Progress Report Activity

of Dengue Team

By
Prof.dr.H.Soegeng Soegijanto,Sp.A(k)DTM&H

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Indonesia-Japan
CRC-ERID

Dengue team members

Indonesia side Japan side

Prof. Soegeng Mr. Kris Prof.Dr. Konishi

Prof. Fedik Ms. Helen Dr. Yamanaka
Dr. Subagyo Mr. Eryk Prof. Dr. Kameoka
Dr. Dominicus Ms. Siti Mr kotaki
Dr .Ika
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Studies on Flavivirus diseases

1. Dengue
2. Japanese encephalitis
Virus isolation
3. West Nile
etc… Phylogenetic analysis of
Indonesian isolates

Basic study for new Epidemiology

Diagnosis/Treatment
Social activity
Diagnosis kit
Medicine Diagnosis Mosquito
Prevention
Treatment control study
Our team had two topic papers, had been
presented in International Seminar CRC-EIRD, in
Hokkaido, Japan in November 2008.
1. Complement levels control enhancing and
neutralizing activity of mouse monoclonal
antibodies against dengue virus.
2. Sample Method for evaluating dengue
vaccine effectiveness using mice.

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The other paper, had been presented in
International meeting for JE.V ecology, Asia,
2009.
 Prevalence of antibodies to Japanese
encephalitis virus among pigs in Bali and
East Java Indonesia, 2008.

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The Following papers, had been presented in
International Congress CRC-ERID in Bangkok,
2009.
1. The Changing level of GM-CSF and TNF α in
children suffered from dengue haemoragic
fever grade I & II who has received PSIDII
FOLLIUM extrac as a marker of imun
response phenomena.
2. Relationship between complement activity
and disease severity in dengue fever and DHF
patiens in Indonesia.

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 Profile of Dengue Serotype
circulating in Surabaya had been
presented in “PETRI” congress in Bali 2010
.
(Aryati, Puspa, Soegeng Soegijanto)

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SEROTYPE AND CLINICAL PERFORMANCE
OF DENGUE VIRUS INFECTION ON THE
YEAR 2009
was presented on september 30, 2010 in
ITD Airlangga University

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THE CHANGING CLINICAL PERFORMANCE OF
DENGUE VIRUS INFECTION IN THE YEAR 2009
was presented on November 11, 2010 in
Vietnam.

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Primary Isolation and Phylogenetic
Studies of Chikungunya Virus from
Surabaya,Indonesia.

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Southeast Asian Journal of Tropical Medicine and Public Health

43(1): 29-33. 2012

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 Antibody surveillance

Japanese encephalitis virus (JEV)

Swine Mosquito Human
Dead End Host
Amplifier Vector

Prevalence of JEV Ab in pig population (Java and Bali Island)

1 paper (JJID)

Dengue virus
Prevalence of antibodies showing ADE and neutralizing activities in
Philippine and Indonesian children
1 paper (Microbes and Infection)
 Indonesia-Japan-Thailand
Collaborative Study
Surabaya agreement, 23 November, 2011

Joint meeting in Bangkok, 14 May 2012

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JEV, WVN, CHIKV

1. Dengue virus surveillance

(1) Patients Ms. Siti

DENV1
(2) Mosquitoes Mr. Kris DENV2
DENV3
(3) Other islands Prof. Soegeng DENV4
Mr. Eryk
Joint Forum IN-JP-TH

2. Mosquito control Dr. Subagyo Ethical approval?

Copper fiber Start control activity
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Collaborative research among ID-JP-TH

Monoclonal and polyclonal analysis of dengue antibodies in
Indonesian and Thai populations
1. Generation of monoclonal antibodies against DENV
PBMC
(Patient) ・Screening
Fusion
・Characterization
SPYMEG
Hybridoma
Need to take care of cells everyday Ms. Siti

2. Serological survey based on new ADE assay

・Serum samples from patients and healthy people
・DENV1-4 including various genotypes
Mr. Kris
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Exchange technology
Indonesia Thailand
ADE assay MAb

MAb ADE assay

Generate MAb Establish the ADE assay in

In Indonesia Thailand
 Based on this idea on 15 -29 juli 2012
trainer from Bangkok Associate Prof Tamaki
Okabayasi and Orapim Puiprom came in
ITD.And trained groups Dengue & HIV .
The result of study got a possitive
future idea.But CRC-ERID Kobe & ITD
Airlangga University Groups want to continue
Study Epidemiology doing in Bangkalan &
Lombok Island.

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The future program of Dengue Virus Team ITD
Dx
STEAM 4a Market
Kit
CELL
Vacci 4b
Product ne
Herbal
4c
2 3

R&D

Problems
Host

Agent
Environment
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 J-GRID
Japan Initiative for Global Research Network on Infectious Diseases

Kobe University Osaka University

CID RIMD
Masanori Kameoka
Center for Infectious Diseases Research Institute for Microbial Diseases

Ministry of Public Health

Department of Medical Sciences
RCC-ERI
Research Collaboration Center on Emerging and
Re-emerging Infections
BIKEN Endowed
Mahidol University Department of Dengue
MOCID Vaccine Development
Mahidol-Osaka Center for Infectious Diseases

Airlangga University
International CRC-ERID
Collaborative Research Center for Emerging
collaboration on and Re-emerging Infectious Diseases

infectious diseases
Dengue HIV/AIDS Google Earth
Thank You

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