Sweden, merged with Michigan-based Upjohn in 1995, architects of the deal were excited about the new synergies they were sure to achieve through the international marriage of the two pharmaceutical companies. But in addition to substantial cost savings and other efficiencies, they realized some unanticipated headaches. The Swedes bristled at the aggressive management style of the American executives; the Americans were frustrated by the Swedish tradition of taking off July for vacation. Pharmacia and Upjohn had a classic case of culture clash, with serious consequences for the success of the merger. In fact, only 20% to 25% of mergers and acquisitions turn out to be clear winners, according to a 1997 study by El Segundo, Calif.–based Computer Sciences Corporation. Another 30% to 40% clearly fail, and the rest fall somewhere in between. Other research confirms that the majority of business combinations never produce the anticipated value, with increasing numbers ending up in the business equivalent of divorce—a break-up or spinoff. Why are there so many well-intentioned flops? The answer lies in a failure to consider the cultural consequences first by performing a cultural due diligence. “When it comes to putting two companies together, it’s relative child’s play to snap together the Lego pieces,” says Eliot Daley, director of the strategy practice at Arthur D. Little Inc. in Cambridge, Mass. “But mergers and acquisitions have to create two kinds of value. They have to create a more efficient machine and, second, they have to create greater growth potential. You can get the first result, the cost efficiency, with a slide rule. But you can’t get the growth without people working together.” Lila Booth, a Philadelphia-area consultant