Kadar (µg/mL) AUC (µg/mL .

jam)

T (jam) Subject
Suspensi Injeksi Kapsul A Kapsul B Kapsul C
Oral Intravena
0.5 2.75 5.31 1 14.1 19.1 9.6
1 6.24 4.62 2 20.2 20 10.6
1.5 8.5 4.02 3 19 17.5 14.6
2 9.81 3.5 4 13.2 20.3 13.1
3 7.43 2.65 5 13.5 17.3 10.4
4 5.6 2.01 6 17.9 17.4 8.3
6 3.19 1.16 7 12.4 17.2 14.5
8 1.91 0.66 8 15.8 16.9 11.4
rata-rata
F? standar deviasi
Konsentrasi dari oral: 50 mg/ml 10 ml rata-rata standar deviasi
Konsentrasi dari IV: 100 mg/ml2 ml α= 0.05, tα= 1.895
Cl(+)
Cl(-)
/mL .jam) F

Kapsul
Kapsul A Kapsul B Kapsul C
STD

15.8 89.24051 120.8861 60.75949 80%-125% KESIMPULAN

19 106.3158 105.2632 55.78947 Kapsul A 79 - 99,06 tidak bioekivalensi
19.3 98.4456 90.67358 75.64767 Kapsul B 96,87 - 109,59 bioekivalensi
18.4 71.73913 110.3261 71.19565 Kapsul C 58,12 - 71,96 tidak bioekivalensi
17.2 78.48837 100.5814 60.46512
16.5 108.4848 105.4545 50.30303
17.9 69.27374 96.08939 81.00559
17.5 90.28571 96.57143 65.14286
89.03421 103.2307 65.03861
asi 14.9665 9.495696 10.33253
deviasi 5.291459 3.357235 3.6531
.895 10.02731 6.361961 6.922625
99.06153 109.5927 71.96124
79.0069 96.86875 58.11598
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit μg/ml Analyst Asus X441B
Dose 10 Date 2022-3-28
Dose Unit mg/ml Time 22:33:55

Time Conc ln(Conc) Conc_pre Residual Weight Parameter

0.5 2.75 1.01160091 7.02417623 -4.27417623 1 A
1 6.24 1.83098018 8.51771599 -2.27771599 1 ka
1.5 8.5 2.14006616 7.74661894 0.75338106 1 k10
2 9.81 2.28340227 6.26251425 3.54748575 1
3 7.43 2.00552586 3.45331055 3.97668945 1 Parameter
4 5.6 1.7227666 1.69266142 3.90733858 1 t1/2ka
6 3.19 1.16002092 0.34312552 2.84687448 1 t1/2k10
8 1.91 0.64710324 0.06182779 1.84817221 1 V/F
CL/F
12 Tmax
Cmax
Observed AUC 0-t
10 Predicted AUC 0-inf
AUMC
MRT
8
Concentration (μg/ml)

Diagnostics
r obs-pre
6 SS
WSS
R^2
4 WR^2
SE
AIC
2 SC

0
0 1 2 3 4 5 6 7 8 9
Time (h)

10

Observed
Predicted
Concentration (μg/ml)

1
Concentrat

1
0 1 2 3 4 5 6 7 8 9
Time (h)

