Abstracts e31

ORAL SESSION
ISH AUSTIN DOYLE AWARD SESSION
STUDY ON REDUCTION OF MICROALBUMINURIA AMONGST
HYPERTENSIVE PATIENTS WITH USE OF TRIPLE COMBINATION
THERAPY (TRIPLIXAM)
Abhishek Arun. MV Hospital and Research Centre, Lucknow, INDIA
Objective: Persistent microalbuminuria is earliest indicator of Chronic Kidney
Disease amongst hypertensive patients and is also associated with target organ
damage resulting in stroke, retinopathy and adverse cardiovascular outcomes.
The present study was aimed to evaluate the reduction in microalbuminuria amongst
uncontrolled essential hypertensive patients with use of triple combination therapy.
Design and method: It was a hospital based cross sectional prospective study
done on 50 essential hypertension patients having uncontrolled blood pressure and
presence of microalbuminuria in urine. Total duration of therapy was 3 months and
triple combination therapy used in study as antihypertensive was Triplixam (Perin-
dopril 4 mg, Amlodipine 5 mg and Indapamide 1.25 mg). Patients having Diabetes
and other co morbidities were excluded from the study. Patients were evaluated at
baseline and end of study visit for SBP,DBP, Urine for albumin excretion. Ethical
clearance was taken prior to inclusion of patients.
Results: There was significant reduction in both SBP (18 mm Hg) and DBP (10
mm Hg) with use of triple combination therapy (Triplixam). Microalbuminuria
turned to normal albumin excretion in urine that was statistically significant
(p<0.01) was most significant and convincing finding.
Conclusions: Triplixam is an excellent triple agent that can reduce blood pressure
promptly and bring about reduction in urine albumin excretion thereby decreasing risk
of end target organ damage. Early detection of renal dysfunction through microalbu-
minuria and prompt treatment can confer future protection from end stage renal disease.
M
3Institute O
West University, Potchefstroom, SOUTH AFRICA, of Toxicology, Core
Unit Proteomics, Hannover Medical School, Hannover, GERMANY, 4Institute of N
Clinical Pharmacology and Toxicology, University Medical Centre Hamburg-Ep- D
pendorf, Hamburg, GERMANY, 5Deutsches Zentrum fuer Herz-Kreislauf-Forsc- A
hung E.V. (DZHK), Partner Site Hamburg/Kiel/Luebeck, Hamburg, GERMANY Y
Objective: Lower nitric oxide bioavailabilty associates with hypertension in
O
diseased and elderly populations. With hypertension known to develop earlier
R
in black populations, we compared both plasma and urinary nitric oxide-related
markers and their associations with central systolic blood pressure and arterial A
stiffness in healthy young black and white adults. L
Design and method: We included healthy black and white men and women S
(n=1110; 20-30 years) and measured central systolic blood pressure and pulse wave
velocity, along with both plasma and urinary arginine, homoarginine, asymmetric
dimethylarginine, symmetric dimethylarginine, as well as urinary ornithine/citrul-
line, nitrite and nitrate. Additionally, the urinary nitrate-to-nitrite ratio was calculated.
Results: The black men and women had higher central systolic blood pressure and
higher plasma arginine and asymmetric dimethylarginine, but lower urinary nitrate
and urinary nitrate-to-nitrite ratio (all p<=0.003) than their white counterparts. In
single and forward stepwise multiple regression analyses, we found an inverse asso-
ciation of central systolic blood pressure (adj. R²= 0.124; b= –0.134; p= 0.006) and
plasma homoarginine in black men. Central systolic blood pressure associated in-
versely with urinary nitrate-to-nitrite ratio in black women only (adj. R²= 0.171; b=
–0.130; p= 0.029). In the white women, central systolic blood pressure associated
positively with urinary asymmetric dimethylarginine (adj. R²= 0.372; b= 0.162; p=
0.015). Pulse wave velocity associated inversely with plasma asymmetric dimethyl-
arginine (adj. R²= 0.253; b= –0.163; p= 0.024) in the white women only.
Conclusions: The lower nitric oxide synthesis and the higher central systolic
blood pressure in our black cohort support the notion of a potential increased risk
for future large artery stiffness and hypertension development in later life.

CHARACTERIZATION OF GLUCOSE UPTAKE METABOLISM IN

VISCERAL FAT BY 18F-FDG PET/CT REFLECTS INFLAMMATORY
STATUS IN METABOLIC SYNDROME

Kisoo Pahk1, Eung Ju Kim2, Yong -Jik Lee2, Sungeun Kim1, Hong Seog Seo2. 1Korea
University Anam Hospital, Department of Nuclear Medicine, Seoul, SOUTH KOREA,
2Korea University Guro Hospital, Cardiovascular Center, Seoul, SOUTH KOREA

Objective: The inflammatory activity of visceral adipose tissue (VAT) is elevated

in metabolic syndrome (MS), and associated with vulnerability to atherosclerosis.
Inflammation can be assessed by glucose uptake in atherosclerotic plaques.
Design and method: We investigated glucose uptake of VAT using 18F-fluo-
rodeoxyglucose positron emission tomography/computed tomography (18F-FDG
PET/CT) in 203 participants: 59 without MS component; M(0), 92 with one or
two MS components; M(1-2), and 52 with MS. Glucose uptake in VAT was evalu-
ated using the mean standardized uptake value (SUVmean) and the maximum
SUV (SUVmax). Glucose uptakes of immune-related organs such as the spleen
and bone marrow (BM) were evaluated using the SUVmax.
Results: VAT SUVmax correlated with high-sensitivity C-reactive protein
(hsCRP) and the SUVmax of spleen and BM, which reflect the status of systemic
inflammation. Both hsCRP and the SUVmax of the spleen and BM were higher in
the MS group than in the M(1-2) or M(0) groups. In VAT, SUVmax increased with
increasing number of MS components, while SUVmean decreased.
Conclusions: The SUVmax and SUVmean of VAT assessed by 18F-FDG PET/
CT reflected inflammation-driven unique glucose metabolism in the VAT of MS
patients, distinct from that of atherosclerotic plaques.

CENTRAL SYSTOLIC BLOOD PRESSURE RELATES INVERSELY

TO NITRIC OXIDE SYNTHESIS IN YOUNG BLACK ADULTS: THE
AFRICAN-PREDICT STUDY

Ashleigh Craig1, Catharina Mc Mels1,2, Dimitrios Tsikas3, Rainer H Boeger4,

Edzard Schwedhelm4,5, Aletta E Schutte1,2, Ruan Kruger1,2. 1Hypertension in Af-
rica Research Team (HART), North-West University, Potchefstroom, SOUTH AF-
RICA, 2MRC Research Unit for Hypertension and Cardiovascular Disease, North-

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.