1.

Periosteal osteoma, endosteal osteoma

2. Radiopaque

3. Compact osteoma, cancellous osteoma

4. Gardner syndrome

5. Osteoblasts

6. Osteoid tissue , Prostagladin E2, Aspirin

7. Larger in size (more than 2mm)

8. Osteoblastoma

9. Vascularity of lesion with many dilated cappilaries throughout the tissue, Multinucleate
giant cell, actively proliferating osteoblasts.

10. Bone (mesenchymal origin)

11. 10-25 yrs ( ADOLESCENT)

12. 8%

13. 33yrs

14. Jaw osteosarcoma, Occlusal radiograph

15. Codman's triangle

16. Metastatic tumor of jaw

17. Third

18. Osteoid

19. Osteoblastic, chondroblastic, fibroblastic, small cell, giant cell rich, telangiectatic

20. Tumor osteoid

21. Ewing's sarcoma

22. Primitive neuro ectodermal tumor (PNET)

23. 5yrs (children) and 25yrs (young adults)

24. Onion skin aappearance

25. Glycogen

26. Filligree pattern

27. CD-99

28. Torus palatinus

29. Torus mandibularis

30. Above

31. Plasma cell

32. Numerous sharply punched out areas

33. Bence Jones proteins

34. Amyloid

35. Lymphatic system, particularly B-Lymphocytes

36. Starry sky appearance

37. Children, jaw

38. 3-7 yrs

39. EEBV

40. Lymphocytic depleted HD

41. False

42. Lipoblasts

43. A person on starvation diet, will loose fat from normal fat depots in body, but not from
lipoma, furthermore fatty acid precursor are incorporated at a more rapid rate into
lipoma fat than into normal fat while Lipoprotein lipase activity is reduced.
44. HODGKIN'S LYMPHOMA:
It is a type of malignant lymphoma.

Etiology:
● Almost 100% of HIV-associated HD
cases are EBV-positive.
● Genetic predisposition

Clinical consideration:
• Bimodal distribution,
In young adults(aged 15-34 years) & older individuals (>55 years).
• more common in Males
•Painless enlargement of one or more cervical lymph nodes.
● Palpable painless lymphadenopathy
occurs in the cervical area.
● Lymph nodes are firm & rubbery in
consistency.
● Unexplained weight loss, fever, night
sweats present in about 40% of
patients.

ORAL MANIFESTATIONS:
• Primarily a disease of lymph nodes.
It rarely occurs as a disease primarily
in the oral cavity. Oral cavity could be
involved secondarily.

Histology:
REED--STENBERG CELL: characteristic malignant cell of HODGKIN'S lymphoma.
types:
(1) Nodular Sclerosis HD:

• Comprises 60-80% of all cases.

• Nodular pattern
•The characteristic cell is the lacunar type RS cell, which has a multilobated
nucleus with abundant & pale cytoplasm.

(2) mixed- cellularity HD:

• 15-30% cases.
• Diffuse infiltrate.
• RS cells of classic type seen.

(3) lymphocyte- depleted HD

• < 1% cases
• Infiltrate is diffuse & often appears
hypocellular.
• Large numbers of RS cells.
• Associated with older age & HIV
positivity

(4)lymphocyte-rich classic HD:

• RS cells of the classic or lacunar type
observed.

(5) nodular lymphocyte-predominant HD:

•constitutes 5%.
• A variant of RS cells, the lymphocytic & histiocytic cells or popcorn cells are seen.

TREATMENT & PROGNOSIS:

•Nodular lymphocyte predominant type
has the most favorable prognosis,
followed by nodular sclerosis, mixed
cellularity.
• Lymphocyte depletion has the least
favorable prognosis.

45: BURKITT'S LYMPHOMA:

Or AFRICAN JAW LYMPHOMA:
Peculiar to children of central Africa.
•It was Reported by Burkitt.
•it also occurs sporadically throughout
the world.
• High-grade B-cell neoplasm with 2
major forms- African( endemic) and
sporadic( non-endemic).
• it Is one of the fastest growing
malignancies in humans.

Etiology &CLINICAL FEATURES

EBV -African form

• African form most often involves the

maxilla or mandible, swelling of the affected jaw or other facial bones.
•loosening of the teeth
•swelling of the lymph nodes,
which are non tender and rapidly
 growing, in the neck or below the jaw. •Abdominal presentation less common.

Histology:

Characteristic ‘starry sky appearance’

imparted by scattered macrophages
with an abundant clear cytoplasm,
often containing phagocytic cellular
debris.

Monoclonal proliferation of B lymphocytes.

Burkitt cells are homogeneous in size &

shape, have round to oval nuclei.

Basophilic vacuolated cytoplasm.

Freq. Mitotic fig.

Treatment and prognosis:

With combination of chemotherapy and CNS prophylaxis , survival rate is now 60% .

Those with CNS and bone marrow involvement has poor prognosis.

Adults with disease, especially in advance stage do more poorly than children.