Autosomal inheritance

We have 22 Autosomes in both male and female body.

Autosomes inheritance pattern.

Now there’s a letter in here that represents autosomal disease and the small letter a represents the
active disease. Now if there are two alleles are recessive only the disease will trigger. Now imagine
small letter a is a faulty gene and capital letter A is a heterozygous form, as long as the heterozygous
form is present the disease will not show.

AA – this offspring will not get any disease because they both have good copy

Aa – this copy has one good and bad but the good copy is dominance so it will not have the disease

aa – This copy will have the disease because they have both two faulty copies.

Sex Linked inheritance or X linked inheritance

The disease will only trigger if two copies has faulty alleles.

Now for example your mother has a color blindness disease

Xc x x x y

Xc x – the chances of getting female a disease is less because female needs two copy of color blind
chain. The X will compensate the color blind sickness. But this person will still be a carrier of the disease
even though they didn’t show the disease or have it.

Xc Y – this one will get a color blind because the Y gene will not compensate the color blindness. Males
are much likely to get the disease.

Now the difference of the autosomal inheritance and sex linked inheritance, autosomal inheritance isn’t
gender base it don’t choose who will have the disease while the x linked inheritance male most likely get
the disease.

Chromosomal Disorder

One of example of chromosomal disorder is the turners syndrome. Turners syndrome include No
menstruation, no breast development, narrow hips, broad shoulders and neck and they have 96-98%
do not survive to birth. Usually happened in girl. It only consist of single X chromosome that’s why it’s
called Monosomy nondisjunction. This syndrome only has 45 chromosomes.

Multifactorial Inheritance

This disease triggers because of the multiple genes and environmental factor. Because there are
multiple contributing factors there is no genetic test currently available for diagnosis. Although it can
cluster in families they don’t have a clear cut pattern of inheritance. Now if the first child has a
multifactorial inheritance disease the second child has greater chance also to get the disease.