Morbidity Associated with Bacterial Vaginosis In pregnant women:

Amniotic fluid infection

Clinical chorioamnionitis
Postpartum endometritis
Premature rupture of the membranes
Preterm delivery
Low birth weight

In pregnant women, bacterial vaginosis is associated with the presence of fetal fibronectin. Women
with fetal fibronectin have a 16-fold increase in clinical chorioamnionitis and a six-fold increase in
neonatal sepsis. The microorganisms found in bacterial vaginosis are also commonly found in the
amniotic fluid of women with amniotic fluid infection. Women with bacterial vaginosis have an odds
ratio of 1.85 (confidence interval: 1.16 to 2.9) for intra-amniotic infection. Bacterial vaginosis in women
at 23 to 26 weeks of gestation is associated with intra-amniotic fluid infection at term.

The odds ratio for premature rupture of the membranes is 7.3 in women with bacterial vaginosis.
Bacterial vaginosis has been associated with low birth weight and preterm birth, with odds ratios for
preterm birth estimated to be from 1.8 to 2.8.

COVID-19 DURING PREGNANCY

Seropositivity for SARSCoV2 suggests that infection occurred earlier during pregnancy was not
associated with selected adverse maternal or neonatal outcomes among live births in a cohort sample.
They found no indication of adverse pregnancy outcomes among live births related to SARSCoV-
2 seropositivity during pregnancy
RESEARCH ARTICLE
SARSCoV2 during pregnancy and associated outcomes: Results from an ongoing prospective cohort
Accepted: 13 August 2021, by Nina M. Molenaar et. al.