PREDISPOSING PRECIPITATING

FACTORS FACTORS

Children under Environmental factors Infections (viral,

Sex Ethnicity bacterial)
5 years old

External trigger (enviornment,

infection) in susceptible host
activates the immune system;
neutrophils, macrophages, IgA,
CD8 + T cells

However,antigen presenting cells will pick up

these antigens somehow misdirects the attack
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Hyperstimulated immune cell types

goes against the endothelial cells,
and collagen f ibers

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Systemic inf lammation:

Vessel wall inf lammation of
coronary arteries

Destruction of endothelial cells, Dilation of small blood vessels Cytokine release (IL- 1, TNF-?) ? production of inf lammatory cells
elastin and collagen f ibers f rominf lammatory cells spread within lymph nodes

? structural integrity in vessel edema and fever cervical

Inf iltration of lymphadenopathy
walls erythema of lymphocytes
hands and feet

MUCOSAL INVOVLEMENT DERMAL INVOLVEMENT

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weakened wall results in

ballooning of coronary
arteries conj unctivitis,
cracked red lips, generalized skin
strawberry tongue rash

coronary arteritis