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` Research article
Dennie van den Noort 1, Emmeline Oltmans 1, Haruhito Aoki 2,3, Gino M.M.J. Kerkhoffs 1,4,5 and Vincent
Gouttebarge 1,4,5,6,7
1
Amsterdam UMC, University of Amsterdam, Department of Orthopaedic Surgery, Amsterdam Movement Sciences,
Meibergdreef 9, Amsterdam, the Netherlands; 2 St. Marianna University School of Medicine, Kawasaki, Japan; 3
Yokohama City Sports Medical Center, Yokohama, Japan; 4 Academic Center for Evidence based Sports medicine
(ACES), Amsterdam, the Netherlands; 5 Amsterdam Collaboration on Health & Safety in Sports (ACHSS), Amsterdam
UMC IOC Research Center of Excellence, Amsterdam, the Netherlands, 6 Division of Exercise Science and Sports
Medicine, University of Cape Town, Cape Town, South Africa; 7 FIFPRO (Football Players Worldwide), Hoofddorp, the
Netherlands
Most of above-mentioned findings, however, are bias. Suitable matched controls received information and
based on overall OA of the lower limb. Similar information were asked to fill in the same questionnaires.
regarding the prevalence and consequences of hip OA in
professional footballers is scarce. Such epidemiological Outcome measures
information is needed in order to define strategies for the We used the NICE criteria (adapted for age) to define OA,
prevention of the condition, as well as for the development which was described as the joint’s cartilage damage that
of support measures for players. Consequently, the leads to activity-related pain of the joint with either
objectives of this study were to establish the prevalence of morning stiffness that is less than 30 minutes long or no
clinical hip OA in current and former professional morning joint-related stiffness (National Clinical
footballers and to explore its consequences on hip function Guideline, 2014). Information about the presence of
and HRQoL. Three research questions were formulated, clinically diagnosed hip OA was retrieved by asking a
namely: (1) What is the prevalence of clinical hip OA in single question (‘Have you been diagnosed with
current and former professional footballers? (2) What is the osteoarthritis in the hips by a medical professional?’). To
hip function in current and former professional footballers answer this question, participants were asked to consult
with and without clinical hip OA and how does this either their physician or their medical record.
compare to a control group of non-elite athletes? (3) What Hip related impaired activities and pain were
is the level of HRQoL in current and former professional assessed by using the Hip dysfunction and Osteoarthritis
footballers with and without clinical hip OA and how does Outcome Score Shortform (HOOS-PS) (Lyman et al.,
this compare to a control group of non-elite athletes? 2016; Nilsdotter et al., 2003). Six items were measured on
a 5-point scale and subsequently converted to a total score
from 0 to 100, where 0 represents total disability of the hip
Methods
and a score of 100 represents perfect health of the hip
(Nilsdotter et al., 2003). To inquire about HRQoL, the
Design Patient-Reported Outcomes Measurement Information
We conducted a cross-sectional study by means of System Global Health short form (PROMIS-GH) was used
questionnaire, using of the statement from “Strengthening (Hays et al., 2009). Using 10 items scored on a 5-point
the Reporting of Observational Studies in Epidemiology” scale, the Global Mental health and Global Physical Health
to ensure the quality of our report (Vandenbroucke et al., scores were calculated (Hays et al., 2009). Both scores
2014). The study was given ethical approval by the ranged from 0 to 100, with a lower score indicating a worse
Medical Ethics Review Committee of the Academic quality of life and the mean score of 50 indicating the
Medical Center (W16_366#16.431). The study was standard in the general population (Hays et al., 2009). We
conducted in accordance with the Declaration of Helsinki chose the HOOS-PS and the PROMIS-GH because they
(2013). have been validated in multiple study populations and
different languages among those French, English and
Study participants Spanish (Hays et al., 2009; Lyman et al., 2016; Nilsdotter
Study participants were current and former professional et al., 2003).
footballers. Our definition for a current or former
professional footballer was that: (1) he trains or has trained Procedures
to improve football performances (2) he competes or has Using LimeSurvey professional (LimeSurvey GmbH,
competed in one of the two highest national leagues in his Hamburg, Germany), we compiled a digital anonymous
country (3) competition and training are or were a main questionnaire available in French, English and Spanish.
