Practical Course in Film Coating of Pharmaceutical Dosage Forms with EUDRAGIT Preface 1. Enteric Coating of Tablets 1.1.

Introduction 1.1.1 Controlled Drug Release through Film Coatings 1.1.2 Technical Aspects of the Manufacture of Enteric Sugar-Coated Products 1.1.3 Calculation of Polymer Quantities 1.1.4 Solvents 1.2 Preparatory and Associated Work 1.2.1 Preparation of Polymer Solutions in Organic Solvents 1.2.2 Preparation of Polymer Dispersion in Water 1.2.3 Controlling the Effectiveness of the Enteric Coating Process 1.3. Examples of Enteric Coating Processes for Tablets 1.3.1 Enteric Coatings with Organic Solvents Applied by Ladling 1.3.2 Enteric Coating with Aqueous Polymer Dispersions Applied by Ladling 1.3.3 Sugar Coating of Film-Coated Cores Transition from Enteric-Coated Cores to Sugar-Coated Products 1.3.4 Enteric Spray Coating with Organic Solvents 1.3.5 Spray Application of Colored Final Coats from Organic Polymer Solutions to Enteric -Coated Cores 1.3.6 Enteric Spray Coating with Aqueous Polymer Dispersions 1.3.6 b Colored Enteric Coating of Tablets with EUDRAGIT L 30 D-55 1.3.6 c Coating of Drug Crystals in Httlin Kugelcoater HKC 5 1.3.6.d Enteric Coating of Acetylsalicylic Acid Crystals by Fluidized-Bed Process 1.3.7 Spray Application of Colored Final Coats from Aqueous Dispersions to Enteric-Coated Cores 1.3.8 Enteric Coatings with Delayed Release in the Intestinal Tract 1.3.9 Enteric Coating of Drug Capsules Using Aqueous Dispersions 2. Rapidly Disintegrating and Colored Tablet Coatings 2.1. Introduction 2.1.1 Requirements for Protective Coatings 2.1.2 Technical Aspects of the Manufacture of Rapidly Disintegrating Coatings Spray systems Airless spray systems Arrangement of spray systems and airflow in the coating pan Special coating pan designs Fluidized-bed equipment Pigments Polishing

Methods for testing film coatings 2.2. Preparatory and Associated Work 2.2.1 Preparation of the Pigment Suspensions 2.2.2 Formulations with Soluble Dyes 2.2.3 Preparation of an Aqueous Polymer Solution with EUDRAGIT E 100 for Water-Soluble Film Coatings 2.2.4 Disintegration Test in Water and Gastric Fluid 2.3. Examples of Applications for Colored Tablet Coatings 2.3.1 Spray Application of Colorless Protective Coatings with Organic Solvents 2.3.2 Spray Application of Pigmented Organic Polymer Solutions 2.3.3 Spray Application of Pigmented Aqueous Polymer Dispersions 2.3.4 Semiautomatic Spraying Processes in a Modified Coating Pan 2.3.5 Spray Application in Perforated Drums 2.3.6 Spray Application in the Accela -Cota 10 2.3.7 Tablet Coating by Means of the Fluidized-bed Process 3. Sustained-Release Dosage Forms 3.1. Introduction 3.1.1 Matrix Tablets 3.1.2 Multiparticulate Dosage Forms 3.1.3 Possible Combinations of Coating Media 3.1.4 Testing of Dosage Forms with Modified Drug Release 3.2. Preparatory and Associated Work 3.2.1 Pelletizing in the Coating Pan 3.2.2 Estimating the Surface Area of Small Particles 3.2.3 In Vitro Testing of Drug Release 3.2.4 Cleaning of Equipment after Processing EUDRAGIT 3.3 Examples of Applications 3.3.1 Manufacture of Matrix Tablets by Direct Compression 3.3.3 Compression of coated particles 3.3.4 Coating of Active Pellets with Aqueous Dispersions by Top-Spray Technique 3.3.5 Coating of Active Pellets with Aqueous Dispersions by Bottom-Spray Technique 3.3.5 b Coating of Drug Crystals by Bottom Spraying with EUDRAGIT NE 30 D 3.3.5.c Coating of Drug Pellets by Bottom Spraying with EUDRAGIT RS 30 D 3.3.5.d Coating of Drug Pellets by Bottom Spraying with colored EUDRAGIT RS 30 D 3.3.6. Coating of Drug Crystals by Tangential Spraying with EUDRAGIT NE 30 D 3.3.7 Coating of Active Granules with Dispersion Mixtures of EUDRAGIT RL 30 D and EUDRAGIT RS 30 D 3.3.7 b Coating of Drug Particles with EUDRAGIT RL 30 D/ EUDRAGIT RS 30 D 3.3.8 Sustained-Release Coating of Theophylline Granules by Fluidized Bed process