Product Information

S5003 FK-506
Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 804.02 C44H69NO12 DMSO 99% at -20 2 years 104987-11-3
O H N O O O O OH O OH

Novel Life Science Reagents

for Cell Signaling Research

Toll Free:
(877)796-6397
-- USA and Canada only --

Fax:
+1-713-796-9816

Orders
+1-713-922-4115
OH O

enquiry@selleckchem.com

Tech Support
tech@selleckchem.com

Synonyms: Tacrolimus,

Prograf, FK506

(chemistry support)

techbio@selleckchem.com
(bio support)

Biological Activity
FK-506 inhibits Ca2+-dependent transcription of lymphokine genes in T cells. FK-506 (0.1 to 300 nM) concentration dependently inhibited histamine release from lung parenchymal mast cells activated by anti-IgE. FK-506 was more potent in lung mast cells than in basophils (IC50 = 1.13 +/- 0.46 nM vs 5.28 +/- 0.88 nM; p less than 0.001), whereas the maximal inhibitory effect was higher in basophils than in lung mast cells (88.4 +/- 2.5% vs 76.4 +/- 3.8%; p less than 0.01).[2] FK-506 (1 to 300 nM) concentration dependently inhibited histamine release from basophils activated by Der p I Ag, anti-IgE, or compound A23187. FK-506 was more potent than CsA when basophils were challenged with Ag (IC50 = 25.5 +/- 9.5 vs 834.3 +/- 79.8 nM; p less than 0.001), anti-IgE (IC50 = 9.4 +/- 1.7 vs 441.3 +/- 106.7 nM; p less than 0.001), and A23187 (IC50 = 4.1 +/- 0.9 vs 36.7 +/- 3.8 nM; p less than 0.001). The maximal inhibitory effect of FK-506 was higher than that caused by CsA when basophils were activated by Der p I (80.0 +/- 3.6 vs 49.5 +/- 4.7%; p less than 0.001) and anti-IgE (90.4 +/- 1.8 vs 62.3 +/- 2.9%; p less than 0.001).

Web
www.selleckchem.com

Selleck Overnight Delivery Service

Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

References
[1] A de Paulis et al. The Journal of Immunology. 1991 Dec 15;147(12):4278-4285 [2] A de Paulis et al.J Immunol.1991; 146: 2374-2381

Goods ordered in error can only be accepted

MSDS & CoA

Please visit www.selleckchem.com to download MSDS and CoA.

for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

Copyright 2010 Selleck