occupational activity. A player was eligible if: (1) male (2) This questionnaire included the following descriptive
active or retired professional footballer (3) member of variables: age, height, body-weight, duration of
FIFPRO (Football Players Worldwide) (4) between 18 and professional football career, level of play, nature and
50 years old (5) able to read and understand texts in French, duration of retirement, level of education, and current
Spanish, or English. Assuming an anticipated population employment status. FIFPRO’s administration sent
proportion of 20% for hip OA (objective 1), a sample size information about the study to potential participants. All
was calculated indicating the need of 196 participants in participants gave their electronic informed consent and
each study group (power of 80%, confidence interval of filled in the questionnaire (within 2 weeks, reminders being
95%; absolute precision of 5%). (Woodward, 2014) As we sent after 2 and 4 weeks). Contribution to the study was
expected a response rate of around 30% (indicated by done voluntarily and no reward was given for participating.
previous studies in professional athletes), we aimed to
reach at least 1300 participants (650 per group) Statistical analyses
(Gouttebarge et al., 2016; Schuring et al., 2016). Data analyses were conducted with IBM SPSS statistics
26. By using height and weight, Body mass index (BMI)
Matched controls was calculated in kgꞏm-2. For all variables included in the
Participants were asked to find one control from their non- study a descriptive data analysis (e.g., standard deviation
elite sport network who were comparable in the following (SD), mean, frequency, median) was performed. The
variables: gender, age, body weight and height. The proportion of the number of participants with hip OA
matching was done to reduce risk of pattern and selection compared to the total number of participants was used to
286 Hip OA, HRQoL and hip function in professional footballers
calculate the prevalence of hip OA (percentages), using the hip OA in former professional footballers than in current
Wald method for the calculation of 95% confidence professional footballers (X² = 23.23; df = 1; p ≤ 0.001).
interval (CI) (Woodward, 2014). The Chi-square test was
used to calculate the difference in prevalence between Hip function
current and former professional football players Both current and former professional footballers with hip
(Woodward, 2014). The level of hip function and HRQoL OA reported a lower HOOS-PS score than players without
were both descriptively analyzed in the group of hip OA. A mean score of 74.4 was reported by current
participants (both with and without hip OA) and in the professional footballers with hip OA while current players
group of matched controls. The Kolmogorov-Smirnov test without hip OA reported a mean of 92.7 (Mann-Whitney
and Mann-Whitney test (independent samples) was used to test: U = 3614; Z = 5.64; p ≤ 0.001). Former professional
determine normal distribution and make comparisons footballers with hip OA reported a mean HOOS-PS 56.6
between groups, respectively (Woodward, 2014). A cut off while those without hip OA reported a mean of 92.9
value of p < 0,05 for significance was chosen. (Mann-Whitney test U = 722.7; Z = 9.03; p ≤ 0.01). The
control group reported a mean HOOS-PS score of 91.2 (SD
Privacy and confidentiality 14.5). The footballers with hip OA reported significant
Potential participants were recruited with blinding of the lower scores of the HOOS-PS than the control group: 74.4
principal investigator. The anonymous questionnaires (Mann-Whitney test U = 243.5; Z = 3.68; p ≤ 0.001) for the
ensured privacy and confidentiality. Questionnaires were current and 56.6 (Mann-Whitney test U = 139; Z = 6.25; p
stored on a secured electronic server to which only the ≤ 0.001) for the former professional footballers. The
principal investigator had access. HOOS-PS scores of both current and former footballers
without hip OA were similar to the scores reported in the
Results control group. All data about hip function are presented in
Table 2.
