUNE 2020 (RECALL QUESTIONS) 1. 70 year old patient has diabetes mellitus and hypertension. He presents with late stage chronic kidney disease. Which of the following anti-diabetic drugs require least dose ‘modification in renal disease? a. Sitagliptin b. Vildagiiptin «. Linagliptin d. Saxagliptin ‘Ans is ¢ Linagliptin Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14” edition, Page: 200 Mobile Application: Pharmacology by Dr Gobind Rai Garg. Chapter pancreas Rapid revision (Pharma T-20) pg 462 2. Which of the following drug can cause the side-effect given in the picture? a. Bleomycin b. Mitomycin C ¢. Doxorubicin d. Actinomycin D 1s isa, Bleomycin (Itis lagellated dermatitis) Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14° edition, Page: 511 Mobile Application: Pharmacology by Dr Gobind Rai Garg chapter anticancer drugs Rapid revision (Pharma T-20) pg 471 Scanned with CamScanner3. A patiant was on metoprolol therapy for hypertension. He was also administered verapamil. Which of the following is likely to happen with above combination therapy? a. Torsades de pointes b. Ventricular tachycardia . Ventricular fibrillation d, Bradycardia with AV block And is d. Bradycardia with AV block Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14” edition, Page: 132 ‘Mobile Application: Pharmacology by Dr Gobind Rai Garg chapter anti-arrhythmics Rapid revision (Pharma T-20) pg 442 4. Allof the following are advantages of enteric coated tablets except a. Itincreases the halt-life of the drug b. Itprotects acid labile drugs from gastric pH «, Itincreases the absorption of drugs that are preferentially absorbed distal to stomach. 4. It protects stomach from irritant drugs Ans is a. It increases the hall-life of the drug Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14” edition, Page: 386 Mobile Application: Pharmacology by Dr Gobind Rai Garg chapter GIT Rapid revision (Pharma T-20) Page 475 5. A psychotropic drug inhibiting the reuptake of serotonin is likely to cause which of the following adverse effect? a. Visual disturbance b. Constipation ¢. Dry mouth , Sexual dysfunction ‘Ans is d. Sexual dysfunction Dry mouth and blurred vision is seen in some SSRIs due to additional anticholinergic action, The increase in serotonin (due to reuptake inhibition) is responsible for sexual dysfunction and diarthea, Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14" edition, Page: 265 Mobile Application: Pharmacology by Dr Gobind Rai Garg Chapter CNS Rapid revision (Pharma T-20) PG 469 Scanned with CamScanner6. Which of the following is a second tine anti-tubercular drug? a. Streptomycin b. Ethionamide , Vancomycin J. Acyclovir Ans is b. Ethionamide Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14" edition, Page: 458 Mobile Application: Pharmacology by Dr Gobind Rai Garg Chapter Anti-mycobacterial 3 / g Rapid revision (Pharma T-20); Pg 453 7. A female with unitateral breast cancer is on tamoxifen therapy. Which of the following adverse offect is associated with the use of tamoxifen? a. Carcinoma in opposite breast b. Endometrial carcinoma ¢, Ovarian carcinoma 4d. Chronic myeloid leukemia Ans is b. Endometrial carcinoma Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14" edition, Page: 207 Mobile Application: Pharmacology by Dr Gobind Ral Garg Chapter Sex hormones Rapid revision (Pharma T-20); Pg 463 8. Combined oral contraceptive pills act by all of the following mechanisms except? a. Inhibit implantation by bringing change in the uterus b. Inhibit ovulation c. Makes cervical mucus thick and hostile d. Increase gonadotropin secration ‘Ans is d. Increase gonadotropin secretion Ref. Review of Pharmacology by Gobind Ral Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14" edition, Page: 209 Mobile Application: Pharmacology by Dr Gobind Ral Garg: Chapter Sex hormones ‘9. Which of the following drug should be avoided in a patient on rosuvastatin therapy? Scanned with CamScannera. Clarithromycin b. Oxycodone «. Rivaroxaban d.Adatimumab Ans is a. Clarithromycin CYP 3A¢ inhibitors like erythromycin, clarithromycin, ketoconazole etc increase the risk of myopathy by inhibiting the metabotism of statins Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14” edition, Page: 140 Mobile Application: Pharmacology by Dr Gobind Rai Garg: Chapter- Anti-dsylipidemic Rapid revision (Pharma T-20): Pg 443, 10. All of the following are bactericidal drugs against Mycobacterium except a. Kanamycin b. Thioacetazone ¢. Rifapentine d. Isoniazid Ans is b. Thioacetazone Ref. Review of Pharmacology by Gobind Ral Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14” edition, Page: 458 Mobile Application: Pharmacology by Dr Gobind Rai Garg: Chapter: Anti-mycobacterial 4 / 8 Rapid revision (Pharma T-20): Pg 452-453, 11. A patient is on long term anticonvulsant therapy. There is progressive contractifty of visual field, The likely anti-epileptic drug responsible for this adverse effect is a. Vigabatrin b. Ethosuximide . Phenobarbital d. Levetiracetam Ans isa. Vigabatrin Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14" edition, Page: 258, Mobile Application: Pharmacology by Dr Gobind Rai Garg: Chapter- Anti-epileptic drugs. Rapid revision (Pharma T-20); Pg 466 12. Which of the following drugs act through intracellular receptors? a. Thyroxin Scanned with CamScannerb. Glucagon ¢. Epinephrine d. Parathyroid hormone Ans is a. Thyroxin Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14” edition, Page: 10 Mobile Application: Pharmacology by Dr Gobind Rai Garg: Chapter Pharmacodynamics Rapid revision (Pharma T-20): Pg 427 13. A resident doctor developed needle prick injury while taking blood sample of HIV positive symptomatic patient. Which of the following regimen is best for post exposure prophylaxis of HIV for this doctor? a. Zidovudine + Lamivudine b. Zidovudine + Lamivudine + indinavir . Zidovudine + Lamivudine + Nevirapine d, Zidovudine + Stavudine + Nevirapine Ans is b. Zidovudine + lamivudine + indinavir Note: The concept of two drug therapy (tenofovir + lamivudine) told by some institutes is totally wrong, For PEP, 3 drugs are given. Tenofovir/zidovudine + Lamivudine + Protease inhibitor/Integrase inhibitor is first line. Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brathers), 14” edition, Page: 469 Mobile Application: Pharmacology by Dr Gobind Rai Garg chapter antiviral drugs Scanned with CamScanner18. Which of the following drug can be used as an antidote for fibrinolytic overdose? a. Ethamsyiate b. Alteplase . Andexanet alpha d. Epsilon amino caproic acid ‘Ans is d. Epsiion amino caproic acld Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14” edition, Page: 352 Mobile Application: Pharmacology by Dr Gobind Rai Garg: Chapter Hematology (Drugs affecting blood flow) 16. Which of the following action is expected on stimulation of muscarinic receptors? a. Erection b. Ejaculation «. Increased contraction of cardiac muscles 4d. Bronchodilation Ans is a. Erection Ref. Review of Pharmacology by Gobind Ral Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14” edition, Page: 48 Mobile Application: Pharmacology by Dr Gobind Rai Garg: Chapter cholinergic drugs 17. Allof the following drugs are indicated in the treatment of NSTEMI except a. Clopidogrel b. Aspirin ¢. Streptokinase d. Prasugrel Ans is ¢. Streptokinase Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14” edition, Page: 133. Mobile Application: Pharmacology by Dr Gobind Rai Garg: Chapter- Ischemic heart disease 18, Which of the following is not a prodrug? a. § Fluorouracil b. Primidone , Proguanil Scanned with CamScannerd. Sulindac Ans is b. Primidone Primidone itself is active as well as produce active metabolite Ref. KDT (Publisher: Jaypee Brothers), 8” edition, Page: 28 19. A 28 year old female with Graves’ disease was taking medication for hyperthyraidism during pregnancy. She delivered a child with congenital anomaly ‘aplasia cutis congenita’. Most likely drug implicated for this teratogenic effect is? a. Carbimazole b. Levo-thyroxine c. Methylthiouracit d. Liothyronine Ans is a. Carbimazole Ref. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14" edition, Page: 620 Mobile Application: Pharmacology by Dr Gobind Rai Garg: Chapter- anti-thyorid drugs. 20. Which of the following antitungal drugs possess additional anthinflammatory and antipruritic activity? a. Terbinafine b. Sertaconazole ¢, Luliconazole d. Ketoconazole Ans is b. Sertaconazole 21. A.30 year old patient was started on lithium carbonate for bipolar disorder. The nurse will gave instructions on adverse effects of the therapy. The patient should report back if the following features are seen a. Palpitations, chest pain, raised blood pressure b. Sedation, constipation, vomiting ¢. Tinnitus, severe diarrhea, ataxia d. Fever, skin rash, bradycardia Ans is c. Tinnitus, severe diarrhea, ataxia GI (Diarthea, vomiting} and CNS (coarse tremors, drowsiness, muscle weakness, ataxia, blurred vision, tinnitus) manifestations are the early indications of lithium toxicity Scanned with CamScannerRef. Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14" edition, Page: 267 22. For plasma level monitoring, lithium estimation is done? a. Immediately after the dose b. B hours after last dose ¢. 12 hours after last dose d. 24 hours after last dose Ans is ¢. 12 hours after last dose Steady state of lithium is reached in approximately 5 days. So, serum levels should be chacked days affer starting the therapy ar change in dose. The sample should be taken 10-12 hours after the last dose. Ref. Katzung 13th Page: 505 23. Dicumaral antagonizes the action of vitamin K by a. Competitive inhibition b. Non-competitive inhibition c. Uncompetitive inhibition 4. Suicide inhibition Ars is a. Competitive inhibition 24. Which of the following is not used in treatment of polycystic ovarian disease? a. Letrozole b, Clomiphene citrate ¢. Ulipristal 4. Combined oral contraceptives Ans is c. Ulipristal Review of Pharmacology by Gobind Rai Garg and Sparsh Gupta (Publisher: Jaypee Brothers), 14” edition, Page: 210 Mobile Application: Pharmacology by Dr Gobind Rai Garg: Chapter- Sex hormones Rapid ravision (Pharma T-20): Pg 464 Scanned with CamScanner