EJERCICIO DE APLICACIÓN-2- BIOLOGÍA CELULAR Y MOLECULAR

CLUB DE REVISTA- MEDICINA

21-04-2021

Preparar un Foro en grupo o individual.

Realizar una discusión teniendo en cuenta las siguientes

imágenes y enunciados:

1.- Definition
Acne vulgaris (acne) is a highly prevalent, chronic inflammatory skin disease affecting the

pilosebaceous unit, mainly at the face, neck, upper trunk and back.

The etiology of acne is a complex interplay between androgen-induced sebum production,

follicular keratinization, inflammation, and colonization of pilosebaceous follicles by

Cutibacterium acnes (formerly Propionibacterium acnes). Acne is a multifactorial disease,

and we have recently reviewed that the epidemiological risk factors for acne and acne

severity include demographics, genetics/hormonal, dietary habits and lifestyle factors.

Of note, earlier twin and family studies, have established that acne susceptibility has a

strong genetic component. Multiple case–control familial studies and twin studies

involving numerous ethnicities showed strong heritability with estimates upwards of 78%,

while concordance between monozygotic twins compared with dizygotic twins was higher

for both acne presentation and severity (Figure 1).

Fig. 1 Skin organization and representation of the pilosebaceous unit. Major residents of the pilosebaceous unit, C. acnes
and S. epidermidis, coexist on the skin surface and within the follicle as multiphyletic communities that can interact and
coexist.

Buscar las palabras desconocidas y explica el significado.

Identifica las diferentes células y moléculas que participan en la patogénesis del

acne.

Explica brevemente desde el punto de vista de la Biología celular y molecular la

anterior definición.

2.- Dar una explicación desde la biología celular y molecular para las
manifestaciones clínicas ilustradas en la Figura 2
 A

B C

Figure 2. Clinical manifestations of acne vulgaris. (A) Comedones with post-inflammatory hyperpigmentation.
(B) Inflammatory papules and pustules. (C) Acne Nodules and Cysts.

3.- Dar tu opinión teniendo en cuenta la homeostasis y el tratamiento del

acne vulgar, relacionándolo con los conceptos de la Biología Celular y
Molecular. (Organización del ser humano y los procariotas-Bacterias)
Tener en cuenta la siguiente tabla.

Tabla 1