Participants Health-related quality of life
From the 2500 current and former professional footballers Current professional footballers with hip OA reported
that were contacted, there were 1,401 players who gave mean scores of 47.7 and 50.0 for the physical and mental
informed consent and filled in the questionnaires (1,000 health components, respectively. Those without hip OA
current and 401 former professional footballers). A total of reported higher scores: 50.8 (Mann-Whitney test U = 6739;
52 controls were recruited. In current professional Z = 2.14; p = 0.032) and 51.2 (Mann-Whitney test U =
footballers the mean age was 26.1 (SD 4.5) years with an 9500.5; Z = 0.19; p = 0.853) for the physical and mental
average career duration of 7.3 (SD 4.4) years. The mean health scores components, respectively. Former
age of retired players was 36.5 (SD 5.5) years with an professional footballers with hip OA reported mean scores
average career duration of 11.3 (SD 4.7) years. All of 47.7 and 48.9 for the physical and mental health
characteristics of the participants are presented in Table 1. components, respectively. Those without hip OA reported
higher scores: 51.3 (Mann-Whitney test U = 3539; Z =
Hip osteoarthritis 3.04; p = 0.002) and 51.7 (Mann-Whitney test U = 4391; Z
Prevalence of hip OA was 2% (95% CI 1.6-3.6) among = 1.54; p = 0.124) for the physical and mental components,
current professional footballers. The prevalence among respectively. See Figure 1 for a visual representation of the
former professional footballers was 8% (95% CI 5.7-11.1). physical and mental scores in current and former
Comparison showed a significantly higher prevalence of professional footballers with and without hip OA.
Table 2. Outcome measures. *hip dysfunction and osteoarthritis outcome score shortform.
Current (n = 1000) Former (n = 401) Control
Outcomes Total No hip OA With hip OA Total No hip OA With hip OA (n = 52)
HOOS-PS total score (mean ± SD) 92.3 ± 13.7 92.7 ± 13.4 74.4 ± 16.2 90.3 ± 17.2 92.9 ± 13.5 56.6 ± 20.5 91.2 ± 14.5
Physical health (mean ± SD) 50.7 ± 7.3 50.8 ± 7.3 47.7 ± 5.9 51.0 ± 7.6 51.3 ± 7.6 47.7 ± 6.7 53.1 ± 9.1
Mental health (mean ± SD) 51.2 ± 7.4 51.2 ± 7.4 50.0 ± 9.2 51.5 ± 8.1 51.7 ± 8.0 48.9 ± 9.1 53.8 ± 7.3
HOOS-PS = hip dysfunction and osteoarthritis outcome score shortform.
Figure 1. Physical and mental health with and without hip osteoarthritis. With the general US population as reference.
The control group reported mean scores of 53.1 and lower in both current and former professional footballers
53.8 for the physical and mental health components, with hip OA than in those without hip OA or in the control
respectively. The current professional players with hip OA group; (3) former and current professional footballers with
reported a significantly lower physical health score 47.7 hip OA reported significantly lower physical health scores
(Mann-Whitney test U = 322; Z = 2.51; p = 0.012) than those without hip OA; (4) hip OA led to a significantly
compared to the control group but not a significant lower lower score in both components of HRQoL in former
mental health score 50.0 (Mann-Whitney test U = 436; Z = professional footballers when compared to the controls,
1.07; p = 0.286). The current professional footballers while in current professional footballers only the physical
without hip OA reported a significantly lower mental component was significantly lower compared to the
health score 51.2 (Mann-Whitney test U = 1804.5; Z = controls.
1.97; p = 0.049) when compared to the control group. The
current professional footballers without hip OA did not Perspective of the findings
report a lower physical health score (Mann-Whitney test U Hip OA is a common problem in the general male
= 1815.5; Z = 1.92; p = 0.055) when compared to the population with prevalence ranging from 0.3% to 8.3%
control group. Former professional footballers with hip OA (age >19) (Guillemin et al., 2011). A lot of variance is seen
reported significantly lower scores both in the physical in prevalence of hip OA because of the definition used and
47.7 (Mann-Whitney test U = 462.5; Z = 2.9; p = 0.004) whether radiological imaging is used or not for diagnosis
and mental 48.9 (Mann-Whitney test U = 506.5; Z = 2.46; (Parsons et al., 2015). In our study, the prevalence of
p = 0.014) components. The former professional clinical hip OA was around 2% among current players and
footballers without hip OA showed no significant around 8% among former professional footballers. We
difference compared to the controls. The total mean of both know, however, that prevalence of OA rises with age
the physical and mental components and the standard (Lespasio et al., 2018; Quintana et al., 2008). Therefore,
deviations are presented in Table 2. we decided to run a post hoc analysis by splitting arbitrarily
both current and former professional footballer into three
Discussion different age groups. Among current professional
footballers, prevalence of hip OA was 1%, 3% and 5% for
The main findings of our study were: (1) prevalence of hip the age groups 18-24 years, 24-30 years and >30 years,
OA was 2% among current and 8% among former respectively. Former professional footballers showed a
professional footballers; (2) hip function was significantly prevalence of hip OA of 8%, 8% and 10% for the age
288 Hip OA, HRQoL and hip function in professional footballers
groups <35 years, 35-40 years and >40 years, respectively. examined at the time of the questionnaire combined with
Our results confirm that prevalence of hip OA increases radiological imaging; however, due to a large and spread
with age, and that the condition is already present among out sample size, this was not possible.
current professional footballers.
Former professional football players report a Recommendations
prevalence of hip arthroplasty ranging from 8.9% to 13.5% Based on our findings, we advise that there should be more
compared to controls ranging from 0% to 3.8% (Lohkamp attention for hip OA and the associated negative effects.
et al., 2017; Volpi et al., 2019). This could be expected due Current professional footballers should be guided by the
to higher prevalence of hip OA and hip arthroplasty being medical teams of their respective clubs. This guidance
the main treatment for symptomatic hip OA if non-surgical should focus on the prevention of recurrent injuries, while
options were without success (Lespasio et al., 2018). players should also be informed about the consequences
Literature shows that other sports are associated that may arise after playing professional football for
with hip OA. Elite handball has shown a prevalence of hip multiple years, with the focus on effects after retirement.
OA up to 60% (Vigdorchik et al., 2017). A higher Former professional footballers should prevent
prevalence of hip OA is also seen among other impact deterioration of the condition with focus on pain relief,
sports and skiing at the highest level with prevalence minimizing disability and keeping the joint as mobile as
ranging from 3% up to 58% (Iosifidis et al., 2015; possible. Also, the After Career Consultation developed by
Vigdorchik et al., 2017). FIFPRO might help players during retirement with the
Development of knee and ankle OA is associated focus on sustainable HRQoL (Gouttebarge et al., 2018c).
with previous injury of the joint (Gouttebarge et al., 2018a; The After Career Consultation manages this by focusing on
Paget et al., 2020). In the hip, no such association has been five main domains; (1) helping players detrain from
found (Vigdorchik et al., 2017). A link between hip/groin professional play; (2) encouraging a healthy lifestyle; (3)
symptoms and a decrease in hip function has, however, focusing on education and employment; (4) remission of
been found (Tak et al., 2016). OA; (5) and preventing cognitive and mental health
In current players, we observed that players without problems (Gouttebarge et al., 2018c).
hip OA reported a lower mental component score than our Furthermore, to prove causation and explore the
control group (having a higher BMI), while players with course of OA, a longitudinal study was launched on
OA did not report a significantly lower score. This might October 2019 in order to track players between the ages of
be explained by two factors: 1) our control group reported 28 to 38 during and also after their careers (Gouttebarge et
a mean mental component score of 53.8, while the general al., 2019). Data collection on various health domains
population average is at 50, so our controls scored above among which OA could help us gain more insight into both
average; 2) due to a large number of current players the physical and mental health of players and how certain
without hip OA, small differences can be significant (Hays influences (retirement, injuries, etc.) might affect this. This
et al., 2009). Professional footballers with hip OA reported information could be used to develop measures both
a significant lower score for the physical component of preventive and curative to attain a high level of both
HRQoL compared to professional footballers without, this physical and mental health.
is in accordance with earlier studies (Gouttebarge et al.,
2018b). The PROMIS method for measuring HRQoL used Conclusion
the US general population as a reference, leading to a score
with a mean of 50. So when compared to the general Hip osteoarthritis has a higher prevalence in former than in
population, our study shows that current footballers with current professional footballers and impacts hip function
hip OA score lower than average on only the physical and HRQoL negatively.
component and former footballers with hip OA score lower Acknowledgements
in both components. The experiments comply with the current laws of the country in which
they were performed. The authors have no conflict of interest to declare.
