Capitol I

 DRUG DISCOVERY: OVERVIEW OF PROCESS

 ANTIBIOTIC DRUG DEVELOPMENT: A HISTORICAL PERSPECTIVE
 Penicillin: A Landmark “Bench to Bedside” Breakthrough
 The Antibiotic Era
 Antibiotic Innovation Gap
 Collapse of the Waksman Platform
 Golden Age of Medicinal Chemistry
 Adherence to Lipinski ‘Rule of Five’
 Phenotypic Versus Target-Based Screens
 High-Risk Investments
 Emergence of Resistance
 Addressing the Unmet Clinical Need
 CONCLUSION