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Definition
Chronic kidney disease is the slow loss of kidney function over time. The main
function of the kidneys is to remove wastes and excess water from the body.
Incidence
Chronic kidney disease and ESRD affect more than 2 out of every 1,000 people
in the United States.
Applied Anatomy
Risk factors & Causes
Chronic kidney disease (CKD) slowly gets worse over time. In the early stages,
there may be no symptoms. The loss of function usually takes months or years
to occur. It may be so slow that symptoms do not appear until kidney function is
less than one-tenth of normal.
The final stage of chronic kidney disease is called end-stage renal
disease (ESRD). At this stage, the kidneys are no longer able to remove enough
wastes and excess fluids from the body. The patient needs dialysis or a kidney.
Diabetes and high blood pressure are the two most common causes and
account for most cases.
Many other diseases and conditions can damage the kidneys, including:
■Autoimmune disorders (such as systemic lupus
erythematosus and scleroderma)
■Birth defects of the kidneys (such as polycystic kidney disease)
■Certain toxic chemicals
■Glomerulonephritis
■Injury or trauma
■Kidney stones and infection
■Problems with the arteries leading to or inside the kidneys
■Some pain medications and other drugs (such as cancer drugs)
■Reflux nephropathy (in which the kidneys are damaged by the backward flow
of urine)
into the kidneys
■Other kidney diseases
Symptoms
The early symptoms of chronic kidney disease are also symptoms of other
illnesses. These symptoms may be the only signs of kidney disease until the
condition is more advanced.
Symptoms may include:
■Appetite loss
■General ill feeling and fatigue
■Headaches
■Itching (pruritus) and dry skin
■Nausea
■Weight loss without trying to lose weight
Other symptoms that may develop, especially when kidney function has gotten
worse, include:
■Abnormally dark or light skin
■Bone pain
■Brain and nervous system symptoms:
■Drowsiness and confusion
■Problems concentrating or thinking
■Numbness in the hands, feet, or other areas
■Muscle twitching or cramps
■Breath odor
■Easy bruising, bleeding, or blood in the stool
■Excessive thirst
■Frequent hiccups
■Low level of sexual interest and impotence
■Menstrual periods stop (amenorrhea)
■Shortness of breath
■Sleep problems, such as insomnia, restless leg syndrome, and obstructive sleep
■apnea
■Swelling of the feet and hands (edema)
■Vomiting, typically in the morning
Pathophsiology
In response to renal injury, there is thought to be an increase in intra- glomerular
pressure with gloerular hypertrophy, as the kidney attempts to adapt to nephron
loss to maintain constant glomerular filtration
↓
Failure of renal circulation & glumerular or tubular dysfunction
↓
Damaged tubules cannot conserve sodium normally which activates rennin-
angiotensn-aldosterone system
↓
Sodium& fluid retention which leads to edema
↓
Sudden & complete loss of kidney function
↓
Reduced blood low to kidney due to renal vasoconstriction decrease the GFR &
tubular flow
↓
Oliguria
↓
Increased circulatory overload & sodium retention
↓
Acute Renal Failure
Tests that check how well the kidneys are working include:
■Creatinine clearance
■Creatinine levels
■BUN
Chronic kidney disease changes the results of several other tests. Every patient
needs to have the following checked regularly, as often as every 2 - 3 months
when kidney disease gets worse:
■Albumin
■Calcium
■Cholesterol
■Complete blood count (CBC)
■Electrolytes
■Magnesium
■Phosphorous
■Potassium
■Sodium
■Causes of chronic kidney disease may be seen on:
■Abdominal CT scan
■Abdominal MRI
■Abdominal ultrasound
■Kidney biopsy
■Kidney scan
■Kidney ultrasound
This disease may also change the results of the following tests:
■Erythropoietin
■PTH
■Bone density test
■Vitamin D
Treatment
■Controlling blood pressure will slow further kidney damage.
■Angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor
blockers (ARBs) are used most often.
■The goal is to keep blood pressure at or below 130/80 mmHg
Other tips for protecting the kidneys and preventing heart disease and
stroke:
■Do not smoke.
■Eat meals that is low in fat and cholesterol.
■Get regular exercise (talk to your doctor or nurse before starting to exercise).
■Take drugs to lower your cholesterol, if needed.
■Keep your blood sugar under control.
■Avoid eating too much salt or potassium.
■Always talk to your kidney doctor before taking any over-the-counter
medicine, vitamin, or herbal supplement. Make sure all of the doctors you visit
know you have chronic kidney disease.
Other treatments may include:
■Special medicines called phosphate binders, to help prevent phosphorous
levels from becoming too high
■Treatment for anemia, such as extra iron in the diet, iron pills, iron through a
vein (intravenous iron) special shots of a medicine called erythropoietin, and
blood transfusions
Extra calcium and vitamin D (always talk to your doctor before taking)
You may need to limit fluids.
■Your health care provider may recommend a low-protein diet.