Methodological considerations The datasets generated during and/or analyzed during the current study
There are a few limitations to our study. First, it was a are not publicly available, but are available from the corresponding author
who was an organizer of the study.
cross-sectional study, so we can show that current and
former professional players with hip OA, have a lower hip References
function and lower physical health scores, but our research
cannot prove a direct causal relation. Second, because Alentorn-Geli, E., Samuelsson, K., Musahl, V., Green, C.L., Bhandari, M.
recruitment procedure was blinded, performing a non- and Karlsson, J. (2017) The Association of Recreational and
Competitive Running With Hip and Knee Osteoarthritis: A
response analysis was not possible. Since a response rate Systematic Review and Meta-analysis. Journal of Orthopaedic
of 56% was achieved with 1,401 current and former & Sports Physical Therapy 47, 373-390.
professional footballers, we deem that potential bias was https://doi.org/10.2519/jospt.2017.7137
avoided and that these results are representative for this Andersen, L.B., Schnohr, P., Schroll, M. and Hein, H.O. (2000) All-Cause
Mortality Associated With Physical Activity During Leisure
population. Third, as in every scientific research, Time, Work, Sports, and Cycling to Work. Archives of Internal
participation was voluntary. This could lead to Medicine 160, 1621-1628.
participation bias because participants with interest in hip https://doi.org/10.1001/archinte.160.11.1621
OA might be more likely to participate. Fourth, clinical hip Gouttebarge, V., Andersen, T.E., Cowie, C., Goedhart, E., Jorstad, H.,
Kemp, S., Königs, M., Maas, M., Orhant, E., Rantanen, J., Salo,
OA was diagnosed by a medical professional. The ideal J., Serratosa, L., Stokes, K., Tol, J.L., Verhagen, E., Weber, A.
method would be to have all participants clinically
Van den Noort et al. 289
Vandenbroucke, J.P., von Elm, E., Altman, D.G., Gotzsche, P.C., AUTHOR BIOGRAPHY
Mulrow, C.D., Pocock, S.J., Poole, C., Schlesselman, J.J., Egger, Dennie van den NOORT
M. and Initiative, S. (2014) Strengthening the Reporting of Employment
Observational Studies in Epidemiology (STROBE): explanation
and elaboration. International Journal of Surgery 12, 1500-1524. University of Amsterdam,
https://doi.org/10.1016/j.ijsu.2014.07.014 Department of Orthopaedic Surgery.
Vigdorchik, J.M., Nepple, J.J., Eftekhary, N., Leunig, M. and Clohisy, Degree
J.C. (2017) What Is the Association of Elite Sporting Activities MD
With the Development of Hip Osteoarthritis? American Journal Research interests
of Sports Medicine 45, 961-964. Orthopaedics and sports medicine.
https://doi.org/10.1177/0363546516656359
Volpi, P., Quaglia, A., Carimati, G., Petrillo, S. and Bisciotti, G.N. (2019)
E-mail: d.vandennoort@gmail.com
High incidence of hip and knee arthroplasty in former Emmeline OLTMANS
professional, male football players. The Journal of Sports Employment
Medicine And Physical Fitness 59, 1558-1563. Medical student at the University of
https://doi.org/10.23736/S0022-4707.18.08962-4 Amsterdam
Woodward, M. (2014) Epidemiology : study design and data analysis. Degree
Boca Raton: CRC Press. BSc
Research interests
Rehabilitation medicine, sports
Key points medicine, and mental health.
E-mail: E.r.oltmans@amsterdamumc.nl
Prevalence of hip OA is 2% among current and 8% Haruhito AOKI
among former professional footballers. Employment
Professor of Orthopaedic Surgery, St.
Hip function is significantly lower in both current
Marianna University School of
and former professional footballers with hip OA Medicine, Japan
than in those without hip OA. Degree
Former and current professional footballers with hip MD, PhD
OA report significantly lower physical health scores Research interests
than those without hip OA. Sports traumatology, Sports medicine.
E-mail: haruhito@pj8.so-net.ne.jp
Gino M.M.J. KERKHOFFS
Employment
Prof., Academic Center for Evidence
based Sports medicine (ACES),
Amsterdam, the Netherlands
Degree
MD, PhD
Research interests
Sports and exercise in patient care, as well
as training, competition and health care of
adolescent athletes.
E-mail:
g.m.kerkhoffs@amsterdamumc.nl
Vincent GOUTTEBARGE
Employment
Amsterdam University Medical Centers
and FIFPRO (Football Players
Worldwide)
Degree
MSc, PhD
Research interests
Sports medicine, with a focus on active
and retired professional athletes.
E-mail: v.gouttebarge@fifpro.org