Yo NA Nipa Laboratories Ltd. Uanewit Ferdre, Pontypridd, Mid Glamorgan. CF38 2SN, United Kingcom, Telepnone: 01443 205311 Teetax: 01443 207746 HEALTH AND SAFETY DATA SHEET FOR NIPASOL M 633 IDENTIFICATION OF PRODUCT Commercial Name ‘Nipasol M Chemical Name Propyl paraben Application Antimicrobial preservative Name and address of supplier _Nipa Laboratories Limi Llantwit Fardre Pontypridd Mid Glamorgan (CF38 2SN Tel: 01443 205311 Fax: 01443 207746 COMPOSITIONANFORMATION ON INGREDIENTS Chemical Description Propyl ester of 4-hydroxybenzoic acid Substance CAS EINECS) RNo. Propyl 4-hydroxybenzoate 9413-3 202-307-7 Notrequired >99.0% HAZARDS IDENTIFICATION Slightly i Not considered or regulated as a hazardous product under national & intemational regulations and codes. tating to eyes and skin Dust in confined conditions can be a dangerous fire and explosion hazard. FIRST AID MEASURES Eyes Immediately gently irrigate with clean water for at least 15 minutes. Secke specialist medical advice as soon as possible. Skin ‘Wash affected skin with soap and plenty of water. [firritation develops, seek medical attention. Ingestion Give one pint of water to drink as soon as possible. Consult doctor if any symptoms appear or you feel unwell632 FIRE FIGHTING MEASURES Extinguishing Media __Extinguishing media appropriate to surrounding materials. Fire and Explosion Ef involved in a fire irritating furnes may be evolved and thick black smoke. Protective Measures In emergency situations the use of a self contained breathing apparatus may be necessary. ACCIDENTAL RELEASE MEASURES (Spillage) Personal Precautions Wear PVC gloves and goggles, Wear a dust mask in confined spaces. Environmental Precautions Prevent entry into drains, sewers and water courses. Recovery ‘Sweep up carefully - avoid creating airbome dust and put in lidded plastic containers. Flush away residues with copious amounts of water. HANDLING AND STORAGE (in normal use) Storage ‘No special precautions necessary apart from clean dry conditions. Take precautionary measures against static discharges, Ventilation Good general ventilation, natural or mechanical. Handling ‘Wear PVC gloves and goggles. EXPOSURE CONTROLS/PERSONAL PROTECTION (normal use) Occupational Exposure Limits - None established Engineering Measures Mechanical extraction if the natural ventilation is poor. Personal Protective Equipment Respiratory tn poorly ventlated ares wear dust mask Hand ‘Wear PVC glaves. . Eye Wear safety glasses with side shields. PHYSICAL/CHEMICAL PROPERTIES Appearance White powder Odour Almost odourless pH (as delivered) 7 (to si acidic) Melting point 95 - 98°C. Relative density (SG) 0.74 Solubility 0.04% (water) Partition Coefficient log P octanol/water = 3.04 Other Tasteless but producing a slight burning sensation of mouth and tongue followed by local numbness10. i. 2 13. 632 STABILITY AND REACTIVITY Stability Stable in ambient conditions Conditions to avoid No particular conditions cited. Materials to avoid None cited Recommended materials No data cited for equipment Hazardous decomposition _ If decomposition occurs, acrid irritating thick black products, smoke may be emitted. TOXICOLOGICAL INFORMATION Short Term Effects Eyes Skin Ingestion Inhalation Not a primary eye irritant Not a primary skin irritant. A concentration of 12% propyl paraben i propylene glycol did not irritate the human skin whereas a 15% solut ‘was irritant. Propyl paraben LD,, oral mouse >8000 mg/kg body weight but doses of 60Ding/kg were reported fatd to dogs and rabbit. No significant toxic effect reported. Long Term Effects ‘The product has not shown any evidence in tests so far of being carcinogenic, mutagenic or toxic for reproduction. In many of the tests reviewed up to September 1988, the tests indicated no significant adverse long term effects if the product is used as intended and recommended by the manufacturer. There is considerable presumption, partially supported by the experimental findings, chat it is rapidly metabolised and excreted by Relatively rare sensitization can occur when used in pharmaceutical preparations and in cases of ingestion or injection - exacerbation of pre- existing skin complaints or by application to damaged skin is a more common sensitization cause. ECOLOGICAL INFORMATION Biodegradability Soil extracts, drain water‘and river water containing 2 variety of bacteria which grew ceadily in media containing hydroxy benzoic acid esters as sole carbon sources, suggesting these esters are not very resistant to microbial degradation. Aquatic Toxicity LC, leuciscus idus Smg/l (48 hours) - due to low water solubility the test was conducted with propyl paraben sodium salt. DISPOSAL CONSIDERATIONS Disposal through an authorised contractor to a licensed site. Bum in a licensed chemical incinerator equipped with an afterburner and scrubber. Outside the UK in accord with local regulations governingiazardous solid waste,14. TRANSPORT INFORMATION e 4 Transport Classification Not regulated ICAO/ATA/IMDG Class Transport by air (IATA) ‘Not Restricted’ ‘Transport Hezard Symbol Not required 15. REGULATORY INFORMATION Supply Classification Not Regulated. Other applicable regulations The information contained in this safety data sheet does NOT constinute a substitute for the users own assessment of risk in their workplace. 16. OTHER INFORMATION References: Chemicals (Hazard Information & Packaging) Regulations, SI 1992 No, 742, ST 1980 No. 1709, 88/379/EEC, 91/15S/EEC. IATA Dangerous Goods Regulations.1992. IMDG Code 1991 Plus amendments. ADGR Agreement 1993, Edition No, 1.1 Date of issue: 10/1/98 hy DC GODFREY Issued by: