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CATHERINE LaROCHE, M.D. NANCY FULLER, M.S.W.

MARTINE LALINEC-MICHAUD, M.D. MARIAN COPP, B.N.


FRANK ENGELSMANN, Ph.D. KAREN VASILEVSKY, P.S.W.

Grief reactions to perinatal


death: An exploratory study
ABSTRACT: Mothers who lose a baby may show inappropriate be pregnant, (2) they had previ-
grief reaction (lG R) at varying times following the event. The ously lost a baby, and (3) there was
authors describe an interdisciplinary crisis-intervention team a failure of communication be-
aimed at assessing and reducing pathologic grief in such mothers, tween the woman and her husband.
and report their preliminary findings. Among the factors found They found that the type of
associated with increased risk of IG R are the mother's desire for mourning reaction did not differ
with the length of time the baby
a baby, history of previous psychiatric problems, premature
had lived.
birth, failure to see the baby, and poor communication between In 1972, Cullberg1 reported that
the parents. 19 of 56 women who had lost babies
suffered pathologic grief and a va-
For some time now, the staffs of help prevent pathologic grief reac- riety of psychiatric problems one to
medical and surgical services have tions. Based on our experience with two years after the perinatal loss.
been sensitized to the pathologic a multidisciplinary research and Those women who had initially
consequences of poorly resolved treatment team, we drew up a pro- suppressed their feelings were par-
grief reactions associated with tocol for management of grief reac- ticularly prone to prolonged mental
chronic illness and death in the tions to perinatal death and under- symptoms.
family. This increased awareness- took an exploratory study, which Wolff and associates3.4 followed
and the therapeutic interventions we report below. up 40 women one to three years
that have developed from it-have after perinatal loss. They found
been slower to reach obstetric and Previous studies that all the mothers experienced an
neonatal units. Published reports In 1970, Kennel and associates,' as initial grief reaction but that signif-
suggest that improved communica- part of a larger study on maternal- icant psychiatric difficulties oc-
tion between the medical staff and infant separation, found that there curred in only two women, both of
mothers who have suffered peri- was more intense mourning among whom had been treated for pre-
natal loss, as well as between these mothers who had lost their babies vious mental or emotional distur-
mothers and their husbands, may when (I) they had been pleased to bances. The authors noted, how-
ever, that the small incidence of
From the Child and Adolescent Service and the Women's Pavilion, Allan Memorial pathologic findings in their sample
Institute and Royal Victoria Hospital, Montreal. Reprint requests to Dr. LaRoche, may have been related to the inad-
Royal Victoria Ho.~pital, 687 Pine Ave W, Montreal, Quebec. H3A JA J, Canada. vertent therapeutic effect of peri-

510 PSYCHOSOMATICS
odic comprehensive interviews, the comparison with other models de- Sample and procedure
main goal ofwhich was to gain and scribed in the literature l revealed Our sample consisted of 31 mothers
collect research data. that perinatal deaths were being from the obstetric department of
A surprising finding was the dealt with in individualistic ways, the Women's Pavilion at Royal
number of mothers (eight) who largely dependent on the intuition Victoria Hospital who had lost
were adamant about not having of the physician and other profes- babies before birth or during the
another baby. Four of these eight sional staff who were involved. first month oflife in 1979. Maternal
resorted to sterilization. Twenty Following several interdisciplin- age ranged from 18 to 34 years,
women who did have subsequent ary conferences, aimed at raising with an average of 26 years.
pregnancies sought other obstetri- the level of staff awareness and All of the women but two were
cians. promoting staff support systems, a married; one was single and the
In the 1978 study of Rowe and' protocol for management of peri- other had separated from her hus-
associates,S six of 26 mothers expe- band. More than half (16) of the
rienced grief reactions that lasted sample were of North American
12 to 20 months. The most vulnera- The investigators found a origin. Six were born in the Carib-
ble women were those who had a correlation between the bean region, one was born in Asia,
surviving twin or who became degree ofdissatisfaction with and eight in Europe. Fifteen
pregnant again less than five mothers indicated that they spoke
months after the perinatal death.
the medical care received English at home; II were French-
The investigators also found a cor- and the mother's extreme speaking. The majority of mothers
relation between the degree of dis- griefreaction. (65%) were Catholic; 26% were
satisfaction with the medical care Protestant.
received and the mother's extreme The mothers were interviewed
grief reaction. natal death was drawn up and im- for approximately one hour. one to
plemented by the obstetrics and two days after the loss of their child.
Interdisciplinary approach neonatology departments. An im- Whenever possible, fathers were
Effective liaison between psychia- portant component of the new pro- also included in the interview. The
try and other medical services often tocol is the crisis intervention that is plirpose was to assess and facilitate
develops most naturally through offered to parents in an attempt to the grief process, to clarify misun-
interdisciplinary teams that form in facilitate their grief process. Video- derstandings and confusion, and to
response to crises. Our treatment tapes of several crisis-intervention encourage communication be-
and research team, which consists interviews have been used effec- tween husband and wife and be-
of representatives from the depart- tively for in-service training. In ad- tween parents and mc:dical staff.
ments of social service, nursing, dition, a booklet for parents that On the basis of the interview, a
psychiatry, psychology, obstetrics, describes available services is being structured form was completed that
and neonatology, grew out of a prepared, and efforts are under way included clinical and sociodemo-
number of shared experiences. to organize in the community a graphic variables such as educa-
For more than a year, a group of self-help group for parents tion, social class, occupation, living
nurses, a social worker, and a psy- bereaved of a newborn. space, and support system. Tele-
chiatrist had met regularly to try to We also undertook an explor- phone and direct contact were
deal with perinatal death in terms atory study with two aims: (I) to made by the same interviewer two
of its painful impact on both fami- examine the relationships between to three weeks later and again after
lies and staff. At the same time, the appropriate and inappropriate approximately three months.
nursing department had become grief reactions and a number of Assessments of grief reaction
aware, from responses to question- sociodemographic and clinical were based on these interviews,
naires, of considerable dissatisfac- variables, and (2) to evaluate the using the criteria of Parkesb and
tion that some parents felt with effects of crisis intervention on Lindemann.' These criteria include
hospital procedures related to a mothers at the time of the immedi- somatic distress, intense subjective
stillbirth or loss of a newborn. Re- ate loss of their baby and at follow- distress, preoccupation with an
view of our hospital practices and up contacts. image of the deceased. feelings of
(continued)

MAY 1982· VOL 23 • NO 5 511


Brief Summary of Prescribing Information
Adaplne
(dOxepin HCI) Capsules
Perinatal death
Indication. Relief of symptoms of anxiety
and depression.
Contraindication. Glaucoma. tendency
toward urinary retentiOn or hypersenSitivity to
doxepin. guilt due to negligence, feelings of Inappropriate grief reaction. At
WIlrnlng. Adapin has not been evaluated for hostility toward others, and a the three-month follow-up, one
safety in pregnancy. No evidence of harm to
the animal fetus has been shown in reproduc- breakdown of normal patterns of mother was still crying daily, had
tive studies. There are no data concerning conduct. frequent nightmares about her
secretiOn in human milk. nor on efleet in nurs-
ing infants. Clinical observation and evalua- baby, experienced somatic com-
Usage in children under 12 years of age is tion of these items were the basis plaints, and could not concentrate.
not recommended. MAO inhibitors should be for a clinical impression of the Another mother, who initially and
discontinued at least two weeks prior to the
cautious initiation of therapy with this drug. as mother's grieving behavior, which at the first follow-up exhibited little
serious Side-efleets and death have been re- we classified as either "appropriate sadness or preoccupation with the
ported with the concomitant use of certain
drugs and MAO inhibitors. grief reaction" (AOR) or "inappro- loss of the baby, at three months
In patients who may use alcohol exces- priate grief reaction" (lOR). An complained of nervousness to the
Sively. potentiation may increase the danger lOR was overly intense or shallow point of having difficulty leaving
inherent in any suicide attempt or overdosage.
Precaution. Drowsiness may occur and compared to an AO R, or was ab- her home. She claimed she had not
patients should be cautioned against driving sent. The following examples illus- had this problem before the still-
a motor vehicle or operating hazardous ma- trate the two categories. birth.
chinery. Since suicide is an inherent risk in
depressed patients. they should be closely Appropriate grief reaction. The
supervised while receiving treatment. Al- mother cried several times a day for Data analysis
though Adapin has shown efleetive tranquiliZ-
ing activity. the posSibility of activating or a few weeks. She had trouble sleep- Data were analyzed by means of
unmasking latent psychotic symptoms should ing and sometimes dreamed of the computers applying the Statistical
be kept in mind.
This product contains FD&C Yellow NO.5 baby. She questioned whether the Package for Social Sciences (Nie
(tartrazine) which may cause allergic-type re- premature labor was her fault and and associates8). The significance of
actions (including bronchial asthma) in certain expressed some anger at the physi- differences was determined by chi-
susceptible individuals. Although the overall
incidence of FD&C Yellow NO.5 (tartrazine) cian, who she felt had avoided her square techniques applied to the
senSitivity in the general populatiOn is low. it is after the stillbirth. Three months contingency tables using Yates's
frequently seen in patients who also have
aspirin hypersensitivity. later, the mother still felt sad and correction for small frequencies.
Adv. . . RNCtiona Dry mouth. blurred cried occasionally, but she had
viSion and constipatiOn have been reported. started to resume her normal pat- Findings
Drowsiness has also been observed. Eleven of the 31 mothers displayed
Adverse efleets occurring infrequently tern of living and planned to return
include extrapyramidal symptoms. gastro- to work soon. an inappropriate grief reaction
intestinal reactiOns. secretory efleets such as (continued)
sweating. tachycardia and hypotenSion.
Weakness. dizziness. fatigue. weight gain.
edema. parestheSias. flushing. chills. tinnitus.
photophobia. decreased libido. rash and pruri- of ... M_ma' Grief
tus may also occur.
DoMge and Admlnl.tnltlon In mild to
or Perlnata' De"'"
moderate anxiety andlor depression: 25 mg
t.i.d. Increase or decrease the dosage accord-
ing to individual response. Daily dosage. up to Flnt Second
150 mg may be taken at bedtime without loss follow-up Iollow-up
of eflectiveness. Usual optimum daily dos- (2-3_) (3mo)
age is 75 mg to 1SO mg per day not to exceed
300 mg per day. 1 X X
Antianxiety efleet usually precedes the
antidepressant efleet by two or three weeks. 2 X X
How Supplied Each capsule contains doxe- 3 X
pin as the hydrochloride. 10. 25. SO. 75 and 4 X
100 mg capsules in bottles of 100 and 1000. 5 X
For complete prescribing information.
please see package insert or PDA. 8 X
R~
7 X
1. Data on file. Medical Department. X X X
Pennwalt Pharmaceutical DiviSion. X
2. Barranco SF. Thrash ML. Hackett E. X X
et a1: Early onset of response to doxepin treat-
mentJ Clin Psychiatry 40:265·269.1979.- X X
·Sinequane brand of doxepin HCI was the
drug used in this study.

SI4 PSYCHOSOMATICS
..... ~otPre....... In..........
................ UuIr. Management of anxlety disorders Ot short-term rellel of symptoms of
anxiety or anxiety associaled with depreaive symPletnS. Anxiety Ot tension assoclaled with
stress 01 everyday me usually does not require trealment with an anxiolyliC.
Effectiveness in long-term use. i.e.. more than 4 months. has not been assessed by system- Perinatal death
atic clinical studies. Reassess periodically usefulness of the drug lOt the Individual patient.
COO........-........: Known sensrtMly 10 benzodiazep;nes Ot acute narrow-angle glaucoma.
WerIIInlIa: Not recommended in primaty depressive disOtders Ot psychoses. 1.$ with all CNS-
acting drugs. warn palienlS not to operate machinety Ot motor llehicles. and of dimini8hed Iol-
erance for alcohol and other CNS depressants.
Physical and Psychological Dependence: Wrthdrawal symptoms like lhose noled with barbi- (IGR) at the initial evaluation or
Iurales and alcohol have occurred tollowing abrupt diaCOnIinuance of benzo<liazepines
(including convulsions. Iremor. abdominal and muscle cramps. vomiting and -'ing). Addic- follow-up assessments. There was
tion-prone individuals. e.g. drug addicts and alcoholics. ahould be under careful surveillance
when on benzo<liazep;nes because of their prediaposilion to habilualion and dependence. considerable variation in the IGR
Withdrawal symptoms have also been reported following abrupt disconlinuance ot benzo<li-
azep;nes taken continuously atlherapeutic levels for several morrlha.
occurrence over the period of ob-
PNoautIona: In depression accompanying anxiety. consider possibility fOt suicide. servation. Table I indicates that
For ekIerty or debilrtaled patients. initial daily dosage ahould nol exceed 2mg 10 avoid over·
sedation. Terminale dosage gradually since abrupt withdrawal of eny antianxiety egent may
there was a core group of mothers
resun in symplOms like Ihose being Ireated: anxiety. agrtation. irritability. tension. inSOmnia and with IGR; five of those showing
occasional convulsions. Observe usual precautions with impaired renal Ot hepatic function.
Where gastrOinlestinal or cardiovascular disorders coexist with anxiety. note that Iorazepam this reaction at the first follow-up
has not been shown of significant benelil in treating gastroinlestinal or cardiovasculer com!»'
nant. Esophageal dilatiOn occurred in rats treated Wrth Iorazepam for more than 1 year at
were still showing it at the second
6mg/kg/day. No elI8CI dosa was 1.25mg/kg/day (about 6 times maximum human therapeutic assessment. The one mother with
dose of1Omg/day). Effect was reve<sible only when treatment was withdrawn wrthin 2 months
01 first observatiOn. Clinical significance is unknown; but use 01 Ionazepam tor prolonged IGR at the initial assessment and
periods and in gerialrics requires caution and frequent monrtoring for symptoms of upper G.!.
disease. Safety and elIecliveness in children under 12 years have not been establi8hed. both follow-up contacts suffered a
ESSENTIAL LABORATORY TESTS: Some patients have developed leukoPenia: some have had
elevations 01 LDH. 1.$ with _ benZo<liazep;nes. periodic bIoocl counts and liver function tests
are recommended during long-term therapy.
CLINICALLY SIGNIFICANT DRUG INTERACTIONS: Benzo<liazepines pro<luce CNS depressant Eleven ofthe 31 mothers
eIlects when administered Wrth such medicatiOns as barbiturates Ot alcohol.
CARCINOGENESIS AND MUTAGENESIS: No evidence 01 carcinogenic potential emerged in
displayed an inappropriate
rats during an 18-month study. No studies regarding mutagenesis have been performed.
PREGNANCY: Repro<Iuclive studies were performed in mice. rats. and 2 strains of rabbits.
griefreaction (lGR) at the
Occasional anomalies (reductiOn 01 tarsals. tibia. metatarsals. malrotated limbs. gastroschisis.
manormed skull and microphthalmia) were seen in drug-treated rabbits wrthoul relationship to
initial evaluation or
dosage. Although all these anomalies were not present in the concurrent control group. they
have been reported 10 occur randomly in hiSforicat controls. AI40mg/kg and higher. there was
foHow-up assessments.
evidence 01 telal resorption and increased fetal loss in rabbits which was not seen at lower
doses. Clinical significance 01 these findings is not known. ..-sr. increased riSk of congeni-
lal manOtmations asociated with use Of minOt tranquilizers (chlordiazepoxide. diazepam and
meprobamate) during first trimester 01 pregnancy has been suggested in _ a l studies.
clear manic-depressive illness after
Because use 01 these drugs is rarely a maner 01 urgency. use of Iorazepam during thiS period the stillbirth.
ahould almost always be avoided. Possibility that a woman of child-be8rlng potential may be
pregnant at instrtution 01 therapy ahould be considered. AdvIse palienlS Wthey become preg- The commonest causes of still-
nant to communicate with their physician abOUI desirability 01 discontinul"9 the drug. In
humans. bloo<lleve/S from umbilical cord bIoo<I indicate placental transfer oflorazepam end rtI
birth among women demonstrating
glucuronide. IGR were prematurity, eclampsia,
NURSING MOTHERS: n is not known II oral Iorazepam is excreted in human milk like other
benzodiazepinee. As a general rule. nursing ahould not be undertaken while on a drug since and placental problems. Among
many drugs are excreted in mHk. women with AG R, malformation
~ ........... Wthay occur. ere usually observed at beginning 01 therapy and generally
disappear on continued medicatiOn or on decreasing dose. In a sample of abOUI3.500 anxious was the commonest cause; no mal-
palienlS. most frequent actvwse reection is sedation (15.~). followed by dizziness (6.~).
weak_ (4.2'llo) and unateadiness (3.4%). Less frequent are diSorientation. depression. nau-
formation was reported among
sea. change in appetite. headache. sleep disturbance. agrtatiOn. dermatological sympletnS. eye babies of mothers showing IG R.
function disturbance. variOUS gastrointestinal symptetn5 and autonomic manileslations. Inci-
dence of sedatiOn and unsteadiness incnsesed with age. Small decr_ in bIoocl pressure IGR was not related to age nor in
have been noted bul are not clinically significanl. probably being related to relief of anxiety.
0-.1.", In manegemenl of overdosage with any drug. bear in mind mulliple agents may
any conclusive way to gravidity,
have been taken. ManifestatiOns 01 overdosage include somnolence. confusion and coma. parity, or previous abortions. More
Induce vomrting and/or undertake gastric lavage lollowed by general supportive care. monrtOt-
ing vrtal Signs and cJo8e obIetvatiOn. Hypotension. though unlikely. usually may be controlled than half of the women with IG R
wrth Levarterenol Bitartrate InjectiOn U.S.P. Useful_ of dialysis has not been determined.
(six of I I) reported no previous
obstetric or gynecologic problems;
five reported such problems as in-
fertility, difficult pregnancy, and
premature birth. There were no
significant relationships between
IGR and labor complications or
DoNge: Individualize for maximum beneftclal effeds. Increase dolIe hospitalization during the preg-
gradually when needed, giving higher evening dolIe before increasing
d8yIime dolIes. AnxIety, uala11y 2-3mg/day given b.l.d. or Ll.d.; douge nancy. Nor did the sex of the baby
m., VIIIJ from 1 to 1lJmg/day In divided doNs. For elderly or debilI- seem related to the type of grief
tated, Inlllally 1·2mg/day; insomnia due to anxiety or ....lIIenI 1Itu. reaction.
tlonal ........ 2.-mg h.••
There was no association be-
How ...".,,: 0.5, 1.0 and 2.lJmg tabIeIs. tween IG R and touching or not
touching the baby, and there
seemed to be none between the

516 PSYCHOSOMATICS
Wyeth LabOIatories ~~
I~
Philadelphia. PA 19101
type of grief reaction and whether c1udes from his clinical studies that
the hospital or family disposed of There were no significant the mourning process of women
the dead baby. There appeared to relationships between IGR losing a desired baby may take
be no association between 10 Rand and labor complications or from 18 to 24 months to resolve.
preceding crises or recent death in hospitalization during the Lewisii further notes that the
the family. pathologic effects of unresolved
pregnancy.
Table 2 shows the positive rela- grief reactions may only manifest
tions we found: between lOR and themselves in bonding problems
unexpected stillbirth, gestation with a subsequent child.
length, and failure to see the baby. ings from most studies is the small Taking into account these time-
Those women who had not ex- sample size, due to the improved related methodologic problems, we
pected a stillbirth, those who had neonatal care that is increasing can identify a number of specific
had premature deliveries, and chances of infant survival. Another factors associated with the in-
those who did not have the oppor- difficulty in comparing studies creased risk of unusual grief reac-
tunity to see their babies experi- arises from the variations in time tions: a mother's desire for a baby,
enced more lOR (these were all between perinatal death and fol- previous psychiatric problems, fail-
trends not reaching statistical sig- low-up assessments.I.IO ure to see the infant, and commu-
nificance). Additionally, there was In spite of the limited sample nication problems between the
a trend between planned preg- size, our study demonstrates that parents. The study by Rowe and
nancy and lOR; those mothers who the mourning process is a dynamic associates 5 showed an association
had planned their pregnancies had one, with individual differences in between prolonged maternal griev-
more lOR (eight of 21, or 38%) reaction over time. To gain a ing and a surviving twin or sub-
compared with those who did not clearer understanding of the evolu- sequent pregnancy within five
(two of eight, or 25%). tion of the mourning process, ex- months of the death. Our own
tended follow-up assessments will study has shown a higher incidence
Discussion be needed. At this point we cannot of lOR among mothers who gave
Some investigators9 claim it is im- predict which unexpected grief re- birth prematurely and unexpec-
possible to predict which mothers actions may resolve normally and tedly.
who lose a baby are at highest risk which may become more severe or
for pathologic grief reactions. The last beyond (jur three-month eval- Future directions
main difficulty in evaluating find- uation. Indeed, Davidson 9 con- Evaluating the relationship be-
tween crisis-intervention and
pathologic grief is a complex task.
Isolating the specific impact of
Tllble 2-Varlable Affecting Inappropriate crisis intervention from the overall
Maternal Grief Reactions input of the multidisciplinary team
approach that influences the atti-
N lOR tude and behavior of all staff
toward patients is difficult but nec-
StIllbirth essary. The active and useful ele-
Expected 9 2(22%)
Unexpected 22 9(41%)
ments within the crisis intervention
model must be elucidated. Facilita-
BIrth ..... tion of grief by focusing on feelings
Premature 19 8(42%)
of distress about the loss. outlining
Normal 11 3(27%)
possible future manifestations of
Postmature 1 o grief, and promoting greater com-
SeeIng b8bJ munication and support between
No 7 4(57%)
family members may need to be
Ves 24 7(29%)
supplemented by recognition of in-
dividual differences in coping, both

MAY t982, VOL 23· NO 5 SI7


Perinatal death

in the individual's style and time. ing control groups-interventions disciplinary team approach could
Control and comparison groups that have been shown to have posi- be tested by carefully thought-out
are needed. but from an ethical tive therapeutic effects. Perhaps the and conducted comparison with
viewpoint it seems untenable to usefulness ofspecific strategies such studies involving other approaches
withhold-for the sake of establish- as crisis intervention and the inter- to perinatal death. 0

REFERENCES
1 Kennel JH. Slyter H. Klaus M: The mourning In Morris N (ed): Psychosomatic Medicine In 8. Nie H, Hull CH, Jenkins JG, et al: Sta/ls/lcal
response of parents to the death of a new- Obstetrics and Gynecology, 3rd Int Con- Package for the Social SCiences. New York,
born Infant NEngIJMed283344-349. 1970 gress. London, Karger, 1972. pp 330-332. McGraw Hill, 1975.
2 Cullberg J Mental reactions of women to 5 Rowe J, Clyman R, Green C, et al Follow-up 9. Davidson GW: Underslanding Death of the
perinatal deafh. in Morns N (ed) Psychoso· of families who experience a perinatal death. Wished· for Child. Springfield, III. OGR Ser-
matlc Medicine In Obstetncs and Gynecol- Pediatrics 62: 166-170. 1978. vice Corp, 1979.
ogy. 3rd Int Congress. London. Karger. 1972, 6. Parkes CM: Bereavement and mental illness, 10 Peppers LG, Knapp R: Maternal reactions to
pp 326-329 pt 1: A clinocal study of the gnet of bereaved Involuntary tetal/lnfant death. Psychiatry
3 Wolft JR. Nielson PE, Schiller P The emo- psychiatric patients. Br J Med PsychoI38:1- 43155-159,1980
tional reactIon 10 a stillbirth. Am J Obslet 12,1965 11 Lewis E, Page A Failure to mourn a stillbirth:
Gyneco/l0873-77. 1970 7. Lindemann E: Symptomatology and manage- An overlooked catastrophe. Br J Med Psychol
4 Wolft JR: The emotoonal reaction to stillbirth. ment of acute grief. Am J Psychiatry 51 :237-241. 1978
101.141-148.1944

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518 PSYCHOSOMATICS

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