CED a CERTIFICATE OF ANALYSIS Rie HR AG No.:COA-S170305002-01 [Product Name Solesbu Code ae PahBEs | ema fe = ts. he. YAKBu-EM201703201 ee xing 2017.03.04 Test No. Tesi Metnod TWEYAKE 00 bee Prone iii, ‘SPC-YAKB 00 Bee Date | naizo19.02.28 a 119.80kg Packing Size 7TE.G0kg/package rodueed by ‘Synthesis Plant IT | eae. fe PsbeMs eri = I) ‘Test lems ‘Acceplanca Criteria Resulis Conglusion Pr RS ‘ae eae ‘Appearance White or off.white powder. Wile paver Conforms teak EL. OR3 FT Bik Bx owe “The TR spectrum of the sample | The IR spectrum of the sample le ix | Should be concordant with hat of | concordant with that of the | Conforms the Reference Standard. ‘Standard, SE 254 Be sXe ALi He || Thetetenton time of the major [Te retenion tne of the major Identification peak in the Test Solution should | peak in the Test Solution is Hi be concordant with that in the | concordant with that in the Hetc | Standard Solution as obtained in | Standard Solution as obtained in | Conforms Assay. Assay. eRe ARNT, GMI | em, GR Hy SR ATG LICE AGRA | RAT. a A EA dB siete. Claiity of Solution Solution should be clear Clear Conforms eG Aaa Bt bg erie Water 0.5% 0.05% Conforms. ASP : : awe Tpurity A ane Not detected Conforms A Ft th Heme Img 8 Conforms: on 50.10% <0.05% coum Tmpuriy & Not detected Conforms "HG ont et Feu ee 30.10% Not detected Conforms: Related substances meg we ees AROK Tine 50.10% I a athe impurity jat detected forms Ene Ss et Hawe Unspectied : Not detected Conforms Impurities 50.10% ae eae Total impurities Conforms iy ss S1.0% 0.05% HOME 98. 0%-102.0% fom {on the ani basis) 100.2% oo iba! oan tao (Heat bai mw ‘Optical Rotation conforms eee +37,0°441,0° +387" aawe ‘Ada. Xiaba Development Zone, RuyuanGounty, Shaoguan City, Guangdong hk: RAMAN AMAR LARA RAAMM PSIERE, Me, 542721 (+86)0751 5286508, Faxc(+86)0751-5296521 Dec.No./SCFFS : AN-SPC-YAKBA Ver. NaH : 00 Page 1 of vinee,$12721, ChinaResidual Solvents aR ee $1000ppm Elemental impurities. THRABA Crystal form* ate + ‘There should be characteristic peaks | BH CAS): $1.5ppm (Cd): = 0.5ppm 3% (Hg): $ 3.0ppm [___® ePby S0.8ppm #8 (Co): $5,0ppm L 4 (ND: <20ppm 8 CV): 10pm #8 (Sn); <600ppm #8 (Mg). $1000ppm at6.0420.2", 8.1320.2°, 10.3320.2°, 12.6520.2", 20.09%0.2", 20.7720.2°, and The XRD spectrum of the sample correspand to that of crystal form VI. HORA HE 6.0420.2°, 8.1320.2°, 10.3340.2", 12.6810.2", 20.0940.2", 20.7740.2°sb ERE, 15 VIE XRD fit — Thare are characteristic peaks at 6.11", 8.22%, 10.40", 12.73", 20.16°, 20.83", and The XRD spectrum of the ‘sample correspond to that of crystal form VI. ‘PRREMTE 6.11", 8.22", 10.40°, 12.73", 20.16", 20.837 SHEN, 5a, XRD Hg ‘Conforms Ae ie ‘Add.: Xiaba Development Zono,R luyuanCounty, Shaeguan City, Guangdong Provines,512721, China SAR A AL HAAR AA FS Tol.(+86)0751-8208508; Fax-(*86)0751-52868: sis 812724 24 Doc.No/t hit: AN-SPC-YAKBA Ver, Nouba : 00 Page 2 of 3ED No.:COA-S170305002-01 Batch No, Bess YAK Test ema Conclusion Le] Sms it Dio: 1.84um Pso Intormatively = ne Oe a Buk density Informatively = er sien — Tapped density Informat Ai A ae cat TAMG Orch me — Microbiological Sanam = Examination, $10?cfulg = - SE ME Be EMA Ae Escherichia coli (ig) - ASAE MA 19 KE Agta = Note: lanes thatthe testitem may not be conducied on every batch, bu oniy onthe Tat ree batches in every year. “signify outsourced test Ste: PAWEL, teh he Tate. fir ossFete OH Conclusion: The results of the above items meet the in-house specification Reported by/Date IE AVA: fhiret Reviewed by/Date ERNE ME: Hat Soy ‘Approved by/Date ‘mE AVE: aee"L ‘Add: Xiaba Development Zone,RuyuanCounty, Shaoguan City, Guangdong Province,512721, China AARNE Saks RA ERT Re HA FRA, Wel, $12724 Tel.:(+86)0751-5286508, Fax:(+86)0751-5286521 Doc.No./ 4H: AN-SPC-YAKBA Ver. NoJICE : 00 Page 3 0f3