Residual Plot
5

2
Residual (μg/ml)

0
0 1 2 3 4 5 6 7 8 9
-1

-2

-3

-4

-5
Time (h)
 Unit Value Time Conc_Pre
μg/ml 16227.30153 0 0
1/h 1.0014278459 0.08080808 1.72688289
1/h 1 0.16161616 3.18546858
0.24242424 4.40702006
Unit Value 0.32323232 5.41956223
h 0.6921588843 0.4040404 6.24819628
h 0.6931471806 0.48484848 6.91538485
(mg/ml)/(μg/ml) 0.4322072128 0.56565657 7.44121047
(mg/ml)/(μg/ml)/h 0.4322072128 0.64646465 7.84360981
h 0.9992867559 0.72727273 8.13858585
μg/ml 8.5177181613 0.80808081 8.34040012
μg/ml*h 23.067548995 0.88888889 8.46174664
μg/ml*h 23.137050246 0.96969697 8.51390943
μg/ml*h^2 46.241111453 1.05050505 8.50690494
h 1.9985741899 1.13131313 8.44961092
1.21212121 8.34988287
Value 1.29292929 8.2146593
0.535860684533 1.37373737 8.05005679
79.210599357328 1.45454545 7.86145582
79.210599357328 1.53535354 7.65357821
0.7488370225654 1.61616162 7.430557
0.7488370225654 1.6969697 7.19599944
3.98021605839 1.77777778 6.9530437
40.976880961082 1.85858586 6.70441002
41.215205586121 1.93939394 6.45244669
2.02020202 6.19917142
2.1010101 5.94630853
2.18181818 5.69532235
2.26262626 5.44744723
2.34343434 5.20371441
2.42424242 4.96497614
2.50505051 4.73192728
2.58585859 4.50512456
2.66666667 4.2850039
2.74747475 4.07189581
2.82828283 3.8660391
2.90909091 3.66759319
2.98989899 3.47664895
3.07070707 3.29323841
3.15151515 3.11734338
3.23232323 2.948903
3.31313131 2.78782055
3.39393939 2.63396931
3.47474747 2.48719787
3.55555556 2.34733471
3.63636364 2.21419222
3.71717172 2.08757027
3.7979798 1.96725923
3.87878788 1.85304274
3.95959596 1.74469993
4.04040404 1.64200749
4.12121212 1.54474135
4.2020202 1.45267815
4.28282828 1.36559651
4.36363636 1.28327802
4.44444444 1.20550816
4.52525253 1.13207698
4.60606061 1.06277972
4.68686869 0.99741723
4.76767677 0.93579636
4.84848485 0.87773024
4.92929293 0.82303844
5.01010101 0.7715471
5.09090909 0.72308903
5.17171717 0.6775037
5.25252525 0.6346372
5.33333333 0.59434222
5.41414141 0.5564779
5.49494949 0.52090977
5.57575758 0.48750958
5.65656566 0.45615515
5.73737374 0.42673019
5.81818182 0.39912413
5.8989899 0.37323196
5.97979798 0.34895399
6.06060606 0.32619567
6.14141414 0.3048674
6.22222222 0.28488436
6.3030303 0.26616624
6.38383838 0.2486371
6.46464646 0.23222518
6.54545455 0.21686268
6.62626263 0.20248559
6.70707071 0.18903353
6.78787879 0.17644954
6.86868687 0.16467992
6.94949495 0.15367409
7.03030303 0.14338441
7.11111111 0.13376603
7.19191919 0.12477675
7.27272727 0.11637686
7.35353535 0.10852906
7.43434343 0.10119824
7.51515152 0.09435144
7.5959596 0.08795772
7.67676768 0.08198798
7.75757576 0.07641494
7.83838384 0.071213
7.91919192 0.06635813
8 0.06182779
PKSolver 2.0 Compartmental Analysis of Plasma Data after Intravenous Bolus Input

Time Unit h
Conc Unit μg/ml Analyst Asus X441B
Dose 2 Date 2022-3-28
Dose Unit mg/ml Time 22:36:08

Time Conc ln(Conc) Conc_pre Residual Weight Parameter

0.5 5.31 1.66959184 6.82741361 -1.51741361 1 C0
1 4.62 1.53039471 4.14103568 0.47896432 1 k10
1.5 4.02 1.3912819 2.5116651 1.5083349 1
2 3.5 1.25276297 1.52340189 1.97659811 1 Parameter
3 2.65 0.97455964 0.56042824 2.08957176 1 t1/2
4 2.01 0.69813472 0.20617003 1.80382997 1 V
6 1.16 0.14842001 0.02790208 1.13209792 1 CL
8 0.66 -0.41551544 0.00377614 0.65622386 1 AUC 0-t
AUC 0-inf
8 AUMC
MRT
Observed Vss
7
Predicted
Diagnostics
6 r obs-pre
SS
Concentration (μg/ml)

