Professional Documents
Culture Documents
INFECTIOUS SUBSTANCES
and DRY ICE
v22.0
COPYRIGHT NOTICE
Class 1 - Explosives
1.1 Mass explosion hazard
1.2 Projectile but no mass explosion hazard
1.3 Fire hazard and either minor blast hazard
or minor projection hazard or both, but
not mass explosion
1.4 Minor explosion hazard and largely
confined to the package
1.5 Very insensitive explosives
1.6 Extremely insensitive articles with no
mass explosion hazard
Class 2 - Gases
2.1 Flammable gas
2.2 Nonflammable gas
2.3 Poison gas
Class 6 - Poisons
6.1 Toxics (Poisons)
6.2 Medical Waste
Infectious or Biological
Substances
GENERAL AWARENESS / APPLICABILITY
Hazard classes and divisions
Class 7 - Radioactive
7 Radioactive
Class 8 - Corrosive
8 Corrosive materials
Column 1- “G” - Technical name(s) required in parentheses following the proper shipping name
Column 7- details for the special provisions assigned to an entry are in §172.102
Column 8A- exceptions to the standard non-bulk packaging requirements (least restrictive)
Column 8B- location of packaging requirements for non-bulk packagings
Column 8C- location of packaging requirements for bulk packagings
INFECTIOUS SUBSTANCES
49 CFR – §172.102 Special provisions
Apply to air transport only:
A82 The quantity limits when transporting by aircraft do not apply to human or
animal body parts, whole organs or whole bodies known to contain or
suspected of containing an infectious substance.
Apply to all modes of transport:
When a letter does not proceed a special provision number it applies
regardless of the mode of transport or the packing group assigned unless the
content of the provision states otherwise.
INFECTIOUS SUBSTANCES
IATA – List of Dangerous Goods
Cargo Aircraft
Passenger and Cargo Aircraft
Only
Class Ltd Qty
or
Div. EQ S.P.
UN/ ID Proper Shipping (Sub. Hazard P See Pkg Max Net Pkg Max Net Pkg Max Net See ERG
No Name/Description Risk) Label G 2.6 Inst Qty/Pkg Inst Qty/Pkg Inst Qty/Pkg 4.4 Code
A B C D E F G H I J K L M N
3373 Biological substance, 6.2 E0 Forbidden See 650 See 650 11L
Category B
2900 Infectious substance, 6.2 Infectious E0 Forbidden 620 50 mL 620 4L A81 11Y
affecting animals substance A140
only (liquid)
2900 Infectious substance, 6.2 Infectious E0 620 50 g 620 4 kg A81 11Y
Forbidden
affecting animals substance A140
only (solid)
2814 Infectious substance, 6.2 Infectious E0 Forbidden 620 50 mL 620 4L A81 11Y
affecting humans substance A140
(liquid)
2814 Infectious substance, 6.2 Infectious E0 Forbidden 620 50 g 620 4 kg A81 11Y
affecting humans substance A140
(solid)
Column B- - Technical name(s) required in parentheses following the proper shipping name
Columns I & K- locations of packing instructions
Column M- details for the special provisions assigned to an entry are in 4.4
INFECTIOUS SUBSTANCES
IATA – 4.4 Special provisions
A81 The quantity limits shown in Columns J and L do not apply to body
parts, organs or whole bodies.
• Transport according to A81 must be noted on the Shipper’s
Declaration for Dangerous Goods when applying this special
provision.
Note: Blood, urine and other body fluids are not considered “body parts” for
the purpose of this special provision
A140 Eliminates the need to provide technical names with the proper
shipping name on the package
INFECTIOUS SUBSTANCES
Key terms – Division 6.2 Infectious substances
Infectious substances – a material known or reasonably expected to contain
a pathogen
Pathogen - a micro-organism that can cause disease in humans or animals
(bacteria, viruses, parasites, fungi, or other agents such as a prions)
Biological products – according to transportation regulations are either:
• Those derived from living organisms used either to prevent, treat or
diagnosis disease in humans or animals, or used in associated
development, experimental or investigative processes
➢ Manufactured and distributed according to national authority
requirements (in U.S. according to 42 U.S.C. 262 or 21 U.S.C. 151-159);
or
• Those known or reasonably expected to contain Category A or
Category B infectious substances, but which do not meet the conditions
of the previous group
➢ Classified according to transportation regulations as UN2814,
UN2900 or UN3373
INFECTIOUS SUBSTANCES
Class 6, Division 6.2 - Infectious substance
Infectious substances must be classified in Division 6.2 and assigned to the
appropriate category.
• Category A (includes a Division 6.1 plant, animal or bacterial toxin
when it contains or is contained in an infectious substance)
➢ UN2814
➢ UN2900
• Category B
➢ UN3373
Note: A genetically modified material that does not meet the definition of a
toxic or infectious substance must be assigned to UN3245
INFECTIOUS SUBSTANCES
What is a Category A infectious substance?
An infectious substance transported in a form capable of causing permanent
disability or life-threatening or fatal disease in otherwise healthy humans or
animals when exposed to it.
• Poses a higher degree of risk than Category B
• Must be assigned either:
➢ UN2814, Infectious substances, affecting humans
✓ Humans or both humans and animals
➢ UN2900, Infectious substances, affecting animals only
✓ Only animals
• Classification is based on:
➢ Known medical history or symptoms of the source patient or
animal
➢ Professional judgment regarding the individual circumstances of
the source human or animal
➢ Infections unique to the geographic area
Note: See TABLE 3.6.D for examples of Category A Infectious Substances
INFECTIOUS SUBSTANCES
UN2814 and UN2900 Category A - general requirements
Shippers are responsible for ensuring that packages of infectious substances
are prepared in a manner that:
• Prevents risk to persons or animals during transport
• Ensures packages arrive at their destination in good condition
Packagings:
• UN performance-oriented packaging:
➢ Successfully tested to its standard
➢ Must bear UN performance markings
• Must be filled and closed to prevent loss of contents
• Primary receptacles or secondary packaging must be able to withstand
without leakage:
➢ Pressure differential ≥ 95 kPa (0.95 bar)
➢ Temperatures in the range of -40°C to 55°C
INFECTIOUS SUBSTANCES
UN2814 and UN2900 Category A - packaging
Packaging must include:
• Leak-proof primary receptacle(s)
• Leak-proof secondary packaging:
➢ Multiple fragile primary receptacles individually wrapped or
separated to prevent contact between them when packed in a single
secondary packaging
➢ Sufficient absorbent material to absorb entire liquid contents:
✓ Placed between primary receptacle(s) and secondary packaging
• Itemized list of contents placed between secondary and outer packaging
• Rigid outer packaging:
➢ Smallest external dimension not less than 100 mm
[shipper’s name
[shipper’s and address]
name and address]
[1]
[1] [1]
[1]
[consignee’s namename
[consignee’s and address]
and address]
XXXXXX
XXXXXX XXXXXXXXXX
Chemtrec:
Chemtrec:
1-800-424-9300 (USA)
1-800-424-9300 (USA)
1-703-527-3887 (International)
[Name
[Name]
[Date]
1-703-527-3887 xxxxxx
Contract Number:
[Date] (International)
[Signature]
[Signature] Contract Number: xxxxxx
INFECTIOUS SUBSTANCES
Shipper’s Declaration – Overpack
XXXXX
XXXXXXXXXX
Chemtrec:
1-800-424-9300 (USA)
[Name] 1-703-527-3887
[Date] (International)
[Signature] Contract Number: xxxxxx
INFECTIOUS SUBSTANCES
Shipper’s Declaration – Multiple Overpacks
• Each overpack entry of a consignment with multiple overpacks must include:
➢ A unique alpha-numeric identifier (any format) in association with the
words “Overpack used”
➢ Total quantity and unit of measure of dangerous goods in the overpack
• The alpha-numeric identifier and total quantity must also be marked on the
overpacks and match those on the Shipper’s Declaration
NATURE AND QUANTITY OF DANGEROUS GOODS
Dangerous Goods Identification
UN or Class or Packing
Packing Quantity and type of packing Authorization
ID No. Proper Shipping Name Div. (sub. Instr.
Group
hazard)
UN2814 Infectious
UN substance
Flammable affecting
liquid, n.o.s., 6.2 4 50
Fibreboard
Fibreboardboxes 355 620
boxesxx 60 ml
3 III
humans
1993 (EbolaXXXXXXX
virus)
(petroleum naphtha, xylene) Overpack
50 L. used
OP1 - 240 ml
XXXXXXXXXXXX
UN2900 Infectious substances, affecting 6.2 2 Fibreboard boxes x 50 g 620
animals (Rinderpest virus)
Shipper:
Consignee:
Jane Doe
123 456-7890
INFECTIOUS SUBSTANCES
UN3373 Category B –documentation
• A Shipper’s Declaration for Dangerous Goods is not required.
• When an Air Waybill is used, the “Nature and Quantity of Goods” box
must show:
➢ UN3373
➢ Biological substance, Category B
➢ Number of packages
➢ The name and telephone number of a person responsible when
not on the package
• Shipments are subject to:
➢ 9.6.1 operator incident reporting requirements
➢ 9.6.2 operator undeclared and mis-declared dangerous goods
incidents
• Each person who offers or transports a Category B biological
substance under the provisions of Packing Instruction 650 must be
instructed on the requirements of Category B
Infectious Substances
Category A Category B
Substances capable of
Specimens or cultures
causing permanent disability,
containing pathogens not
life-threatening or fatal
expected to permanently
disease in otherwise healthy
harm humans and animals
humans or animals
(1) (2) (3) (4) (5) (6) (7) (8A) (8B) (8C)
G Regulated medical waste, 6.2 UN3291 II 6.2 41, A13, 337 134 197 197
n.o.s.,
(Bio) Medical waste, n.o.s.,
Biomedical, waste, n.o.s,
Clinical waste,
unspecified, n.o.s.,
Medical waste, n.o.s.,
Column 1- “G” - Technical name(s) required in parentheses following the proper shipping name
Column 7- details for the special provisions assigned to an entry are in §172.102
Column 8A- exceptions to the standard non-bulk packaging requirements (least restrictive)
Column 8B- location of packaging requirements for non-bulk packagings
Column 8C- location of packaging requirements for bulk packagings
REGULATED WASTES
DOT - §172.102 Special provisions
Apply to all modes of transport:
41 Regulated medical waste material at the Packing Group II hazard criteria level
may be transported in Large Packagings.
337 Authorizes the use of regulated waste containers manufactured prior to
October 1, 2006 to be marked with the alternative shipping name of Regulated
medical waste, UN3291 and arrows that deviate as prescribed in §172.312(a)(2) in
that they may be black or white
Apply to air transport only:
A13 Bulk packagings are not authorized for transportation by aircraft.
REGULATED WASTES
IATA – List of Dangerous Goods
Cargo Aircraft
Passenger and Cargo Aircraft
Only
Class Ltd Qty
or Max
Div. EQ Net S.P.
UN/ Proper Shipping (Sub. Hazard P See Pkg Qty/Pk Pkg Max Net Pkg Max Net See ERG
ID No Name/Description Risk) Label G 2.6 Inst g Inst Qty/Pkg Inst Qty/Pkg 4.4 Code
A B C D E F G H I J K L M N
3291 Biomedical waste, 6.2 Infectious E0 Forbidden 621 no limit 621 no limit A117 11L
n.o.s. substance
3291 Clinical waste, 6.2 Infectious E0 Forbidden 621 no limit 621 no limit A117 11L
unspecified, n.o.s. substance
3291 Medical waste, n.o.s. 6.2 Infectious E0 Forbidden 621 no limit 621 no limit A117 11L
substance
3549 Medical waste, 6.2 Forbidden Forbidden Forbidden A2 11L
Category A, affecting A218
animals only solid
3549 Medical waste, 6.2 Forbidden Forbidden Forbidden A2 11L
Category A, affecting A218
humans solid
3291 Regulated medical 6.2 Infectious E0 Forbidden 621 no limit 621 no limit A117 11L
waste, n.o.s. substance
REGULATED WASTES
IATA – 4.4 Special provisions
A2 This article or substance may be transported on cargo aircraft, only with
prior approval of and written conditions established by the appropriate
authority of the State of origin and the State of the operator.
• Prior approval of and written conditions established by States of
transit, overflight and destination must be obtained when required
• In each case, a copy of the document(s) of approval, showing the
quantity limitations and packaging requirements, must accompany the
consignment
A117 Wastes containing Category A infectious substances must be assigned
to UN2814 or UN2900, and wastes containing infectious substances
Category B or that have a low probability of containing infectious substances
assigned to UN3291
A218 This entry (UN3549) must only be used for solid medical waste of
Category A transported for disposal
REGULATED WASTES
What is regulated medical, clinical or biomedical waste?
UN3291 regulated medical, clinical or (bio)medical waste means a waste or
reusable material derived from the medical treatment of a human, an animal or
from biomedical research.
• May not contain Category A infectious substance
• May contain Category B infectious substance
• Medical or clinical waste reasonably believed to have a low probability
of containing an infectious substance
➢ Hypodermic needles or other sharps contaminated with a
pathogen
➢ 6.1 Toxins from a plant, animal, or bacterial source
➢ Used health care products- medical, diagnostic or research
devices, equipment or personal care products contaminated with
potentially infectious body fluids or materials
➢ Patient specimens not permitted unless non-regulated biological
product
REGULATED WASTES
Class 6, Division 6.2 – Regulated Wastes
Medical or clinical wastes are wastes derived from the veterinary treatment of
animals, the medical treatment of humans or from bio-research.
• Must be classified in Division 6.2 and assigned to the appropriate UN
number:
➢ UN3291 – Category B waste and waste that does not contain or
has low probability of containing infectious substance
✓ Biomedical waste, n.o.s.
✓ Clinical waste, unspecified, n.o.s.
✓ Medical waste, n.o.s.
✓ Regulated medical waste, n.o.s.
➢ UN3549 (IATA only) – Solid medical waste containing Category A
infectious substance transported for disposal
✓ Medical waste, Category A, affecting animals; or
✓ Medical waste, Category A, affecting human.
✓ Approvals and documentation requiried
REGULATED WASTES
§173.134(c) - Exceptions for regulated medical waste
Two 49 CFR exceptions from UN specification packaging when the waste
is not a hazardous substance, a hazardous waste or a marine pollutant.
1. When transported by a private or contract carrier:
• Package may display a “BIOHAZARD” marking (OSHA 29 CFR
1910.1030) or an “INFECTIOUS SUBSTANCE” label (49 CFR)
• Rigid non-bulk packaging - designed, constructed, maintained,
filled, contents limited, closed and secured according to 49 CFR
§173.24 and §173.24(a) and OSHA 29 CFR 1910.1030:
➢ May not include an infectious substance waste concentrated
stock culture
➢ Sharps containers must be securely closed to prevent leaks
or punctures
UN3291 UN3291
Clinical waste, Clinical waste,
unspecified n.o.s. unspecified n.o.s.
(forensic) (forensic)
Shipper Shipper
or or
Consignee: Consignee:
REGULATED WASTES
Exceptions for regulated medical waste (cont.)
2. When transported by private or contract carrier in a vehicle used
exclusively to transport regulated medical waste:
• Rigid non-bulk packaging - designed, constructed, maintained,
filled, contents limited, closed and secured according to 49 CFR
§§173.24 and 173.24(a) and OSHA 29 CFR 1910.1030
• Waste may include:
➢ Waste stock or culture of a Category B infectious substance
➢ Animal and Plant Health Inspection Service regulated wastes
➢ Waste pharmaceutical materials
➢ Laboratory and recyclable wastes
➢ Infectious substances treated to eliminate or neutralize
pathogens
➢ Forensic materials being transported for final destruction
➢ Rejected or recalled health care products
REGULATED WASTES
Exceptions for regulated medical waste (cont.)
➢ Documents for destruction according to Health Insurance
Portability and Accountability Act (HIPAA)1996 requirements
➢ Medical or clinical equipment and laboratory products properly
packaged and secured against exposure or contamination
➢ Sharp containers securely closed to prevent leaks or punctures:
✓ Maximum capacity - 18 gallons
✓ Registered under the Medical Device Regulations of FDA
✓ ASTM Standard F2132-01 puncture resistant plastic
✓ Securely fitted and held in upright position in wheeled racks:
• Must contain full rows of sharps containers secured in
place by a moveable bar
• Securely held in place on the motor vehicle by straps or
UN3291 Clinical waste, load bars
unspecified, n.o.s.
(recyclable)
• Rack’s shelf may not exceed recommended capacity
Shipper
or
Consignee:
REGULATED WASTES
UN3291 Regulated waste label & Biohazard labels
REGULATED WASTES
DOT & IATA - Fully regulated waste packaging
Consignments must be packed so that they arrive at their destination in good
condition and present no hazard to persons or animals during transport.
• A UN specification packaging shown in the table is required:
➢ Packing Group II performance standard (X or Y)
➢ Packaging certified for solids is permitted for liquids when:
✓ Capable of retaining liquids; and
✓ Packed with sufficient absorbent material to absorb all liquid
➢ Packagings containing sharp objects must be:
✓ Resistant to puncture; and
✓ Retain liquids under the performance test conditions
OUTER PACKAGINGS
Steel Aluminum Plywood Fibre Plastic Other Wood Reconstituted Fibreboard
metal Wood
Drums 1A2 1B2 1D 1G 1H2 1N2
Jerricans 3A2 3B2 3H2
Boxes 4A 4B 4D 4G 4H1, 4H2 4N 4C1, 4C2 4F 4G
REGULATED WASTES
DOT & IATA - Fully regulated waste marks and label
Outer packagings must display:
• UN Specification packaging mark
• UN number
• Proper shipping name
➢ DOT requires technical name(s)
• Names and addresses of shipper and consignee
➢ Shipper or consignee (DOT)
• Package orientation label on two opposite vertical sides (for liquids)
• Division 6.2 infectious substance label
Name or signature
REGULATED WASTES
IATA – Shipper’s Declaration for Dangerous Goods
[shipper’s name
[shipper’s and address]
name and address]
[1]
[1] [1]
[1]
[consignee’s namename
[consignee’s and address]
and address]
XXXXXX
XXXXXX XXXXXXXXXXXX
UN3291 Clinical waste, unspecified, n.o.s. 6.2 1 Fibreboard box x 12.4 kg 621
Chemtrec:
Chemtrec:
1-800-424-9300 (USA)
1-800-424-9300(International)
1-703-527-3887 (USA)
[Name
[Name]
[Date]
1-703-527-3887 xxxxxx
Contract Number:
[Date] (International)
[Signature]
[Signature] Contract Number: xxxxxx
DOT & IATA - DIVISION 6.2 & DRY ICE
Identification
Label Code
Hazardous Materials
Number
Description and Hazard Special Ex-
Symbol
FROZEN FISH
DRY ICE - 4 lbs.
DRY ICE
IATA – 4.2 List of Dangerous Goods
Cargo Aircraft
Passenger and Cargo Aircraft
Only
Ltd Qty
Class Max
or Div. EQ Net S.P.
UN/ ID Proper Shipping (Sub. Hazard P see Pkg Qty/Pk Pkg Max Net Pkg Max Net see ERG
No Name/Description Risk) Label G 2.6 Inst g Inst Qty/Pkg Inst Qty/Pkg 4.4 Code
A B C D E F G H I J K L M N
1845 Carbon dioxide, solid † 9 Misc. E0 Forbidden 954 200 kg 954 200 kg A48 9L
A151
A805
1845 Dry ice † 9 Misc. E0 Forbidden 954 200 kg 954 200 kg A48 9L
A151
A805
XXXXXX
XXXXXXXXXXXX