5/17/22, 9:37 PM Effectiveness of Curcuma longa extract versus placebo for the treatment of knee osteoarthritis: A systematic review

tematic review and meta…

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REVIEW

Effectiveness of Curcuma longa extract versus placebo for the treatment of

knee osteoarthritis: A systematic review and meta-analysis of randomized
controlled trials

Wenli Dai, Wenqiang Yan, Xi Leng, Jing Chen, Xiaoqing Hu, Yingfang Ao 

First published: 02 July 2021

https://doi.org/10.1002/ptr.7204

Wenli Dai and Wenqiang Yan contributed equally to this study.

Funding information: Beijing Natural Science Foundation, Grant/Award Numbers: 7171014, 7174361,
7182175; Beijing Municipal Science and Technology Commission, Grant/Award Number:
Z171100001017085; National Natural Science Foundation of China, Grant/Award Numbers: 81672212,
81802153, 81902205

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Abstract
The aim of this systematic review was to evaluate the efficacy and safety of all types of
Curcuma longa extract versus placebo for knee osteoarthritis (OA) treatment. The
research was conducted by using the databases of PubMed, Embase, Scopus, and
Cochrane Library through April 2021. Randomized controlled trials (RCTs) that compared
the effect of Curcuma longa extract with placebo for patients with knee OA were
considered eligible. The pooled results were expressed as mean differences or relative
risks with 95% confidence intervals. A total of 10 RCTs with 783 patients were eligible for
this meta-analysis. The pooled analysis showed that Curcuma longa extract was
associated with significantly better pain relief and functional improvement compared
with placebo for knee OA. Moreover, the smallest effect sizes of VAS for pain and
WOMAC total score exceeded the minimum clinically important differences (MCIDs).
Current evidence indicates that, compared with placebo, Curcuma longa extract has more
benefit in pain relief and functional improvement for symptomatic knee OA. However,
considering the potential heterogeneity in the included studies, more future high-quality
RCTs with large sample sizes are necessary to confirm the benefits of Curcuma longa
extract on knee OA.

Open Research 

DATA AVAILABILITY STATEMENT

https://onlinelibrary.wiley.com/doi/epdf/10.1002/ptr.7204 2/4