CASE STUDY IN ANTIHISTAMINE

UNIVERSIDAD DE ZAMBOANGA

CASE STUDY O ANTIHISTAMINE DRAFTS

1. Antihistamine blocks the effect of the chemical mediator histamine, which release
during the inflammatory response. When could taking an anti-histamine to be
harmful and when could it be beneficial?

Antihistamines are drugs that can be taken for many years without causing severe
side effects. Furthermore, antihistamines that minimize histamine-induced reactions in a variety
of ways, including decreasing histamine production, enhancing neutralization, inhibiting receptor
access, and decreasing mast cell discharge, are commonly utilized in clinical practice. Even a
basic medication, however, can result in some negative effects. This medication should only be
used under the guidance of a doctor or an ENT. Depending on the amount taken and the body's
reaction to the chemical, side effects might be abrupt or persistent.

Though antihistamines are among the safest medications on the market, they work by
inhibiting a histamine chemical produced by the body to avoid infection if it detects a foreign
substance. The dosage is decided by the chemical being used, as well as your age, medical
condition, and response to treatment. You should not raise the dose or use this medication
more frequently than suggested without the doctor's approval. Improper use of this medicine
could have disastrous results. Furthermore, in some trials, the combination of an antihistamine
with a leukotriene receptor antagonist was demonstrated to have synergistic effects.

In conclusion, it has been established that increasing antihistamine doses more than
fourfold resulted in a satisfactory therapy response in half of patients with just a little increase in
unpleasant effects. The need for alternate third-line therapies could be greatly minimized. A
prospective controlled study is required to corroborate these findings.

References:

● (Luss L.V. Use of antihistamines in a physician's clinical practice // Terapevticheskii arkhiv. - 2014. - Vol. 86. - N. 8. - P.
106-109.)
● Vermeulen J, Mercer M. Comparison of the effi cacy and tolerability of topical levocabastine and sodium cromoglycate in
the treatment of seasonal allergic rhinoconjuncti

2. Describe the process of tissue repair when the edges of the wound are close
together versus when they are far apart.
 Tissue repair is the process of compensatory regeneration of a tissue following surgical,
mechanical, or chemical harm, culminating in the restoration of the tissue's structure and
function. TR is distinguished by cell division to increase the number of cells, differentiation and
specification of freshly divided cells, angiogenesis (regeneration of blood vessels to restore
blood supply), and regeneration of extracellular matrix (which binds the tissue together).

It has been established that increasing antihistamine doses more than fourfold resulted
in a satisfactory therapy response in half of patients with just a little increase in unpleasant
effects. The need for alternate third-line therapies could be greatly minimized. A prospective
controlled study is required to corroborate these findings. The wound-healing assay is simple,
inexpensive, and one of the earliest developed methods to study directional cell migration in
vitro. This approach simulates cell movement during wound healing. The basic processes entail
making a "wound" in a cell monolayer, capturing photos at the start and at regular intervals
throughout cell migration to close the wound, and comparing the images to calculate the cell
migration rate. It is especially well suited for research into the effects of cell-matrix and cell-cell
interactions on cell migration. Furthermore, wound healing is the process by which the body
restores damaged tissues following any form of injury, such as skin abrasions, ulcers, cut
injuries, and so on.

Acute wounds normally heal quickly, however chronic wounds take much longer, often
months, to heal. Tissues in our bodies are classified into three types based on their ability to
regenerate: labile tissues, stable tissues, and permanent tissues. Although some tissues
resume their previous structure after healing, this is referred to as resolution. Tissues must,
however, contain cells capable of regeneration.

Reference: Todaro, G. J., Lazar, G. K., and Green, H. (1965) The initiation of cell division in a contact-inhibited mammalian cell line.
J. Cell Physiol. 66, 325–333.