5 WSS
R^2
4 WR^2
SE
3 AIC
SC
2

0
0 1 2 3 4 5 6 7 8 9
Time (h)

10

Observed
Predicted
1
Concentration (μg/ml)

0.1

0.01

0.001
 0.1

Concentrat 0.01

0.001
0 1 2 3 4 5 6 7 8 9
Time (h)

Residual Plot
2.5

1.5

1
Residual (μg/ml)

0.5

0
0 1 2 3 4 5 6 7 8 9
-0.5

-1

-1.5

-2
Time (h)
s Bolus Input

Unit Value Time Conc_Pre

μg/ml 11.256502041 0.5 6.82741361
1/h 1 0.57575758 6.32929177
0.65151515 5.86751244
Unit Value 0.72727273 5.43942411
h 0.6931471806 0.8030303 5.04256871
(mg/ml)/(μg/ml) 0.1776750888 0.87878788 4.67466752
(mg/ml)/(μg/ml)/h 0.1776750888 0.95454545 4.33360806
μg/ml*h 11.252725905 1.03030303 4.01743199
μg/ml*h 11.256502041 1.10606061 3.72432384
μg/ml*h^2 11.256502041 1.18181818 3.45260058
h 1 1.25757576 3.20070201
mg/ml/(μg/ml) 0.1776750888 1.33333333 2.96718172
1.40909091 2.75069886
Value 1.48484848 2.5500104
0.9019798910208 1.56060606 2.36396397
18.046353312045 1.63636364 2.19149133
18.046353312045 1.71212121 2.03160213
0.801240013877 1.78787879 1.8833783
0.801240013877 1.86363636 1.74596875
1.7342795484026 1.93939394 1.61858447
27.143549054351 2.01515152 1.50049403
27.302432137711 2.09090909 1.39101936
2.16666667 1.28953186
2.24242424 1.1954488
2.31818182 1.10822995
2.39393939 1.02737451
2.46969697 0.95241821
2.54545455 0.88293065
2.62121212 0.81851284
2.6969697 0.75879489
2.77272727 0.70343391
2.84848485 0.65211202
2.92424242 0.60453452
3 0.56042824
3.07575758 0.51953991
3.15151515 0.48163475
3.22727273 0.44649512
3.3030303 0.41391925
3.37878788 0.38372008
3.45454545 0.35572421
3.53030303 0.3297709
3.60606061 0.30571112
3.68181818 0.28340671
3.75757576 0.26272962
3.83333333 0.24356111
3.90909091 0.22579111
3.98484848 0.2093176
4.06060606 0.19404598
4.13636364 0.17988856
4.21212121 0.16676406
4.28787879 0.15459711
4.36363636 0.14331784
4.43939394 0.1328615
4.51515152 0.12316805
4.59090909 0.11418182
4.66666667 0.10585122
4.74242424 0.09812841
4.81818182 0.09096905
4.89393939 0.08433204
4.96969697 0.07817925
5.04545455 0.07247536
5.12121212 0.06718762
5.1969697 0.06228568
5.27272727 0.05774137
5.34848485 0.05352861
5.42424242 0.04962322
5.5 0.04600275
5.57575758 0.04264643
5.65151515 0.03953499
5.72727273 0.03665055
5.8030303 0.03397656
5.87878788 0.03149766
5.95454545 0.02919962
6.03030303 0.02706924
6.10606061 0.0250943
6.18181818 0.02326344
6.25757576 0.02156616
6.33333333 0.01999271
6.40909091 0.01853406
6.48484848 0.01718183
6.56060606 0.01592826
6.63636364 0.01476615
6.71212121 0.01368883
6.78787879 0.0126901
6.86363636 0.01176424
6.93939394 0.01090594
7.01515152 0.01011025
7.09090909 0.00937261
7.16666667 0.0086888
7.24242424 0.00805487
7.31818182 0.00746719
7.39393939 0.00692239
7.46969697 0.00641734
7.54545455 0.00594914
7.62121212 0.0055151
7.6969697 0.00511272
7.77272727 0.0047397
7.84848485 0.0043939
7.92424242 0.00407332
8 0.00377614
PKSolver 2.0 Non-Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h Method Linear Trapezoidal

Conc Unit μg/ml Analyst Asus X441B
Dose 10 Date 2022-3-28
Dose Unit mg/ml Time 22:37:35

Time Conc ln(C) AUC AUMC R R_adj

0.5 2.75 1.01160091 0.6875 0.34375
1 6.24 1.83098018 2.935 2.2475
1.5 8.5 2.14006616 6.62 6.995
2 9.81 2.28340227 11.1975 15.0875 -0.9997928 0.99944753
3 7.43 2.00552586 19.8175 36.0425 -0.9997197 0.99915922
4 5.6 1.7227666 26.3325 58.3875 -0.99964255 0.99857047
6 3.19 1.16002092 35.1225 99.9275
8 1.91 0.64710324 40.2225 134.3475

12

10

8
Concentration (μg/ml)

0
0 1 2 3 4 5 6 7 8 9
Time (h)

10
Concentration (μg/ml)

1
0 1 2 3 4 5 6 7 8 9
 1

Concentrat
0 1 2 3 4 5 6 7 8 9

0.1
Time (h)

10
Concentration (μg/ml)

1
0 1 2 3 4 5 6 7 8 9

0.1
Time (h)
vascular Input

Parameter Unit Value

Lambda_z 1/h 0.2739296094
t1/2 h 2.5303842916
Tmax h 2
Cmax μg/ml 9.81
Tlag h 0
Clast_obs/Cmax 0.1946992864
AUC 0-t μg/ml*h 40.2225
AUC 0-inf_obs μg/ml*h 47.19509418
AUC 0-t/0-inf_obs 0.8522601914
AUMC 0-inf_obs μg/ml*h^2 215.58221658
MRT 0-inf_obs h 4.5678946154
Vz/F_obs (mg/ml)/(μg/ml) 0.7735068512
Cl/F_obs (mg/ml)/(μg/ml)/h 0.2118864296
PKSolver 2.0 Non-Compartmental Analysis of Plasma Data after Intravenous Bolus Input

Time Unit h Method Linear Trapezoidal

Conc Unit μg/ml Analyst Asus X441B
Dose 2 Date 2022-3-28
Dose Unit mg/ml Time 22:38:19

Time Conc ln(C) AUC AUMC R R_adj

0.5 5.31 1.66959184 2.85326299 0.66375 -0.99999419 0.99998644
1 4.62 1.53039471 5.33576299 2.4825 -0.99999292 0.99998301
1.5 4.02 1.3912819 7.49576299 5.145 -0.99999108 0.9999777
2 3.5 1.25276297 9.37576299 8.4025 -0.99998817 0.99996845
3 2.65 0.97455964 12.450763 15.8775 -0.9999818 0.99994539
4 2.01 0.69813472 14.780763 23.8725 -0.99997282 0.9998913
6 1.16 0.14842001 17.950763 38.8725
8 0.66 -0.41551544 19.770763 51.1125

4
Concentration (μg/ml)

0
0 1 2 3 4 5 6 7 8 9
Time (h)

10
Concentration (μg/ml)

0.1
 1

Concentrat

0.1
0 1 2 3 4 5 6 7 8 9
Time (h)

10
Concentration (μg/ml)

0.1
0 1 2 3 4 5 6 7 8 9
Time (h)
enous Bolus Input

Parameter Unit Value

Lambda_z 1/h 0.2775217685
t1/2 h 2.4976317511
Tmax h 0.5
Cmax μg/ml 5.31
C0 μg/ml 6.1030519481
Clast_obs/Cmax 0.1242937853
AUC 0-t μg/ml*h 19.770762987
AUC 0-inf_obs μg/ml*h 22.148954808
AUC 0-t/0-inf_obs 0.8926273568
AUMC 0-inf_obs μg/ml*h^2 78.707422962
MRT 0-inf_obs h 3.5535502078
Vz_obs (mg/ml)/(μg/ml) 0.325371646
Cl_obs (mg/ml)/(μg/ml)/h 0.0902977146
Vss_obs (mg/ml)/(μg/ml) 0.3208774625