Micro-organisms

Current overview of the micro-organisms used by DSM and their applications

2011
1
I: classical micro-organism; II: homologous or self-cloned GMM (genetically modified micro-organism); III heterologous GMM

Production I II III Product Food & Pharma & Energy,

Micro-organism Feed Fine Environment
Chemicals &
Biomaterials
Aspergilus niger z z Acid amylase z -
Aspergilus niger z Acid lactase z -
Aspergilus niger z Asparaginase z -
Aspergilus niger z Arabanase z -
Aspergilus niger z z Arabinofuranosidase z -
Aspergilus niger z Beta-galactosidase z -
Aspergilus niger z Citric acid z z
Aspergilus niger z Carboxypeptidase z -
Aspergilus niger z Fungal lipase z -
Aspergilus niger z Glucoamylase z -
Aspergilus niger z Glucose oxidase z -
Aspergilus niger z Glycosidase z
Aspergilus niger z Hemicellulase z -
Aspergilus niger z Lipase z -
Aspergilus niger z Pectinase z -
Aspergilus niger z z Pectin methylesterase z -
Aspergilus niger z Peroxidase z -
Aspergilus niger z Phospholipase A1 z -
Aspergilus niger z Phospholipase A2 z -
Aspergilus niger z Phytase z -
Aspergilus niger z Polygalacturonase z -
Micro-organisms
Current overview of the micro-organisms used by DSM and their applications
2011
1
I: classical micro-organism; II: homologous or self-cloned GMM (genetically modified micro-organism); III heterologous GMM

Production I II III Product Food & Pharma & Energy,

Micro-organism Feed Fine Environment
Chemicals &
Biomaterials
Aspergilus niger z z Protease, endo- z -
Aspergilus niger z z Xylanase z -
Aspergilus niger z Xylanase, thermostable z -
Aspergilus niger var. awamori z Lactoferrin - z
Aspergillus oryzae z Fungal amylase z -
Aspergillus oryzae z Acid lactase z -
Bacillus amyloliquefaciens z z Alpha-amylase z -
Bacillus amyloliquefaciens z Amylomaltase z -
Bacillus amyloliquefaciens z z Beta-glucanase z -
Bacillus amyloliquefaciens z z Neutral protease z -
Bacillus amyloliquefaciens z Maltogenic amylase z -
Bacillus amyloliquefaciens z Mixed enzyme cocktail z
Bacillus licheniformis z z Alpha-amylase, thermostable z -
Bacillus licheniformis z Protease z -
Bacillus subtilis z Bacterial xylanase z -
Bacillus subtilis z Maltogenic amylase z -
Bacillus subtilis z Vitamin B2 z z
Bifidobacterium animalis spp. z Starter culture / Probiotic z -
lactis 1
Blakeslea trispora z Beta carotene z -

1
formerly Bifidobacterium lactis
Micro-organisms
Current overview of the micro-organisms used by DSM and their applications
2011
1
I: classical micro-organism; II: homologous or self-cloned GMM (genetically modified micro-organism); III heterologous GMM

Production I II III Product Food & Pharma & Energy,

Micro-organism Feed Fine Environment
Chemicals &
Biomaterials
Brevibacterium linens z Starter culture z -
Chryphonectria parasitica 2 z Rennet z -
Disporotrichum dimorphosporum z Beta-glucanase z -
Enterococcus faecium z Animal Probiotic z -
Escherichia coli z Glutaryl-acylase - z
Escherichia coli z z Penicillin/cephalosporin-acylase - z
Escherichia coli z Aminopeptidase - z
Escherichia coli z Aldolase - z
Escherichia coli z L-amidase - z
Escherichia coli z Shikimate - z
Escherichia coli z Esterase - z
Escherichia coli z Nitrilase - z
Escherichia coli z Hydantoinase/racemase/carbamoylase z
Escherichia coli z Phenylalanine-ammonia-lyase - z
Glarea lozoyensis z Caspofungin precursor - z
Geobacillus stearothermophilus 3 z Antibiotic residue tests z -
Gluconobacter oxydans z Vitamin C intermediate z z
Kluyveromyces lactis z Chymosin z -
Kluyveromyces lactis z z Neutral lactase z -

2
formerly Endothia parasitica
3
Formerly Bacillus stearothermophilus
Micro-organisms
Current overview of the micro-organisms used by DSM and their applications
2011
1
I: classical micro-organism; II: homologous or self-cloned GMM (genetically modified micro-organism); III heterologous GMM

Production I II III Product Food & Pharma & Energy,

Micro-organism Feed Fine Environment
Chemicals &
Biomaterials
Kluyveromyces lactis z Lipase z -
Lactobacillus acidophilus z Starter culture / Probiotic z -
Lactobacillus delbruckii ssp z Starter culture z -
bulgaricus
Lactobacillus rhamnosus z Starter culture z -
Lactobacillus casei z Starter culture / Probiotic z -
Lactobacillus helveticus z Starter culture z -
Lactococcus lactis ssp cremoris z Starter culture z -
Lactococcus lactis ssp lactis z Starter culture z -
biovar diacetylactis
Lactococcus lactis ssp lactis z Starter culture z -
Leuconostoc mesenteroides ssp z Starter culture z -
cremoris
Leptographium procerum 4 z Phosphodiesterase z -
Mortierella alpina z Arachidonic acid z -
Mucor miehei z Rennet z -
Mucor miehei z Esterase / lipase z -
Penicillium brevicompactum z Mycophenolate - z
Penicillium chrysogenum z Penicillin-G - z
Penicillium chrysogenum z 6-Amino penicillanic acid (6-APA) - z
4
formerly Verticicladiella procera
Micro-organisms
Current overview of the micro-organisms used by DSM and their applications
2011
1
I: classical micro-organism; II: homologous or self-cloned GMM (genetically modified micro-organism); III heterologous GMM

Production I II III Product Food & Pharma & Energy,

Micro-organism Feed Fine Environment
Chemicals &
Biomaterials
Penicillium chrysogenum z 7-Aminodesacetoxy-cephalosporanic - z
acid (7-ADCA)
Penicillium chrysogenum z Pravastatin - z
Pichia pastoris z Hydroxy-nitrile-lyase - z
Propionibacterium freudenreichii z Starter culture z -
Rhizopus oryzae z Fungal lipase z -
Saccharomyces cerevisiae z Alcohol yeast z -
Saccharomyces cerevisiae z Invertase z -
Saccharomyces cerevisiae z Trienol (= cholesta-5, 7, 24-trienol) z z
Saccharomyces cerevisiae z Yeast extract z -
Saccharomyces cerevisiae z Wine yeast z -
Streptococcus thermophilus z Starter culture z -
Streptomyces clavuligerus z Clavulanic acid - z
Streptomyces natalensis z Natamycin z
Streptomyces noursei z Nystatin - z
Talaromyces emersonii z Beta-glucanase z -
Trichoderma longibrachiatum 5 z Hemicellulase z -
Trichoderma reesei 6 z Cellulase z -
Trichoderma reesei6 z Beta-glucanase z -
5
Also known as Trichoderma reesei
6
formerly Trichoderma longibrachiatum
Micro-organisms
Current overview of the micro-organisms used by DSM and their applications
2011
1
I: classical micro-organism; II: homologous or self-cloned GMM (genetically modified micro-organism); III heterologous GMM

Production I II III Product Food & Pharma & Energy,

Micro-organism Feed Fine Environment
Chemicals &
Biomaterials
Trichoderma reesei6 z Mixed enzymes cocktail - - z