15 - April - 2018

1. Which treatment is more safely for outpatient with pulmonary embolism 


a-heparin only

b-heparin + fendaparinux

c-fendaparinux + low molecular weight heparin ✔

d-fendaparinux + heparin + low molecular weight heparin

2. Treatment of Sickle cell anemia:Hydroxyl urea✔

3. Long acting ophthalmic bb: Timilol✔

Diaphragm 1:

4. MTC mean: minimum toxic concentration ✔

5. MEC mean : minimum effective concentration ✔
6. Clinical use therapeutic range : between MTC & MEC✔
7. AUC: area under the concentration time curve✔
8. Area is measured by: Trapezoidal method✔
9. After you open an inhaler, it will be valid for:

A- 2 weeks

B- one month 

C- 3 month with proper storage✔
10. Thrombocytopenia can be overcome by:

A- fligerastime

B- oprelvekin✔
11.Patient with microcytic anemia, low RBC count, and low HB. Which
medicine can be used for ttt along with iron iron 

- Vitamin B12

- folic acid

- erythropoietin ✔
12. Semi-controlled drug:
-licensed GP can prescribe for 30 days with no refill
-specialist prescribe for 30 days with one refill
-the Rx valid duration is no more than 3 days from the date of Rx, all
-all✔
13. Semi-controlled drugs: CDB-gp 5✔
14. Pt has tb infection. The bacterium underwent mutation in the DNA of RNA
polymerase. Which drug will the bacteria be resistant to; rifampicin✔
15. Estrogen used in menopause women; ethenylestradiol✔
16. A drug that has high risk for thrombosis and MI; celecoxib ✔
17. Phenoxybenzamine is which type of antagonist: irreversible antagonist✔
18. Where is gastrich histamin stored in the GIT: Entrochromaffin-like- cell✔
19.Nephroprotective immune suppressant

-tacrolimus

-sirolimus✔

-azathioprine
20. Which is most likely to cause rash: (PLEASE CHECK)

- Amoxicillin ✔
- Ampicillin
- Penicillin G
21. Histamine autoreceptor: H3✔
22. Skeletal & adioose tissue glucose transporter: Glut4✔
23. Which of these is used in anaemia:

- Iron

- Erythropiotein
- Folic acid
- Vit. B12 (cyanocobalamine)
- ALL✔
24. Which of the following is used in athlete’s foot:

- Clotrimazole 

- Griseofluvin 

- Nystatin

- 1&2✔

- 2&3

- 1,2&3
25. Antiphologsitcs act by: Cooling by evaporation ✔
26. INR,amoidarone & MTX common side effects:

- Heart faliure

- Cirrhosis of the liver✔ 

- Pancytopenia

- Pulmonary problem
27. Temperature changes are avoided in emuslions to prevent: Cracking✔
28. Oil droplets on the surface of emulsion. Homogenous upon shaking:
Creaming✔
29. Two hydrophobic molecules with opposite charges mixed with water:
Emulsification✔
30. Digoxin acts on: Na/k atpase ✔
31. Digoxin CI in:

- Complete heart block✔ 

- Venticular arrythmia
32. Bethanicol used in all except:

- GERD

- Sjorjen’s syndrome✔

- Post head & neck surgery
33. Patient has shigella with fever and mucus and blood in stool. Which
antimicrobial is used:

- Non antibacterial treatment
- Norfloxacin✔
34. Which antibiotic is used for 3 days single dose for ear, nose & throat
infection: Azithromycin✔
35. Drug is most likely to cause pseudomembranous colitis: Clindamycin✔
36. Bacteria most likely to cause pseudomembranous colitis: Clostridium
difficle✔
37. Drug of choice for pseudomembranous colitis:

- Vancomycin

- Metronidazole✔
38. Patient was using pilocarpine for 3 years without medical supervision;
suddenly experienced loss of breath. Managment?

- Epinephrine✔ 

- Norepinephrine

- Atropine
39. Which anticancer acts on the M phase: Vinblastine ✔
40. Alternative to vinblastine: Paclitaxel✔
41. Which anticancer is least immunosuppressive: Bleomycin✔
42. Which anticancer cause dry cough and rales: Bleomycin✔
43. Dobutamine infusion action: Interacting directly with beta & alpha
receptors✔
44. Most appropriate treatment for oliguria with MTX therapy: Hydration✔
45. Which supplement is to be used with MTX:

- Folic acid

- Folnic acid✔
46. Which side effect is not reversed by levourcin: Hepatotoxicity✔
47. Diabetic neuropathy is a: Microvascular complication✔
48. Protamine suplhate is antidote for all except: Fondaprinux✔
49. Which AcEI is not renally excerted: Fosinopril✔
50. Hosptalized patient with angina and severe hypertension. Antihypertensive
suitable for him is:

-metoprolol✔

-hydralazine

-methyldopa

-clonidine
51. Which drug can counteract the increased risk of angina caused by the use of
hydralazine for this patient:

-nitroglycerin✔

-nifedipine
52. Patient on hydrochlorothiazide that was not effective. Additional
antihypertensive which rapidly decreased blood presssure in first 2 hours:

-atenolol✔

-ACEI

-CcB
53. Which of these used in emergency htn and causes prompt hypotensive effect:

- Sodium nitroprusside ✔
54. Drug is used in amoebiasis with asymptomatic cysts: 

- diloxanide✔

- emetin
55. Patient with renal transplant and chronic gout, most suitable ttt:

-allopurinol✔

-colchicine
56. Anaesthia for pt with cardiac problem: Fentanyl✔
57. Anaesthesia for patient with severe psychosis: Methohexital✔
58. Pt. experiences migraines 4-5 x a month. Most suitable migraine
prophylaxis:

Propranolol✔
59. Patient with HIB infection after 6 month of needle exposure. Least effective
ttt: HBV Vaccine✔
60. Which of these causes life-threatening hyperkalemia: Spironolactone✔
61. Which is a pure antagonist with no intrinsic sympathomimetic effect:

- Propranolol✔

- Acebutalol

- Pindolol
62. Atropine causes all of the following except: Pupil constriction ✔
63. Leprosy treatment resistance is due to: 

- treatment with one drug

- lepromatous leprosy

- inherent resistance
- All of the above✔
64. All of the following are drugs that promotes hyperglycemia in DM except:

- NSAIDs✔ 

- nicotinic acid

- diuretic

- opioids
65. Not used for atrial fibrillation:

- quinidine, 

- lidocaine ✔

- procainamide, 

- flecaninde
66. Pt taking botox injection in her face, SE: respiratory paralysis✔
67.Vancomycin red man syndrome caused by stimulate release of : Histamine✔
68. Generic drug is:
- Chemical name
- Drug not under protection of originator ✔
- Drug not manufactured by the originator ✔

69. All are SE of desipramine except: Bradycardia ✔

70. All of the following are NOT activate receptors except : (so he want active
receptor)

- Chlosgramine

- AlOH

- Mannitol

- Neostigmine ✔
71. Treatment for exacerbation of ulcerative colitis: Prednisolone ✔
72. Acidic drug carrier in plasma: Albumin ✔
73. Pt with COPD and heart failure, which to avoid:-
- Nicardipine
- Amiodarone ✔
74. Faciliated diffusion: Down conc. gradient, pgylcoprotein in intrinsic cells,
and requires transport ✔
75. Medications can be sold as:

- Original Packet

- packet with the name of the drug, batch no., and expiry

- packet with a copy of the patient leaflet

- ALL ✔
76. For tablet preparation, all of the following can be used except :

- Wet granulation method

- Dry granulation method

- Direct Compressing

- Indirect compressing ✔
77. All can be used in aqueous typical tablet coating except: Volatile substance ✔

78. Patient with glaucoma taking ectothiophate, what is the reoccurring side
effect?

- Tonic pupil

- Cataract ✔
79. Controlled drug:
-licensed GP can prescript for only 3 days
- refill must not be issued for control medicine
-duration of Rx to be dispense is no more than 2 days from the date of Rx
-all of the above ✔
80. AntiTB drug least likely to cause urine discolouration: Ethambutol ✔
81. Pharmaceutical equivalents EXCEPT: rate and extent of bioavailability ✔
82. Titanium Dioxide used in sunscreen to:

- Reflect the UV ✔

- Absorb the UV

- Humectants agent
83. Drug that does not enhance the action of sulfonylurea: Diazoxide ✔
 84. Which of the following non-mast cells does not secrete histamine:
Subcutaneous fatty tissue (adipose tissue) ✔
85. Two drugs were given together. Their effect is equal to the sum of their action.
This is called: (PLEASE CHECK)
- Potentiation
- Synergism ✔
- Antagonism
86. Which tablets do not need a disintegrating or lubricating agent: Effervescent
tablets ✔
87. Refrigerator temperature: 2 - 8 ✔
88. Which of the following needs hydrolysis of ATP: 1ry active transport ✔
89. With malathion poisoning, enzyme involved is: Acetylcholine esterase ✔
90. Controlled release drugs are all of the following except: less expensive ✔
91. Which statement is true about sumatriptan: (PLEASE CHECK)
- 2 statements about it being a serotonin antagonist —> false
- Recurrence of the headache after administration is common
- Coronary artery disease is a relative contraindication, less nausea
symptoms than with dihydroergotamine, recurrence of headache is common ✔

Diagram 2:

92. T max of IV curve: 0 hr ✔

93. Tmax of oral curve: 4 hr ✔
94. Assume zero order for iv curve what will be the t half: 12 hr ✔
95. The colored area reflect: AUC ✔
96. Which is true: Onset of IV is faster than oral ✔
97. Patient dose is 1.2 mg/kg. What is the proper dose for a patient weighing
27kg?
32 mg ✔
98. Patient taking an infusion of 200mg/500ml at a rate of 0.5 mg/ml. What is the
concentration in micrograms/ml?
400 mcg/ml ✔
99. How much NaCl should be mixed with 1 ml 1:1000 to convert to 1:2500?
1.5 ml ✔

Best of luck to you all!