Evaluation of Disease-Associated Text-Mining Databases

Myeong-Sang Yu Dokyun Na
Chung-Ang University Chung-Ang University
School of integrative engineering School of integrative engineering
Seoul, Korea Seoul, Korea
+82-2-820-5690 +82-2-820-5690
msirang@ssbio.cau.ac.kr blisszen@cau.ac.kr

ABSTRACT
There are about 20 million scientific articles in PubMed and this
is a great source of knowledge. Extraction of information from the
articles is one of challenges in biology and thus many text-mining
approaches have been developed. However, the accuracy of text-
mined results is still in question. Here we evaluated three text-
mining databases with genes associated with Alzheimer’s disease.
Their per-gene accuracy is high (57-100%), but their per-abstract
accuracy is relatively low (33-64%). This represents that the
association of gene and disease is well-identified when abundant
articles are available. However, genes with fewer articles could be
wrongfully identified associated. Consequently, human-curation is
still complementary to current text-mining approaches and future
text-mining methods should improve their accuracy for genes with
few articles or information.

Categories and Subject Descriptors

J.3 [Life and medical science]: Medical information system

Keywords
Text mining; Database; Alzheimer’s disease

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DTMBIO'15, October 23, 2015, Melbourne, VIC, Australia.
ACM 978-1-4503-3787-8/15/10.
DOI: http://dx.doi.org/10.1145/2811163.2811169

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