DEPARTMENT OF PHYSIOLOGY

STUDY GUIDE
Dr. Yohannes Mengiste

SKELETAL & SMOOTH MUSCLE

CLASSIFICATION OF MUSCLES (Voluntary basis & microscopic appearance)

SKELETAL MUSCLE:
1. Physiologic anatomy of skeletal muscle
 Myofibrils
 Layers covering the muscle
2. Molecular structure
 Actin & Myosin
 Thick & thin filaments
 Troponin & tropomyosin
 Nebulin & Titin
3. Structure of a Sarcomere
4. The Sarcotubular system
 Sarcoplasmic reticulum
 T-tubules
 The triad
5. Sliding- Filament theory
 Role of ATP
 Power stroke
6. Neuromuscular Junction (NMJ)
7. Excitation-contraction coupling
8. Sources of ATP in skeletal muscle
9. Characteristics/ Properties of whole muscle
10. Length-tension relationship in skeletal muscle
11. Pathophysiology:
 Myasthenia gravis
 Duchenne muscular dystrophy
 Muscle cramps
12. Rigor Motoris

SMOOTH MUSCLE:
1. Physiologic anatomy
2. Smooth Muscle contraction
3. Characteristics/ Properties of Smooth Muscles
4. Role of calcium ions

Comparison of Skeletal and Smooth muscle Contraction