waktu (jam Cp(mcg/ml) Cp Terminal Cp Rasidual Cp Distribusi AUC

0.25 4.2 0.77418054445 3.42581945555 3.490017860968 0.9625

0.5 3.5 0.88740822535 2.61259177465 2.540616718092 1.5
1 2.5 1.16596588455 1.33403411545 1.34636296113 1.875
2 1.25 2.01284637836 -0.7628463784 0.378101293876 1.56
4 0.31
6 0.8

Cp Terminal C
7
4
6
f(x) = 0.675422237386793 exp( 0.546044179008744 x ) 3.5
R² = 1 f(x) = 4.79420699289493 e
5 3 R² = 0.997434664864152

4 2.5
3 2
2 1.5

1 1

0 0.5
0 0.5 1 1.5 2 2.5 3 3.5 4 4.5
0
0.2 0.3 0.4 0.5
Cp y = 0,6754e0,546x
k 0.546 Jam -1 cp y = 0,6754e0,546 + y = 4,7942e-1,27x
t1/2 1.269500330696
 Diskusi 1

Kompartemen 1 terbuka
4.5
4
3.5
3
2.5
2
1.5
1
0.5
0
0 1 2 3 4 5
Cp Distribusi
4

5
f(x) = 4.79420699289493 exp( − 1.26990512619074 x )
3 R² = 0.997434664864152

0
0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1.1

y = 4,7942e-1,27x Cp y = 4,7942e-1,27x
K 1.27 jam -1
t1/2 0.545785
mpartemen 1 terbuka

2 3 4 5 6 7
Waktu (jam ) C ( Microgram/ml Cp terminal Cp Residual Cp Distribusi AUC
2 1.2 1.1995695742 0.0004304258 0.00043032383 2.25
5 0.3

Cp Distribusi
2.5
Cp Term
2.5
2
f(x) = 9293.12303746016 exp( − 8.44388276670962 x ) 2
R² = 1 f(x) = 3.3333333333333
1.5 R² = 1
1.5
1
1

0.5 0.5

0 0
0.8 1 1.2 1.4 1.6 1.8 2 2.2 0.8 1 1.2 1.4

Cp y=9293,1e-8,444x Cp
K 8.444 jam -1 K
T1/2 0.0820875391 T1/2
Cp y=9293,1e-8,444 + y=3,3333e-0,511x
 Diskusi 2

Kompartemen 2 terbuka
6

Cp Terminal 1

0
1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2 2.1

f(x) = 3.33333333333333 exp( − 0.510825623765991 x )

R² = 1

8 1 1.2 1.4 1.6 1.8 2 2.2

y=3,3333e-0,511x
0.511
1.356452
y=3,3333e-0,511x
buka

1.8 1.9 2 2.1

Waktu (Jam Cp (mcg/ml Cp Terminal Cp Residual Cp Distribusi AUC

0.25 8.21 8.226632077939 0.01663207794 0.016385569842 2.01

0.5 7.87 7.884325746845 0.01432574685 0.014671415249 3.775
1 7.23 7.2418500527 0.0118500527 0.011762318329 12.38
3 5.15 5.154533949409 0.00453394941 0.004859332388 12.36
6 3.09
12 1.11
18 0.4

Cp Distribusi Cp Terminal
0.018 3.5
0.016 3
f(x) = 0.0182871070308835 exp( − 0.441637076951761 x ) f(x) = 8.58378776816226 exp( − 0.17037
0.014 R² = 0.985348232863879 R² = 0.999999203501773
2.5
0.012
0.01 2
0.008 1.5
0.006
1
0.004
0.002 0.5

0 0
0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1.1 4 6 8 10 12 14

Cp y = 0,0183e-0,442x Cp y = 8,5838e-0,17x
K 0.442 Jam -1 K 0.17
T1/2 1.56820629086 T1/2 0.117835

Cp y = 0,0183e-0,442x +
 Diskusi 3

Cp Terminal Kompartemen 2 terbuka

9
8
= 8.58378776816226 exp( − 0.170371818565317 x )
= 0.999999203501773 7
6
5
4
3
2
1
0
8 10 12 14 16 18 20 0 2 4 6 8 10 12 14 16 18 20

y = 8,5838e-0,17x
Jam -1

y = 8,5838e-0,17x
erbuka

14 16 18 20
waktu (jam ) Konsentrasi Plasma (mcg/ml) Cp Terminal (mcg/ml) cp Residual (mcg/ml) AUC
0.25 43 14.28 57.28 9.375
0.5 32 13.55 45.55 13
1 20 12.20 32.20 8.5
1.5 14 10.98 24.98 6.25
2 11 9.89 20.89 17.5
4 6.5 6.50 13.00 18.6
8 2.8
12 1.2
16 0.52

Cp Terminal
3

f(x) = 15.049182373916 exp( − 0.210443235573478 x )

2.5 R² = 0.99998564066679

1.5

0.5

0
7 8 9 10 11 12 13 14 15 16 17

Cp 15,049e-0,21x
K 0.21 jam -1 Cp
t1/2 3.30070085980926
 Cp Residual
70.00

60.00
f(x) = 78.334955866781 exp( − 0.28596491683515 x )
50.00 R² = 0.985717809756145

40.00

30.00

20.00

10.00

0.00
15 16 17 0 1 2 3 4 5 6 7

Cp 78,335e-0,286x
= 15,049e-0,21x + 78,335e-0,286x k 1.815 jam - 1
t1/2 0.381899
 Kompartemen 2 Terbuka
50
45
40
35
30
25
20
15
10
5
0
0 2 4 6 8 10 12 14 16 18