Feature

Similarly, as shown in Figure 2, Jiangsu

Pesticides Research Institute Co. Ltd. &
Dalian Raiser Pesticides Co. Ltd. developed
two pesticides Fufenozide & butylene fipronil
both variations from the known pesticides
tebufenozide & fipronil.
Another interesting academia-industry
collaboration is shown in Figure 3. The
Institute of Chemistry in Central China
Normal University developed pesticides with
Jiangsu Sevencontinent Green Chemical
Ltd., Beijing Yoloo Bio-Technology Ltd. and
Shandong Cynda Chemical Ltd. respectively.
Some other representative examples
are shown in Figure 4, where structures of
three new pesticides developed by Sino-
Agri, Shenyang Sinochem Agrochemicals
Figure 2
& Hunan Research Institute of Chemical
Industry respectively are shown. Thus,
Fluopimomide developed by Sino-Agri9 is
a non-fumigant nematicide having roots in
another such structure i.e. Fluopyram which
was developed by Bayer earlier. A novel
acaricide based on pyrazolyl acrylonitrile
derivatives (SYP-9625) has been developed
by Sinochem Agrochemicals10. Further,
Brochlorfenapyr (HNPC-A3061) has been
developed by Hunan Research Institute
and has its roots in Chlorfenapyr which was
developed by BASF in the past.
In conclusion, Chinese Agrochemicals
moved from self-reliance to export and
has now ventured into discovery. While the
manufacturing capabilities have developed Figure 3
over several decades and has helped China
in production of pesticides, new laws are
slowly coming in to look into the sustainability
part. With respect to discovery we see the
following salient features:

·Academia-industry collaboration
·Mostly small changes in already
developed molecule & a pharma “me-too”
based approach so far (there could be a
different connotation with respect to the
meaning of the word “me-too” in pharma &
agrochemicals, and hence specifically we
have used the word in a pharma context),
however some novel structures are emerging
·Mostly for Chinese registration
although the patent is sought globally for the
new chemical entities in agrochemicals Figure 4

74 Annual Review 2019