RSD MI Vita Pramatasari Harti, Andhika Trisna Putra, Dwi Hidayah Department of Child Health, Faculty of Medicine, Sebelas Maret University/ Dr. Moewardi General Hospital Surakarta, Indonesia (Se Neonatal sepsis is a major cause of neonatal morbidity and mortality, especially in developing countries. Blood culture as the gold standard is, ‘expensive and time consuming, Therefore, various biomarkers are used for early detection of neonatal sepsis. The aim of this study was to evaluate the diagnostic efficiency of red cell distribution width (RDW) and neutrophil lymphocyte ratio (NLR) as predictors of neonatal sepsis. This is a retrospective observational study. Neonates with sepsis treated at the Neonatology Unit of Moewardi Hospital of Surakarta during October 2020-March 2021. They were selected by consecutive sampling. Analysis was performed by IBM SPSS Statistics 19 with P value <0.05 was consideredaas significant, RESULT This study included 149 neonates with neonatal sepsis who fulfilled the criteria, There were 48 neonates (32.236) with positive blood culture and 101 neonates (67.7%) with negative blood culture. Mean ROW values was 1355 in the positive culture group and 11.4 in the negative culture group. Mean NLR value was 3.07 in the positive culture group and 2.34 in the negative culture group. The ROW and NLR values between the two groups were not different significantly. ROW with cut off >4,53% has a sensitivity value of 81% and a specificity of 80%, AUC 0.424. NLR with cut off>1.595 had a sensitivity value of 64% and a specificity of 57%, AUC 0.561. The combination of ROW and NLR had @ significant correlation with positive blood culture results with P value <0.05 (r=0.27; p=0.041). In this study, ROW and NLR cannot be used as predictors of neonatal sepsis. The combination of these two parameters showed a significant correlation with positive blood culture results. Keywords: neonatal sepsis, Pete eae ea) d Table 1. Baseline characteristics ofthe subjects um mie ain ase mi spin seen Table 2. Comparison of ROW and NUR levels to blood culture results i Postivesloodcuhure BE Nogathe Table 3, Performance of biochemical markers in distinguishing between cases with postive blood culture ard cases with negative blood culture Paamettaner SBSH NOuden yc senmany Specter ROW imei) 435 O61 Om UK Boa Naiman) 3070207 0561 GRAN Siam “Mousa $0, Moustafa AN, Aly HM. Prognostic value of red celldistbution wisth, platelet parameters, and the hematological scoring systern in neonatal sepsis. Egypt Haematol, 2019;44:183-9 2. Khadijah Ricky Sumitro KR, Utomo, MT, Widedo ADW. Neutrophil-to-lymphocyte ratio as an aiternative marker lof neonatal sepsis in developing countries. Oman Med J 2021365149 3. Zhang HB, Chen J, an QF, Ma X), Zhang SY. Diagnostic valuesofredcelldistributon width latelet distribution width and neutrophillymphocyte count ratio for sepsis. Exp Ther Med, 2016;12:2215-9 Pe one)