■You may have to restrict salt, potassium, phosphorous, and other electrolytes.
■It is important to get enough calories when you are losing weight.
■Different treatments are available for problems with sleep or restless legs
syndrome.
■Everyone with chronic kidney disease should be up-to-date on important
vaccinations, including:
-H1N1 (swine flu) vaccine
-Hepatitis A vaccine
-Hepatitis B vaccine
-Influenza vaccine
-Pneumococcal polysaccharide vaccine (PPV)
■■When the loss of kidney function becomes more severe, you will need to
prepare for dialysis or a kidney transplant.
■When you start dialysis depends on different factors, including your lab test
results, severity of symptoms, and readiness.
■You should begin to prepare for dialysis before you need it. Learn about
dialysis and the types of dialysis therapies, and how a dialysis access is placed.
■Even people who are candidates for a kidney transplant may need dialysis
while waiting for a kidney to become available.
Expectations (prognosis)
Many people are not diagnosed with chronic kidney disease until they have lost
most of their kidney function.
There is no cure for chronic kidney disease. Untreated, it usually worsens
to end-stage renal disease. Lifelong treatment may control the symptoms of
chronic kidney disease.
Complications
■Anemia
■Bleeding from the stomach or intestines
■Bone, joint, and muscle pain
■Changes in blood sugar
■Damage to nerves of the legs and arms (peripheral neuropathy)
■Dementia
■Fluid buildup around the lungs (pleural effusion)
■Heart and blood vessel complications
■Congestive heart failure
■Coronary artery disease
■High blood pressure
■Pericarditis
■Stroke
■High phosphorous levels
■High potassium levels
■Hyperparathyroidism
■Increased risk of infections
■Liver damage or failure
■Malnutrition
■Miscarriages and infertility
■Seizures
■Swelling (edema)
■Weakening of the bones and increased risk of fractures
Prevention
Treating the condition that is causing the problem may help prevent or delay
chronic kidney disease. People who have diabetes should control their blood
sugar and blood pressure levels and should not smoke.
1)Fluid Volume Excess:-CRF
Renal disorder impairs glomerular filtration that resulted to fluid overload. With fluid volume excess, hydrostatic pressure is higher
than the usual pushing excess fluids into the interstitial spaces. Since fluids are not reabsorbed at the venous end, fluid volume
overloads the lymph system and stays in the interstitial spaces leading the patient to have edema, weight gain, pulmonary
congestion and HPN at the same time due to decrease GFR, nephron hypertrophied leading to decrease ability of the kidney to
concentrate urine and impaired excretion of fluid thus leading to oliguria/anuria
6. Determine 6. To know
possible underlying
pathophysiology condition that
and causes of pain leads to pain and
possible
management
that would not
further aggravate
pain.
18. Provides
19. Assist with self- divertionary
care activities. activities that
help block the
perception of
pain by the brain.
20. Assist in treatment
of underlying
disease process
causing pain. 19. To able to
perform ADL’s
21. Provide for and maintain
individualized good hygiene.
physical therapy/
exercise program
that can be
continued by the 20. Evaluate
client discharge effectiveness of
refer to physical therapies.
therapist. 21. To continue
therapeutic
effect and
22. Administer wellness for the
analgesics as patient
ordered. 22. Pharmacologic
mgmt for pain
5. Note characteristic
of urine: measure 5. To assess for
urine specific hematuria and
gravity. proteinuria and
renal
6. Ascertain usual impairment.
voiding pattern 6. To compare with
current situation.
9. Monitor BP,
ascertain patient’s 9. GFR may
usual range. increase rennin
and raise BP.
10. Observe for
dependent
generalized edema. 10. To note degree
of impairment of
11. Measure urine renal function.
output on a regular
schedule and weigh 11. To assess renal
daily. perfusion and
function.
12. Provide diet
restriction as 12. Calories to meet
indicated, while body’s need
providing adequate while restriction
calories. of protein helps
limit BUN.
13. Encourage
discussion of 13. To decrease
feelings regarding anxiety about
prognosis or long condition and
term effects of correct his
discussion. wrong ideas
about condition.
14. Identify necessary
changes in lifestyle 14. To promote
and assist client to wellness and
incorporate disease prevent further
management to progression of
ADLs. complication.
19. To establish
19. Review
expectations of the individual goals.
patient/SO.
6. Assist in 6. To control
developing underlying
individualized factors.
regimen.
7. Provide diet
modification
as indicated. 7. To establish a
nutritional plans.
8. Determine
whether
patient prefers
more calories 8. To establish a
in a meal. nutritional plans.
9. Avoid high in
sodium-rich
food. 9. To prevent
further increase
10. Promote in sodium level.
relaxing
environment. 10. To enhance
intake.
11. Provide oral
care.
11. To prevent
12. Provide safety. further spread of
dental caries.
14. Change
position every 13. To decrease
2 hours. metabolic
demand.